Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy by Peng, Boya, Nguyen, Trinh Mai, Jayasinghe, Migara Kavishka, Gao, Chang, Pham, Thach Tuan, Vu, Luyen Tien, Yeo, Eric Yew Meng, Yap, Gracemary, Wang, Lingzhi, Goh, Boon Cher, Tam, Wai Leong, Luo, Dahai, Le, Minh TN

“…We evaluate the anti-cancer activity of two novel RIG-I agonists, the immunomodulatory RNA (immRNA) with a unique secondary structure for efficient RIG-I activation, and a 5' triphosphorylated antisense oligonucleotide with dual function of RIG-I activation and miR-125b inhibition (3p-125b-ASO). We find that RBCEV-delivered immRNA and 3p-125b-ASO trigger the RIG-I pathway, and induce cell death in both mouse and human breast cancer cells. …”
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Food environments and obesity: a geospatial analysis of the South Asia Biobank, income and sex inequalities by Atanasova, Petya, Kusuma, Dian, Pineda, Elisa, Anjana, Ranjit Mohan, De Silva, Laksara, Hanif, Abu A. M., Hasan, Mehedi, Hossain, Md Mokbul, Indrawansa, Susantha, Jayamanne, Deepal, Jha, Sujeet, Kasturiratne, Anuradhani, Katulanda, Prasad, Khawaja, Khadija I., Kumarendran, Balachandran, Mrida, Malay K., Rajakaruna, Vindya, Chambers, John Campbell, Frost, Gary, Sassi, Franco, Miraldo, Marisa

“…Multivariate regression models were used to assess association of exposure to healthy and unhealthy food environments on waist circumference, BMI, and probability of obesity for the total sample and stratified by sex and income. Findings: The presence of a higher share of supermarkets in the neighbourhood was associated with a reduction in body size (BMI, β = - 3∙23; p < 0∙0001, and waist circumference, β = −5∙99; p = 0∙0212) and obesity (Average Marginal Effect (AME): −0∙18; p = 0∙0009). …”
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Growth hormone increases BDNF and mTOR expression in specific brain regions after photothrombotic stroke in mice by Sanchez-Bezanilla, Sonia, Beard, Daniel J., Hood, Rebecca J., Åberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jörgen, Ong, Lin Kooi

“…Upregulation of total-mTOR protein expression in the peri-infarct and thalamus suggests that this might be a pathway that is involved in the neurorestorative effects previously reported in these animals and warrants further investigation. These findings suggest region-specific mechanisms of action of GH treatment and provide further understanding for how GH treatment promotes neurorestorative effects after stroke.…”
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Foot care behaviours and associated factors among patients with type 2 diabetes: a cross-sectional study by Ang, Chin-Siang, Goh, Kelley Fann Ing, Lodh, Nandika, Qin, Vicky Mengqi, Liew, Huiling, Sidhu, Harvinder Raj Singh, Ng, Jun Jie, Subramaniam, Tavintharan, Tan, Elaine, Koh, Gerald Choon Huat, Best, James, Wong, Julian, Car, Josip, Ho, Andy Hau Yan, Venkataraman, Kavita

“…Additionally, more FC knowledge increased the likelihood by 20% (OR=1.21; 95% CI=1.10–1.33), and higher diabetes-related stress increased it by 1.03 times (OR=1.03; 95% CI=1.02–1.05). Conclusions: Our findings underscore the interplay of various factors influencing FC behaviours among individuals with diabetes and call for targeted interventions and tailored strategies to improve FC practices in this vulnerable population.…”
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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Concomitant with TDP-43 aggregation and proteolysis after prolonged arsenite exposure, GADD34-bound CK1ϵ catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD34−/− cells. Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1ϵ and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies.…”
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Offset-16QAM-based coherent WDM with multi-carrier group detection by Xiang, Meng, Fu, Songnian, Tang, M., Shum, P., Liu, Deming

“…Moreover, 0.5 dB required OSNR penalty at BER=10-3 is obtained given 18 GHz ADC bandwidth. Besides, we find that side carriers suffer from severer performance degradation than the central carrier with limited ADC resolution and only 0.08 dB and 0.2 dB required OSNR penalty at BER=10-3 are secured with 6 bits ADC resolution for central carrier and side carriers, respectively.…”
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The capabilities of Multiclass Support Vector Machine (MSVM) training algorithms in grading agarwood essential oil by Anis Hazirah ‘Izzati H., Al-Hadi, Siti Mariatul Hazwa, Mohd Huzir, Nurlaila, Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The agarwood essential was graded into five grades (low, medium low, upper low, medium high, and high) and six grades (low, medium low, upper low, medium high, high, and upper high). The findings of this paper show the confusion matrix for five grades and six grades have no mismatch between actual and predicted data. …”
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Experimental and Computational Advancements in Peptidomimetic Ligand Discovery by Lee, Michael Alan

“…At the same time, discovery tools for finding peptides that modify PPIs have evolved, including advances in affinity selection techniques and combinatorial chemistry. …”
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Revealing Structural and Spin-state Dependent Reactivity of Single Atom Catalysts (SACs) with Systematically Improvable Computational Tools by Jia, Haojun (贾皓钧)

“…The ML models demonstrate superior accuracy in predicting reaction energetics compared to traditional scaling relationships. The findings validate codoping as a powerful strategy for tuning the properties of SACs to achieve enhanced ORR performance. …”
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Shifting Paradigms: Data-Centric Approach for Marine Statics Correction using Symmetric Autoencoding by Kanniah, Brindha

“…This notable precision improvement using SymAE highlights how a streamlined data-centric paradigm outperforms the traditional model-centric paradigm of marine statics correction. This finding is pivotal as it is the foundation that lays the groundwork and opens the path towards the real-world deployment of SymAE for statics correction in challenging deepwater environments.…”
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Just Doing My Job: Normative Dimensions of Social Roles by Wells, Eliza

“…While many role-occupants find conflicts between roles and morality distressing, many others seem not to notice that there is a conflict at all. …”
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Exploring the utility of silane cross-linkers for synthesis of superhydrophobic antibacterial fabrics by Agrawal, Neha

“…Textiles are omnipresent materials which find various industrial and household applications in our everyday lives. …”
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Design, fabrication and characterization of organic-inorganic hybrid solar cells by Ahmed Ali Said Ahmed

“…Moreover, the literature review provides the information about different types of lead-free solar cells and their advantages and their drawbacks. The achieved findings in this thesis include the following: (1) Six NDI-based molecules have been designed and synthesized as electron transporting layers in inverted perovskite solar cells; (2) Two pyrene-based molecules were designed and synthesized as electron transporting layers; (3) The effect of sulfur position in pyrene-based molecules was investigated (4) Three N-type conjugated polymers were explored as electron transporting layer (5) The effect of embedded sp2-nitrogen in donor and acceptors of conjugated polymer was explored and (6) Tellurium tetraiodide was explored as a promising light absorber in solar cells. …”
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Creative ageing in Singapore : a population study on participatory arts engagement and wellbeing among adults aged 50 and above by Ma, Stephanie Hilary Xinyi

“…Respondents expressed that their greatest interest lies within the genre of culture and heritage arts, with a strong preference to engage in arts activities within the community, and to attend such activities with their family or friends. Findings from propensity score matching with t-test analyses revealed that respondents who passively engaged in the arts experienced better quality of life t(728) = 3.35, p = .0008, d = .25, self-perceived health t(728) = 2.21, p = .028, d = 0.16, and sense of belonging t(728) = 2.17, p = .028, d = 0.16, as compared to those who did not. …”
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Feature extraction from EEG signals and regularization for brain-computer interface by Mishuhina, Vasilisa

“…Secondly, this thesis proposes a novel approach time-frequency CSP (TFCSP) which decomposes the EEG signal into time stages and frequency components to find the robust and discriminative features for classification. …”
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Scaffold-mediated sustained, non-viral delivery of miR-219/miR-338 promotes CNS remyelination by Milbreta, Ulla, Lin, Junquan, Pinese, Coline, Ong, William, Chin, Jiah Shin, Shirahama, Hitomi, Mi, Ruifa, Williams, Anna, Bechler, Marie E., Wang, Jun, ffrench-Constant, Charles, Hoke, Ahmet, Chew, Sing Yian

“…Similarly within the scaffolds, miR-219/miR-338 samples contained significantly more myelin basic protein (MBP) signals (p < 0.01) and higher myelination index (p < 0.05) than Neg miR samples. These findings highlight the potential of this platform to promote remyelination within the CNS.…”
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TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to mediate seed oil biosynthesis by Kong, Que, Singh, Sanjay K., Mantyla, Jenny J., Pattanaik, Sitakanta, Guo, Liang, Yuan, Ling, Benning, Christoph, Ma, Wei

“…In addition, TCP4 repressed the AtWRI1-mediated transactivation of the promoters of fatty acid biosynthetic genes. Collectively, our findings suggest that TCP4 represses fatty acid biosynthetic gene expression through interaction with AtWRI1, leading to a reduction of AtWRI1-mediated seed oil accumulation.…”
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Multi-path region mining for weakly supervised 3D semantic segmentation on point clouds by Wei, Jiacheng, Lin, Guosheng, Yap, Kim-Hui, Hung, Tzu-Yi, Xie, Lihua

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Sensitivity study of weather research and forecasting physical schemes and evaluation of cool coating effects in Singapore by weather research and forecasting coupled with urban ca... by Zhou, Mandi, Long, Yongping, Zhang, Xiaoqin, Donthu, Eswara V. S. K. K., Ng, Bing Feng, Wan, Man Pun

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