Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol by Svensson, Jonas E., Bolin, Martin, Thor, Daniel, Williams, Pete A., Brautaset, Rune, Carlsson, Marcus, Sörensson, Peder, Marlevi, David, Spin-Neto, Rubens, Probst, Monika, Hagman, Göran, Morén, Anton Forsberg, Kivipelto, Miia, Plavén-Sigray, Pontus

“…Methods ERAP is a six-month-long, single-arm, open-label, phase IIa biomarker-driven study evaluating if the drug rapamycin can be repurposed to treat Alzheimer’s disease. …”
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Structural Characterization of La0.6Sr0.4CoO3−δ Thin Films Grown on (100)-, (110)-, and (111)-Oriented La0.95Sr0.05Ga0.95Mg0.05O3−δ by Ražnjević, Sergej, Drev, Sandra, Bumberger, Andreas E., Popov, Maxim N., Siebenhofer, Matthäus, Böhme, Christin, Chen, Zhuo, Huang, Yong, Riedl, Christoph, Fleig, Jürgen, Čeh, Miran, Kubicek, Markus, Zhang, Zaoli

“…Thin films were grown on single crystals of the perovskite material La0.95Sr0.05Ga0.95Mg0.05O3−δ cut in three different directions. …”
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Deep Optical Coding Design in Computational Imaging: A data-driven framework by Arguello, Henry, Bacca, Jorge, Kariyawasam, Hasindu, Vargas, Edwin, Marquez, Miguel, Hettiarachchi, Ramith, Garcia, Hans, Herath, Kithmini, Haputhanthri, Udith, Ahluwalia, Balpreet Singh, So, Peter, Wadduwage, Dushan N., Edussooriya, Chamira U.S.

“…Computational optical imaging (COI) systems leverage optical coding elements (CE) in their setups to encode a high-dimensional scene in a single or multiple snapshots and decode it by using computational algorithms. …”
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Who2chat: A Social Networking System for Academic Researchers in Virtual Social Hours Enabling Coordinating, Overcoming Barriers and Social Signaling by Park, Soya, Song, Jaeyoon, Karger, David R., Malone, Thomas W.

“…Who2chat allows academic researchers to create a research profile and express their research interests, find researchers with similar interests, overcome social barriers, and coordinate and start video chats, all within a single interface. We engaged in an iterative design process by deploying Who2chat at academic conferences. …”
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Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation by Mellado-Artigas, Ricard, Borrat, Xavier, Ferreyro, Bruno L., Yarnell, Christopher, Hao, Sicheng, Wanis, Kerollos N., Barbeta, Enric, Torres, Antoni, Ferrando, Carlos, Brochard, Laurent

“…The target trial was emulated using a single-center database (MIMIC-IV) which contains granular information about clinical status. …”
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Percutaneous Intratumoral Immunoadjuvant Gel Increases the Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer by Som, Avik, Rosenboom, Jan‐Georg, Wehrenberg‐Klee, Eric, Chandler, Alana, Ndakwah, Gabrielle, Chen, Eric, Suggs, Jack, Morimoto, Joshua, Kim, Jonathan, Mustafa, Abdul Rehman, Marcos‐Vidal, Asier, Fintelmann, Florian J., Basu, Arijit, Langer, Robert, Traverso, Giovanni, Mahmood, Umar

“…The poly‐lactic‐<jats:italic>co</jats:italic>‐glycolic acid‐polyethylene glycol‐poly‐lactic‐<jats:italic>co</jats:italic>‐glycolic acid (PLGA‐PEG‐PLGA)‐based amphiphilic copolymer gel's underlying micellar nature enables high drug concentration and a logarithmic release profile that is additive with the neo‐antigen release from cryoablation, requiring only a single injection. Rheological testing demonstrated the thermoresponsive increase in viscosity at body temperature and radio‐opacity via microCT. …”
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The Temperature Dependence of Hydrogen Bonds Is More Uniform in Stable Proteins: An Analysis of NMR h3JNC′ Couplings in Four Different Protein Structures by Alexandrescu, Andrei T., Dregni, Aurelio J.

“…The cis and trans states of the C-terminal domain from pore-forming toxin hemolysin ΙΙ (HlyIIC) arise from the isomerization of a single G404-P405 peptide bond. For P22i and CUS-3i, hydrogen bonds detected by NMR agree with those observed in the corresponding domains from cryoEM structures of the two phages. …”
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Research on Traditional Village Spatial Differentiation from the Perspective of Cultural Routes: A Case Study of 338 Villages in the Miao Frontier Corridor by Zhao, Weiqi, Xiao, Dawei, Li, Jing, Xu, Ziyu, Tao, Jin

“…This study shows that the spatial distribution of the traditional villages in the Miao Frontier Corridor is uneven, exhibiting a cluster structure with of a “single primary nucleus with multiple secondary nuclei”. …”
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SNARGs under LWE via Propositional Proofs by Jin, Zhengzhong, Kalai, Yael, Lombardi, Alex, Vaikuntanathan, Vinod

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Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…We validated the synergy in cell death using fluorescence-based and lysis-dependent inference of cell death kinetics assay, and validated the genetic dependencies by single-gene knockout experiments. Results Our combination screen identified SN-38/erlotinib as the drug pair with the strongest synergism. …”
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Scheduling Jobs with Work-Inefficient Parallel Solutions by Kuszmaul, William, Westover, Alek

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Decoding divergence in marine protistan communities: from strain diversity to basin biogeography by Krinos Quinn, Arianna Isabella

“…Specifically, strains of a single phytoplankton species revealed diversity relevant to a global ecosystem model. …”
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Recovery of Herschel-Bulkley Fluid Parameters from Video via Differentiable Simulations by Eastman, John M.

“…Our approach aims to accurately recover physical parameters and achieve high-fidelity 3D reconstructions from single-view videos of fluids, even those with complex rheological behaviors like shear thinning and thickening. …”
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Coherent Terahertz Control and Ultrafast Spectroscopy of Layered Antiferromagnets by Ilyas, Batyr

“…Finally, second harmonic generation spectroscopy with microscale spatial resolution, is employed to study the multiferroic material NiI₂, demonstrating its persistence down to the single atomic layer — a first of its kind. These findings and tools can potentially be extended to frustrated quantum magnets to control their magnetic phases and potentially detect their collective modes. …”
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On the non-microbial sources and sinks of dissolved metabolites in seawater by Germolus, Noah Paul

“…These chemicals are the flows of the “microbial loop”—the principle that most of the photosynthesized matter in the ocean is exchanged, respired, and restructured by single-celled organisms. Metabolites have critical biological utility, so they are considered extremely labile; estimates of the time each spends outside cells range from hours to days. …”
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Investigating cofactor transfer for a B₁₂-dependent enzyme by Duong, Alexander T.

“…The metallocofactors utilized by enzymes can range in complexity from single metal ions to organometallic cofactors well over 1000 Da. …”
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Imaging the initial condition of heavy-ion collisions and nuclear structure across the nuclide chart by Jia, Jiangyong, Giacalone, Giuliano, Bally, Benjamin, Brandenburg, James D., Heinz, Ulrich, Huang, Shengli, Lee, Dean, Lee, Yen-Jie, Loizides, Constantin, Li, Wei, Luzum, Matthew, Nijs, Govert, Noronha-Hostler, Jacquelyn, Ploskon, Mateusz, van der Schee, Wilke, Schenke, Bjoern

“…However, most approaches involve simultaneously determining both QGP properties and initial conditions from a single collision system, creating complexity due to the coupled contributions of these stages to the final-state observables. …”
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GCBF+: A Neural Graph Control Barrier Function Framework for Distributed Safe Multi-Agent Control by Zhang, Songyuan, So, Oswin, Garg, Kunal, Fan, Chuchu

“…We develop a novel theoretical framework to prove the safety of an arbitrary-sized MAS with a single GCBF. We propose a new training framework GCBF+ that uses graph neural networks to parameterize a candidate GCBF and a distributed control policy. …”
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Restoring product focus across the value stream through organizational restructuring by Pasqual, Jeffrey M. (Jeffrey Michael)

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15.568B Management Information Systems: Generating Business Value from Information Technology, Spring 2003 by Weill, Peter

“…For many firms IT is the single largest capital investment, often exceeding 50% of capital expenditure. …”
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