Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…</p> <br> <p><strong>Discussion:</strong> These findings indicate an epitope-specific pathophysiology of LGI1 autoantibodies. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Main Findings</strong></p> <p>Human Capital Transfer Between Spouses: Within marital relationships, a transfer of human capital exists. …”

Guaranteed bounds on posterior distributions of discrete probabilistic programs with loops by Zaiser, F, Murawski, AS, Ong, C-HL

“…By contrast, we aim to find guaranteed bounds, which sandwich the true distribution. …”

Characterisation of collagen type I/ type II composite scaffolds for osteochondral tissue engineering by Tamaddon, M

“…The addition of chondroitin sulphate and fibrillogenesis increased the rigidity of the collagen chains and the viscosity of suspensions, thereby affecting the pore structure of the final scaffolds. A very important finding was that stem cells produced mostly collagen type II matrix molecules on these scaffolds, which differed from the production of collagen type I on type I scaffolds.…”

Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis by Donkor, ES, Osman, A, Aglomasa, BC, Awere-Duodu, A, Odoom, A, Opoku-Asare, B, Lazarus, G

“…Conclusion: This review identified gaps in knowledge and highlighted areas where prompt actions are required, it further guides future research endeavors and policy development. The findings underscore the need for further implementation of AMS programs across the West African region to enhance understanding of antibiotic use patterns, prescribing practices, and the factors influencing them in the region.…”

Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial by Yoshinaga, N, Thew, G, Hayashi, Y, Tanoue, H, Nakai, M, Clark, DM

“…An internet-delivered version of this treatment protocol (iCT-SAD) has recently been developed in the UK as a way to overcome this challenge, demonstrating comparable outcomes to face-to-face CT-SAD whilst requiring less therapist time per client. Initial findings also suggest its cross-cultural transferability, but the previous studies in other cultural settings used the English language programme and only included English-fluent participants as a second language. …”

Data for the ‘Orchid Observers’ project by Shuttleworth, S, O’Donnell, J, Lintott, C, Tweddle, J

“…The Natural History Museum (NHM) wants to find out if this is true for other wild orchids and whether all species are responding in the same way. …”

Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…I carried out validation and mechanistic studies that confirmed that loss of TMED2 and TMED10 results in nuclear FoxO1-Clover retention following insulin treatment, as well as aberrant AKT phosphorylation. These findings confirmed that TMED2 and TMED10 are novel regulators of hepatic insulin signalling.…”

The molecular determinants of Polycomb-mediated gene repression by Fursova, N

“…In conclusion, through systematic dissection of the Polycomb system, I have provided compelling evidence for a variant PRC1-dependent logic for formation of Polycomb chromatin domains and repression of Polycomb target genes. Together, my findings place PRC1 and its catalytic activity at the forefront of Polycomb-mediated transcriptional silencing, paving the way for a mechanistic understanding of Polycomb system function.…”

Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…</p> <p>My studies and thesis underscore the potential of NTX as a viable alternative for bacterial infection prevention/treatment in poultry farming. The findings contribute to the development and prudent use of NTX in farm animal production, offering a promising solution to the challenge of AMR in agriculture.…”

Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Amboko, B, Nzinga, J, Tsofa, B, Mugo, P, Musiega, A, Maritim, B, Wong, E, Mazzilli, C, Ng’ang’a, W, Hagedorn, B, Turner, G, Musuva, A, Murira, F, Ravishankar, N, Hussein, S, Barasa, E

“…The two strands will be mixed during data collection to refine questions, with findings triangulated during analysis and interpretation to provide a comprehensive understanding of PCN implementation. …”

Investigating the functional and metabolic role of carnitine in the diabetic heart using hyperpolarized MRI by Savic, D

“…</p> <p>Different diabetic models were initially investigated to find the most appropriate model in which to modulate L-carnitine levels. …”

Mechanistic insights on protein aggregation and phase separation by Casablancas Antràs, V

“…The primary aggregation of tau R3 includes dimerisation and the formation of a tetrameric nucleus that elongates into fibrils, which can fragment. We find that D-TLKIVW, originally developed as an elongation blocker, has a more nuanced mode of action than expected and targets in particular the nucleus.…”

Childlessness and its associated factors among Chinese women: a nationwide population-based study by Han, Q, Dang, J, Wu, Y, Ye, W

“…Conclusions: This study used the most recent nationwide survey data from China to identify factors associated with childlessness and reproductive anxiety, with an emphasis on socio-economic factors and domestic violence. The findings highlight the significant impact of domestic violence on fertility behaviors and reproductive anxiety, providing valuable evidence for future policy interventions.…”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…We classified pairs of conditions as across or within-domain based on the international classification of disease.</p> <p><strong>Findings: </strong>We identified 72 chronic conditions, with 43.6% of 2546 pairs showing higher co-occurrence than chance in primary care and evidence of shared genetics. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…</p> <p>This research includes the findings from an exploratory study to scope the novelty of focusing on journalists as a specific population threatened by the IoT. …”

Programs to Address Violence for Military Families: a Systematic Review by Dodge, J, Wortham, W, Kale, C, Williamson, V, Ross, A, Maher, S, Kononowech, J, Winters, J, Sullivan, K

“…Conclusion: This study had three main findings: (1) The majority of interventions were for Veterans and/or their partners rather than active service personnel; (2) All interventions reported positive outcomes in the reduction of self-reported IPV, with the majority of these outcomes maintained over time; (3) While we intended to assess military family-level interventions that targeted IPV and CM, we only found three studies that targeted or included CM. …”

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…</p> <p>We first develop a simple ordinary differential equation model of tumour growth which distinguishes between nutrient and space limited growth control. We find that there are three distinct growth regimes: nutrient limited, space limited and bistable, where both mechanisms of growth arrest coexist. …”

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I by Liu, X, Zhang, Z, Aguirre, T, Shipton, ML, Fu, L, Du, J, Furkert, D, Qi, J, Chin, AC, Riley, AM, Liu, T, Zhang, X, Potter, BVL, Fiedler, D, Zhu, Y, Fu, C

“…</p> <p><strong>Conclusions:&nbsp;</strong>Our findings reveal a mechanism by which blocking IP6K1 boosts apoA-I production. …”

Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts by Wood, GK, Babar, R, Ellul, MA, Thomas, RH, Van Den Tooren, H, Easton, A, Tharmaratnam, K, Burnside, G, Alam, AM, Castell, H, Boardman, S, Collie, C, Facer, B, Dunai, C, Defres, S, Granerod, J, Brown, DWG, Vincent, A, Marson, AG, Irani, SR, Solomon, T, Michael, BD

“…<p><strong> Conclusion </strong></p>Age, GCS, fever and aetiology can effectively stratify acute seizure risk in patients with encephalitis. These findings can support the development of targeted interventions and aid clinical trial design for antiseizure medication prophylaxis.…”