Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Subsequently, the selected research projects that were carried out in the application of genetics and genetic technologies in cancer, especially breast cancer, infectious diseases and therapeutics, including genetic immunisation will be chronicled and highlighted. It is highly likely that human genetics research through the years will become an increasingly more integral component of medical research. …”
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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We carried out loss- and gain-of-function experiments in MIN6 and EndoC-bH1 cell lines. We analysed previously published mouse andhuman T2D data sets.Results:Bulk RNA-seq revealed thatb-cell dedifferentiation is associated with the induction of genes associated with epithelial-to-mesenchymal transition (EMT) in prediabetic (2-week-old) and diabetic (12-week-old) Tg7 mice. …”
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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior by Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Brauer, Bastian, Merino-Veliz, Nicolas, Droste, Rita, Arancibia, Felipe, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E., Bustos, Fernando J.

“…In cultured neurons, KO of VPS50 did not affect the number of synaptic vesicles but did cause mislocalization of the V-ATPase V1 domain pump and impaired synaptic activity, likely as a consequence of defects in vesicle acidification and vesicle content. …”
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Inferring electrospray emission characteristics from molecular dynamics and simulated retarding potential analysis by Schroeder, Madeleine, Gallud, Ximo, Petro, Elaine, Jia-Richards, Oliver, Lozano, Paulo C

“…We find that for these experimental data, temperatures of EMI-BF4 dimers likely range between 590 and 687 K while trimer temperatures are larger between 989 and 1092 K. …”
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Defects in β-cell Ca2+ dynamics in age-induced diabetes by Li, Luosheng, Trifunovic, Aleksandra, Köhler, Martin, Wang, Yixin, Petrovic Berglund, Jelena, Illies, Christopher, Juntti-Berggren, Lisa, Larsson, Nils-Göran, Berggren, Per-Olof

“…We show that these changes are likely to be accounted for by impaired mitochondrial function and to involve phospholipase C/inositol 1,4,5-trisphosphate–mediated Ca2+ mobilization from intracellular stores as well as decreased β-cell Ca2+ influx over the plasma membrane. …”
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Invited perspectives : how machine learning will change flood risk and impact assessment by Wagenaar, Dennis, Curran, Alex, Balbi, Mariano, Bhardwaj, Alok, Soden, Robert, Hartato, Emir, Mestav Sarica, Gizem, Ruangpan, Laddaporn, Molinario, Giuseppe, Lallemant, David

“…Overall, machine learning is likely to drastically improve future flood risk and impact assessments, but issues such as applicability, bias and ethics must be considered carefully to avoid misuse. …”
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Effects of user behaviors on accumulation of social capital in an online social network by Rykov, Yuri, Koltsova, Olessia, Sinyavskaya, Yadviga

“…Additionally, the share of local friends, the number of received likes and the duration of SNS use are associated with social capital indicators. …”
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Pollen geochronology from the Atlantic coast of the united states during the last 500 years by Christie, Margaret A., Bernhardt, Christopher E., Parnell, Andrew C., Shaw, Timothy Adam, Khan, Nicole S., Corbett, Dorbett Reide, García-Artola, Ane, Clear, Jennifer, Walker, Jennifer S., Donnelly, Jeffrey P., Hasse, Tobias R., Horton, Benjamin P.

“…Inconsistencies were likely related to the hyperlocality of pollen chronohorizons, mixing of salt marsh sediment, reworking of pollen from nearby tidal flats, misidentification of pollen signals, and inaccuracies in or misinterpretation of other age markers. …”
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Causal attribution, benefits sharing, and earnings management by Helikum, Lukas J., Tan, Hun-Tong, Xu, Tu

“…In Experiment 1, we predict and find that managers are more likely to manage earnings when the firm's underperformance is caused by an external event and misreported earnings benefit other employees besides the reporting manager. …”
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The impact of repeated notifications and notification checking mode on investors' reactions to managers’ strategic positive title emphasis by Chen, Wei, Tan, Hun-Tong, Wang, Elaine Ying

“…As a result, compared to a title without a strategic positive emphasis, we find that a title with a strategic positive emphasis is more likely to result in a favorable investment judgment when investors receive repeated notifications in a one-by-one mode than when they receive a notification for the first time. …”
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Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype by de Vos, Ivo J. H. M., Goggi, Julian L., Wilson, Gabrielle R., Stegmann, Alexander P. A., Amor, David J., Dunn, Norris Ray, Carney, Thomas James, Lockhart, Paul J., Coull, Barry J., van Steensel, Maurice A. M., Tao, Evelyn Yaqiong, Ong, Sheena Li Ming, Scerri, Thomas, Low, Chernis Guai Mun, Wong, Arnette Shi Wei, Grussu, Dominic, van Geel, Michel, Janssen, Renske, Bahlo, Melanie

“…This residual activity likely accounts for the mitigated phenotype observed in our patients. …”
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Leveling the playing field: the selection and motivation effects of tournament prize spread information by Cardinaels, Eddy, Chen, Clara Xiaoling, Yin, Huaxiang

“…We predict and find that when employees can select into tournaments of varying prize spreads (which proxies for an environment where prize spread information is available), high-ability employees are more likely than low-ability employees to select into the tournament with a larger prize spread. …”
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Cultured and popular literary circuits on Facebook: a case study of Singaporean print culture in social media by Sagun, Karryl Kim, Luyt, Brendan

“…Responses (comments and likes) were left out in the primary analysis, but were able to provide supplemental information that supported our initial investigation.Results. …”
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Classification of C. annuum and C. frutescens ripening stages: how well does deep learning perform? by Ibrahim, Zarina, Hanafi, Marsyita, Shafie, Siti Mariam, Syed Ahmad, Sharifah M.

“…Among all of the chilli variants, C. annuum and C. frustescents are the most prevalent and consistently liked variants in Asia, where it is appreciated for its strong taste and pungency. …”
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Drive-specific selection in multistable mechanical networks by Kedia, Hridesh, Pan, Deng, Slotine, Jean-Jacques, England, Jeremy L.

“…In equilibrium, a multistable system is more likely to be found in configurations with lower energy, but the presence of an external drive can alter the relative stability of different configurations in unexpected ways. …”
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Market Adoption of Healthy Buildings in the Office Sector: A Global Study from the Owner’s Perspective by Tan, Zhengzhen, Zheng, Siqi, Palacios, Juan, Hooks, Carl

“…Private equity funds and real estate investment trust (REIT) firms tend to focus on risk mitigation, while direct real estate investment firms are more likely to carry out the latter to position themselves as a leader within the real estate industry.…”
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Characterizing Cortex-Hippocampus Interactions During Language Processing by Lee, Jiachen Elizabeth

“…In patients with hippocampal damage, language is left largely intact [Vargha-Khadem et al., 1997], suggesting that the hippocampus is likely not necessary for language processing. Recent evidence, however, has shown that the hippocampus may serve functions outside its traditional roles in episodic memory and spatial navigation, and may generally aid in the encoding of relationships across time and space [Cohen and Eichenbaum, 1993]. …”
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Overturning of No-Tension Towers by Moir, Katherine

“…A comparison of the predictions for each of the two tower geometries shows that the predicted critical angles of overturning are very close, while the cylinder is likely to begin cracking at lower inclinations compared to rectangular towers. …”
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Semantic sensitive satellite image retrieval by Li, Yikun

“…Although various relevance feedback approaches have been proposed to bridge this gap, most of them can only work well under the assumption that regions belonging to the same or similar signal classes are very likely to share the same semantic concepts as well. …”
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Standalone immersion cooling for high performance servers by Liang, Wayne

“…Based on past recommendations, the author uses PTFE tape to effectively delay the evaporation of the coolant in the tank which likely affected the CPU temperature obtained. Additionally, a submersible pump is introduced to assess the hypothesis that forced convection is more efficient than natural convection. …”
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