Mechanisms of Yersinia YopO kinase substrate specificity by Lee, Wei Lin, Singaravelu, Pavithra, Wee, Sheena, Xue, Bo, Ang, Khay Chun, Gunaratne, Jayantha, Grimes, Jonathan M., Swaminathan, Kunchithapadam, Robinson, Robert C.

“…Using artificial substrates we clarified YopO’s substrate length requirements and its phosphorylation consensus sequence. These findings provide fresh insight into the mechanism of the YopO kinase and demonstrate that YopO executes a specific strategy targeting actin-modulating proteins, across multiple functionalities, to compete for control of their native phospho-signaling, thus hampering the cytoskeletal processes required for macrophage phagocytosis.…”
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Identification and characterization of roseltide, a knottin-type neutrophil elastase inhibitor derived from hibiscus sabdariffa by Nguyen, Giang Kien Truc, Tam, James Pingkwan, Loo, Shining, Kam, Antony, Xiao, Tianshu, Liu, Chuan Fa

“…Taken together, our findings demonstrate that roseltide rT1 is a novel knottin-type neutrophil elastase inhibitor with therapeutic potential for neutrophil elastase associated diseases.…”
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Neurobiology of culturally common maternal responses to infant cry by Rigo, Paola, Bornstein, Marc H., Putnick, Diane L., Esposito, Gianluca, Swain, James E., Suwalsky, Joan T. D., Su, Xueyun, Du, Xiaoxia, Zhang, Kaihua, Cote, Linda R., De Pisapia, Nicola, Venuti, Paola

“…Culturally common responses to own infant cry coupled with corresponding fMRI findings to own infant and to generic infant cries identified specific, common, and automatic caregiving reactions in mothers to infant vocal expressions of distress and point to their putative neurobiological bases. …”
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A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator by Ghim, Mean, Pang, Kuin T., Arshad, Mehwish, Wang, Xiaomeng, Weinberg, Peter D.

“…Hence the new methods revealed an important property that would not have been observed without growth segmentation, suggesting that they could find more widespread application.…”
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Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework by Pal, Mintu, Chen, Huizhi, Lee, Bae Hoon, Lee, Justin Yin Hao, Yip, Yun Sheng, Tan, Nguan Soon, Tan, Lay Poh

“…In this study, we focused on two major points (i) designing and fabrication of 3D hybrid scaffolds comprising electrospun fibers with cancer cells embedded within hydrogels, and (ii) determining the potential roles of 3D hybrid scaffolds associated with EMT in cancer progression and metastasis. Our findings revealed that 3D hybrid scaffold enhances cell proliferation and induces cancer cells to undergo EMT, as demonstrated by significant up-regulation of EMT associated transcriptional factors including Snail1, Zeb1, and Twist2; and mesenchymal markers whereas epithelial marker, E-Cadherin was downregulated. …”
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Modeling the change of beach profile under tsunami waves : a comparison of selected sediment transport models by Li, Linlin, Huang, Zhenhua

“…For real tsunamis, high suspended sediment concentration may occur, and density stratification and hindered settling effect play an important role; therefore, Delft3D, with both hindered settling and density stratification being considered, may perform better than XBeach. The findings reported here will be useful for researchers and practitioners working on tsunami hazard mitigation.…”
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A prospective observational study comparing rates of medical instability between adolescents with typical and atypical anorexia nervosa by Brennan, Cliona, Cini, Erica, Illingworth, Sarah, Chapman, Simon, Simic, Mima, Nicholls, Dasha, Chapman, Victoria, Simms, Conor, Hayes, Ellen, Fuller, Sarah, Orpwood, Jade, Tweedy, Nicola, Baksh, Tahmida, Astaire, Emma, Bhakta, Dee, Saglio, Eloise, Stevenson, Annie, Buchbinder, Melissa

“…A significant regression equation was found for percentage median body mass index, but not rate of weight loss, as a predictor of blood pressure, serum phosphorous and magnesium. Conclusions: Our findings indicate that medical instability occurs across a range of body weights in young people with AN and AAN. …”
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Oral and topical administration of a geranyl acetophenone attenuates DNCB-induced atopic dermatitis-like skin lesions in BALB/c mice by Mohd Kasim, Vivi Nur Khalieda, Lee, Yu Zhao, Bakrin, Ikmal Hisyam, Hussain, Mohd Khairi, Israf, Daud Ahmad, Shaari, Khozirah, Tan, Ji Wei, Lee, Ming Tatt, Tham, Chau Ling

“…There was a minor discrepancy between the two routes of administration, with orally treated tHGA showing significant reductions in Scoring of Atopic Dermatitis (SCORAD), tissue eosinophil infiltration, serum IgE and skin IL-4 levels with treatment of 40 and 80 mg/kg tHGA, whereas topically applied tHGA showed significant reductions in all dosages. These findings suggest that tHGA exhibited therapeutic potential for AD as both oral and topical treatment ameliorates AD-like symptoms in the murine model. © The Author(s) 2024.…”
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Computational Fluid Dynamics (CFD) Validation and Investigation the Effect of Piston Bowl Geometries Performance on Port Fuel InjectionHomogeneous Charge Compression Ignition (PFI-... by Nik Ab Rashid, Nik Muhammad Hafiz, Hairuddin, Abdul Aziz, Md Rezali, Khairil Anas, Masuri, Siti Ujila, Abdulabbas Mossa, Al Anbagi Muntasser, Jaafar, Jamiluddin, Fitriyana, Deni Fajar

“…The piston bowl design employed in a Port Fuel Injection engine application exhibited different combustion phases while demonstrating similarity in attaining in-cylinder pressure. The findings for swirl induce piston bowl design indicate an enhancement of in-cylinder pressure for the Spiral Crown geometry model, reaching 9.42 MPa. …”
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Green roof thermal performance of small-scale prototype using IES-VE simulation in tropical climatic condition by Md Yacob, Mohamad Norfekry, Kasmin, Hartini, Siti Nazahiyah Rahmat, Siti Nazahiyah Rahmat, Tukimat, Nurul Nadrah Aqilah, Ahmad Nazri, Mohd Ariff

“…Simulation using IES-VE approved that green roofs can potentially reduce indoor temperatures, demonstrating their suitability for tropical regions. These findings have significant implications for sustainable building design and urban planning in hot and humid climates.…”
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A DEVELOPER'S GUIDE TO BUILDING RESILIENT CLOUD APPLICATIONS WITH AZURE : Deploy applications on serverless and event-driven architecture using a cloud database / by Trabelsi, Hamida Rebai 656262

“…Professionals looking to enhance their cloud and cloud-native programming concepts on Azure will also find this book useful. A solid background in C#, ASP.NET Core, and any recent version of Visual Studio and basic knowledge of cloud computing, Microsoft Azure, and databases will be helpful when using this book.…”
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Cognitive dynamic airspace management by Wong, Cheryl Sze Yin

“… • Static state: The formulation of finding sector shapes have been mostly proposed in a single objective optimisation framework. …”
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Green synthesis and photocatalytic insights: A review of zinc oxide nanoparticles in wastewater treatment by Hussain, Rabia Tasaduq, Hossain, Md Sanower, Jun Haslinda, Shariffuddin

“…This review summarized current scientific findings based on both unmodified and modified ZnONPs, primarily synthesized using plant sources as reducing and capping agents. …”
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Decarbonizing airport using solar and wind farm: A case of Biratnagar, Nepal by Yadav, Bharosh Kumar, Yadav, Ramhit, Jahangiri, Mehdi, Priya, S. Shanmuga, Bajracharya, Tri Ratna, Sudhakar, Kumarasamy

“…The combined 15 kW wind turbine-grid scenario is superior to the grid scenario for wind speeds of more than nine m/s and interest rates of less than 10 %. These findings increase airport authorities' and stakeholders' confidence in the investment in greener airports.…”
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Superhydrophobic surface of Ti6Al4V using direct nanosecond laser texturing by Mohd Harizan, Zul, Mahadzir, Ishak, Aiman, Mohd Halil, Ramdziah, Md Nasir, Moinuddin, Mohammed Quazi

“…Laser texturing techniques successfully improved surface roughness and profile, facilitating the development of superhydrophobic surfaces. These findings offer valuable insights for advancing surface engineering, with potential applications in the aerospace, automotive, and biomedical industries.…”
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Financial technology readiness for Shariah-compliant banking services: Post-merger perspectives by Kurniawati, Desi Tri, Fernando, Yudi, M. Abdi Dzil, Ikhram W., Masyhuri, .

“…The data were then analysed using PLS-SEM with SmartPLS software. Findings: Perceived organisational support became crucial in improving readiness to adopt the digitalisation initiative and adhere to Shariah norms. …”
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Thermal and flow characteristics of alumina nanofluids in microfluidic systems: A low-concentration study by Samylingam, Lingenthiran, Aslfattahi, Navid, Kadirgama, Kumaran, Ramasamy, Devarajan, Kok, Chee Kuang, Norazlianie, Sazali, Wan Sharuzi, Wan Harun, Nor Atiqah, Zolpakar, Mohd Fairusham, Ghazali

“…The study concludes that low-concentration Al₂O₃ nanofluids can enhance thermal performance in microfluidic systems without significantly affecting flow characteristics, making them suitable for applications requiring efficient heat dissipation, such as electronic cooling and chemical reactions. These findings provide a foundation for future research into higher nanoparticle concentrations and different base fluids, aimed at optimizing the thermal and flow properties of nanofluids in microfluidic environments. …”
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Intention to engage in inter-contractor cooperation: A belief elicitation study in the construction industry by Moshood, Taofeeq D., Ling, Yee Voon, Chai, Changsaar, Lee, Chia Kuang

“…Partial Least Square analysis assessed the factors influencing the intention to form partnering. Findings: The results supported six hypotheses, while six others were unsupported. …”
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Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora by Nurul Aina Suzlin, Sulaiman, Muhammad Farhan Syakir, Nor Azman, Mohd Fadhlizil Fasihi, Mohd Aluwi, Zainul Amiruddin, Zakaria, Mohammad Jemain, Mohammad Ridhwana, Fatimah, Salim

“…Although the high concentrations required for effective enzyme inhibition may limit the practical application of these compounds as antidiabetic therapies, this study provides valuable insights into the chemistry underlying the plant’s previously reported antidiabetic potential, particularly in a stereospecific context. The findings further support the unique biological activities attributed to the diastereomeric alkaloids, highlighting their importance in understanding the plant’s therapeutic potential.…”
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Water surge risk mapping using GIS-based spatial multi-criteria decision analysis approach by Syarifuddin, Misbari, Siti Sarah, Abd Razak, Muhammad Fuad Fahmi, Jaafar, Nadiatul Adilah, Ahmad Abdul Ghani, Mohd Faizal, Jamlos

“…A water surge risk map is developed by not only visualizing water surge factors but also weighting each relevant contributing factor, such as terrain elevation, land use type, and rainfall. The finding of the study suggests that Sg. Pandan Waterfall area falls into medium-risk water surge zones due to combination of three main factors including terrain elevation, land use or rainfall pattern. …”
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