Frailty trajectories preceding dementia in the US and UK by Ward, DD, Flint, JP, Littlejohns, TJ, Foote, IF, Canevelli, M, Wallace, LMK, Gordon, EH, Llewellyn, DJ, Ranson, JM, Hubbard, RE, Rockwood, K, Stolz, E

“…</p> <p><strong>Conclusions and Relevance: </strong>These findings suggest that frailty measurements may be used to identify high-risk population groups for preferential enrolment into clinical trials for dementia prevention and treatment. …”

The epidemiology of periportal fibrosis and relevance of current Schistosoma mansoni infection within the context of repeated mass drug administration: a population-based, cross-se... by Ajayi, S, Nabatte, B, Mpooya, S, Tinkitina, B, Opio, CK, Kabatereine, NB, Chami, G

“…</p> <br> <p><strong>Findings:</strong> Between Jan 6 and Feb 3, 2022, 342 (12·1%) of 2834 participants were diagnosed with periportal fibrosis. …”

Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

“…Evidence was of variable quality, given the heterogenous findings, asymmetry in the funnel plots, and the diverse AMSTAR 2 ratings, prediction intervals and excess significance ratios. …”

The role of p53 and ASPP2 in neurodegenerative disease by Turnquist, C

“…</p> <p>Here I examine the molecular basis for loss of cell polarity and accelerated cell death mediated by apoptosis stimulating protein of p53 2 (ASPP2) in neurodegeneration. In this study we find that ASPP2 mediates STAT1Linduced apoptosis. …”

Accuracy and safety of an autonomous artificial intelligence clinical assistant conducting telemedicine follow-up assessment for cataract surgery by Meinert, E, Milne-Ives, M, Lim, E, Higham, A, Boege, S, de Pennington, N, Bajre, M, Mole, G, Normando, E, Xue, K

“…This study is registered with&nbsp;ClinicalTrials.gov&nbsp;(NCT05213390) and ISRCTN (16038063).</p> <p><strong>Findings:&nbsp;</strong>202 patients were included in the analysis, with data collection completed on 23 March 2022. …”

An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England by Nafilyan, V, Humberstone, B, Mehta, N, Diamond, I, Coupland, C, Lorenzi, L, Pawelek, P, Schofield, R, Morgan, J, Brown, P, Lyons, R, Sheikh, A, Hippisley-Cox, J

“…Using predicted 90-day risk of COVID-19 death, we calculated r2 values, Brier scores, and measures of discrimination and calibration with corresponding 95% CIs over the two time periods. <p><strong>Findings</strong></p> We included 34 897 648 adults aged 19–100 years resident in England. 26 985 (0·08%) COVID-19 deaths occurred during the first period and 13 177 (0·04%) during the second. …”

An epigenetic analysis of planarian stem cells by Dattani, A

“…Bivalent histone modifications in mammalian embryonic and germline stem cells enable transcriptional poising of genes, and consistent with this we find that bivalent genes in planarian NBs are marked by paused RNA Pol II at the promoter-proximal region. …”

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study by Hamill, V, Wong, S, Benselin, J, Krajden, M, Hayes, PC, Mutimer, D, Yu, A, Dillon, JF, Gelson, W, Velásquez García, HA, Yeung, A, Johnson, P, Barclay, ST, Alvarez, M, Toyoda, H, Agarwal, K, Fraser, A, Bartlett, S, Aldersley, M, Bathgate, A, Binka, M, Richardson, P, Morling, JR, Ryder, SD, Barnes, E

“…Drug and liver related causes of death were the main drivers of excess mortality. These findings highlight the need for continued support and follow-up after successful treatment for hepatitis C to maximise the impact of direct acting antivirals.…”

Enhanced rice (Oryza sativa L.) plant growth and nutrient contents during the vegetative stage through zinc solubilizing bacterial bead inoculation by Irsyad Sulaimi Ramly, Nur Maizatul Idayu Othman, Aida Soraya Shamsuddin, Tan, Ali Kee Zuan, Nor Hafizah Zakaria, Fadzilah Adibah Abdul Majid, Nur’ Amira Hamid

“…Mixed inoculant also improved soil fertility by increasing the available Zn (6.17 mg kg-1) in the soil, however, it lowered the soil pH to pH 5.8. These findings highlight the potential of ZSB, particularly A. nosocomialis (SR R-10), to improve rice plant’s growth and nutritional quality and increase the bioavailability of zinc in the soil to promote sustainable agricultural practices.…”
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A comprehensive study of laser irradiated hydrothermally synthesized 2D layered heterostructure V2O5(1−x)MoS2(x) (X = 1–5%) nanocomposites for photocatalytic application by Jameel, Muhammad Hasnain, Yasin, Aqeela, Samia, Mayzan, Mohd Zul Hilmi, Roslan, Muhammad Sufi, Esa, Fahmiruddin, Agam, Mohd Arif, Mohd Zaid, Mohd Hafiz, Althubeiti, Khaled, Aljohani, Mohammed

“…Furthermore, dielectric findings like the complex dielectric function, tangent loss, electrical conductivity, quality factors, and impedance of V2O5(1−x)MoS2(x) (X = 1–5% w/w) nanocomposites are studied. …”
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Effects of multilingualism on brain structure, cognition and language processing by Yee, Jia’en

“…This is despite multilingualism being a common phenomenon in many parts of the world. Findings from past bilingual studies have shown patterns of volumetric expansions that are followed with reductions as language experience increases; possibly signifying renormalisation. …”
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Infection patterns of scabies and tinea between inland and resettled indigenous Negrito communities in peninsular Malaysia by Er, Yi Xian, Than, Leslie Thian Lung, Muslim, Azdayanti, Yap, Nan Jiun, Tee, Mian Zi, Abdull-Majid, Nurmanisha, Lee, Soo Ching, Shahrizal, Shezryna, Lim, Yvonne Ai Lian

“…Risk analysis revealed specific associations: scabies with Kensiu subtribe (P = 0.002), high income (P = 0.001) and underweight individuals (P = 0.009); tinea versicolor with Bateq subtribe (P = 0.003), resettled villagers (P < 0.001), males (P = 0.040), and overweight/obese individuals (P = 0.015); and tinea imbricata with Bateq (P = 0.011) and smokers (P = 0.004). These findings highlight a complex interplay between environment and lifestyle in skin infection prevalence. …”
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Enhanced rice (Oryza sativa L.) plant growth and nutrient contents during the vegetative stage through zinc solubilizing bacterial bead inoculation by Ramly, Irsyad Sulaimi, Othman, Nur Maizatul Idayu, Shamsuddin, Aida Soraya, Zuan, Ali Tan Kee, Zakaria, Nor Hafizah, Abdul Majid, Fadzilah Adibah, Hamid, Nur’ Amira

“…Mixed inoculant also improved soil fertility by increasing the available Zn (6.17 mg kg-1) in the soil, however, it lowered the soil pH to pH 5.8. These findings highlight the potential of ZSB, particularly A. nosocomialis (SR R-10), to improve rice plant’s growth and nutritional quality and increase the bioavailability of zinc in the soil to promote sustainable agricultural practices.…”
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Development of an integrated scheduling model for handling equipment in automated port container terminals by Sadeghian, Syed Hamidreza

“…In addition, results proved that the modified meta-heuristic algorithm is able to find near optimal solutions and on average, the solutions found by the GA algorithm are only 0.2% worse than the optimal solutions and in the worst case in the test cases this difference is 2.3% which is acceptable. …”
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Tea leaf [Camellia sinensis (L.) Kuntze] extract-synthesized silver nanoparticles as antimicrobial agent against foodborne pathogens by Loo, Yuet Ying

“…This is the first report to demonstratethat the application of AgNPs in washing-up liquid has significant antibacterial activity against foodborne pathogens. Overall, the findings show that AgNPs have strong antibacterial activity and can be an alternative antimicrobial agent.…”
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Development of superhydrophobic ceramic membrane decorated with flake-like structure by two-step synthesis for seawater desalination by membrane distillation by Omar, Najib Meftah Almukhtar, Othman, Mohd. Hafiz Dzarfan, Tai, Zhong Sheng, Puteh, Mohd. Hafiz, Wong, Keng Yinn, Tan, Huiyi, Tonni Agustiono Kurniawan, Tonni Agustiono Kurniawan, Ooi, Boon Seng, Nomura, Mikihiro, Iwamoto, Yuji

“…A seawater desalination experiment by a membrane distillation (MD) system evaluated the performance of MK-SS HFM for 500 min. Significant findings: The results revealed that the MK-SS/4 h HFM, characterized by its flake-like structure, exhibited optimal superhydrophobic behavior. …”

Machine learning, IoT and 5G technologies for breast cancer studies: A review by Saroğlu, Havva Elif, Shayea, Ibraheem, Saoud, Bilal, Azmi, Marwan Hadri, El-Saleh, Ayman A., Saad, Sawsan Ali, Mohammad Alnakhli, Mohammad Alnakhli

“…The present study aims to examine various classifiers utilized in ML and DL methodologies for the purpose of diagnosing BC. Research findings have demonstrated that DL has superior performance compared to standard ML methods in the context of BC diagnosis, particularly when the dataset is extensive. …”
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Towards the Realization of National Automotive Policy (NAP): Modelling the Malaysian Consumers’ Purchase Behavioral Intention towards Energy Efficient Vehicles (EEVs) (S/O 14165) by Mohd Noor, Nor Azila, Mohd Fadhil, Faudziah Hanim, Md Isa, Filzah, Salleh, Hayatul Safrah, Muhammad, Azli

“…Consumers’ attitudes mediate the relationships between functional value, emotional value and novelty value and consumers’ behavioural intention to purchase energy efficient vehicle. The findings of this study show that brand preference does not perform any moderating role on the relationship between consumers’ attitudes and purchase behavioural intention, which means that brand preference has no influence on association between consumers’ attitudes and purchase behavioural intention. …”
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Agarwood oil grade clustering of aquilaria malaccensis species using Extraction by GC-MS analysis: Efficient KNN algorithm based on patterns visualization of two-dimensional graph by Siti Mariatul Hazwa, Mohd Huzir, Anis Hazirah ‘Izzati H., Al-Hadi, Amir Hussairi, Zaidi, Nurlaila F., Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The agarwood oil sample data were categorized into low, medium-low, medium-high and high grades. The findings show that KNN yielded 100% accuracy. Then, 2D graph was applied to plot the sample visualization pattern parallel with KNN accuracy. …”
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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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