Development of CRISPR gene therapy for retinal degenerations by Fry, LE

“…Subsequently, an Ush2a-W3947X mouse model of the syndromic IRD Usher syndrome was developed and characterised. I finally used subretinal, AAV-delivered RNA base editors to successfully correct the molecular phenotype of the homozygous Ush2a-W3947X mouse.…”

The political psychology of personality and attitudes towards immigrants by Buettner, N

“…Forth, I switch perspectives and show that immigrants’ personalities, operationalized via the ten Big Five personality aspects, strongly shape natives’ preferences for said immigrants in an original conjoint experiment fielded in the United Kingdom. Fifth, and finally, I conclude this thesis by, again, highlighting the importance of personality psychology for studying political behavior more broadly and immigration attitudes more specifically with a special emphasis on both the institutional challenges and pushback from (some) political scientists with regards to this type of research.…”

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Importantly, results obtained in SCA14 iPSCs faithfully recapitulated the pathological findings observed in the patient post-mortem cerebellum. Finally, to determine the developmental changes in Purkinje cells, human Purkinje cells were generated from control and SCA14 iPSCs using a novel simplified protocol. …”

Direct measurement of magnetic monopole charge and transport dynamics by Hsu, C

“…The excellent agreement of the charge between theory and experiments marks the importance of entropic force in the monopole transport. Finally, the overall work and the potential future exploration is summarized in Chapter 7.…”

Evolution of an extracellular pathogen recognition mechanism in Solanaceae by Kourelis, J

“…This potentially enables future engineering of this molecular mechanism for an altered recognition spectrum. Finally, using the proteome derived from re-annotated gene models of the plant model organism <em>Nicotiana benthamiana</em>, I show that the apoplast is enriched for enzymes with hydrolytic functions.…”

CipherTrace: automatic detection of ciphers from execution traces by Hassanin, MA

“…The synthetic information can be categorized as raw (i.e., Platform-driven or Assembly-driven), or lifted (i.e., LLVM-driven). Finally, we report the findings, observations, limitations, and assert the feasibility and scalability of the concept, the dynamic analysis approach, as well as the technique applied to identify cryptographic (crypto) elements to classify a cipher. …”

Clouds and hazes in Saturn's troposphere and stratosphere by Merlet, CTC

“…The north-south temperature variations in the troposphere are obtained from the analysis of thermal infrared data measured with the Composite InfraRed Spectromete (CIRS) instrument on board Cassini. Finally, VIMS near-infrared data at 0.8-3.5 and 4.5-5.1 <em>μ</em>m are combined in order to obtain a cloud and haze model coherent with both wavelength ranges.…”

18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…</p> <p><b>Chapter 4</b> investigates the ¹⁸F-labelling of α,α-difluoro-α-aryloxyacetic acid, a class of substrate that can serve as a versatile intermediate which can undergo various decarboxylative functionalisation reactions to afford a wide range of novel ¹⁸F labelled α fluorinated aryl ethers. Finally, Chapter 5 gives full experimental procedures and characterisation data for all compounds.…”

DEWP: deep expansion learning for wind power forecasting by Fan, W, Fu, Y, Zheng, S, Bian, J, Zhou, Y, Xiong, H

“…Accurate wind power forecasting (WPF) is then better achieved through fine-grained outputs by continuously removing stack residues and accumulating useful stack forecasts. Finally, we present extensive experiments in the real-world WPF application on two datasets from two different turbines, in order to demonstrate the effectiveness of our approach.…”

Unravelling giant molecular clouds by Liang, F

“…A subset of GMCs have their angular momenta aligned with the large-scale galactic rotation.</p> <p>Finally, in the MW CMZ, I study the gas-structure dendrogram across a large dynamical range (1–100 pc), primarily with ALMA HNCO(4-3) observations at 0.7 pc resolution. …”

Surface engineering of layered double hydroxides for advanced applications by Laney, K

“…</p> <br> <p><strong>Chapter Six</strong> presents the overall conclusion of this thesis.</p> <br> <p>Finally, details of the experimental procedures performed are included in <strong>Chapter Seven</strong>.…”

English newspaper coverage of financial education on old age savings by Ng, Chooi Fun

“…Through this study, the findings could be used (1) as input to enhance policy making decisions in terms of setting, adopting and implementing a standardized FE Curriculum for adult Malaysians, (2) as a basis to improve the cooperation between various stakeholders and FE on OAS Providers, (3) to support the financial education initiatives to include all segments of adult Malaysians facing different financial circumstance and preparing for different life goals and finally (4) to increase awareness on the need to expand the current initiatives undertaken by Malaysian newspapers to include all relevant FE on OAS Themes, FE on OAS Providers, all segment of population using various methods of presenting the contents in the articles. …”
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Enhanced intrusion detection model based on principal component analysis and variable ensemble machine learning algorithm by John, Ayuba, Isnin, Ismail Fauzi, Madni, Syed Hamid Hussain, Muchtar, Farkhana

“…Secondly, PCA is used for feature selection, and a LogitBoost classifier algorithm can be used for multiclass classification and acts as an additive tree regression to compensate for the PCA's weakness by minimizing the Logistic Loss to provide an optimal classifier output. Finally, the low variance ability of RandomForest, which employs the bagging approach, is applied to eliminate overfittings. …”
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Semantic scene understanding on 3D point clouds by Dong, Shichao

“…Robotic techniques have automated many processes in production lines. However, in flexible production scenarios, certain tasks cannot yet be fully handled by robots and still require human involvement. …”
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React Application Architecture for Production : Learn Best Practices and Expert Tips to Deliver Enterprise-Ready React Web Apps / by Alickovic, Alan, author 656263

“…The book will also share best practices for testing, securing, and packaging your app in a structured way before finally deploying your app with scalability in mind. …”
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Atmospheric characterization of cold exoplanets using a 1.5-m coronagraphic space telescope by Maire, Anne-Lise, Galicher, Raphael, Boccaletti, Anthony, Baudoz, Pierre, Schneider, Jean, Stam, Daphne, Cahoy, Kerri, Traub, Wes

“…It would also analyze cloud and surface coverage of super-Earths of radius 2.5 Earth radii at 1 AU. Finally, we determine the potential targets in terms of planet separation, radius and distance for several stellar types. …”
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The Relationship between Linguistic Representations in Biological and Artificial Neural Networks by Kauf, Carina

“…I find evidence for a generalized reliance of language comprehension on syntactic processing, contra claims that language comprehension relies on shallow/associative processing, and for only a superficial encoding of sentence meaning. Finally, I systematically investigate what aspects of language inputs are critical for LM-to-brain alignment. …”
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Trouble on the Range: When Does a National Park Become a Bison Zoo? by Hartley, Sophia

“…Scientists thought that finally, the northern range’s native flora and fauna might have a chance to recover. …”
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Textile Macroelectronics: Architecting Sensate and Computational Fabrics across Scales by Wicaksono, Irmandy

“…These efforts have led to unique power, interconnection, and networking paradigms that allow us to transition from application-specific sensate textiles to generic computational fabrics that can be tailored and programmed for various applications. Finally, through these collective and complementary efforts, I aim to demonstrate an ecosystem of fabric artifacts that will lead us toward an Electronic Textile Gaia—a vision where sensing and intelligence are seamlessly interconnected and integrated into the fabric of everyday life, from in-body, on-body, room-scale, to architectural textiles, for applications ranging from physiological and physical activity monitoring to interactive media and built environments.…”
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The Ethics within Metaphysics by Impagnatiello, Michele Odissea

“…Then, I argue that the Humean/Anti-Humean debate also arises when it comes to metaphysical and ethical laws. Finally, I argue in favor of the Anti-Humean conception of metaphysical and ethical laws, both adapting standard arguments used in the debates about laws of nature, and with new arguments specific to metaphysics and ethics. …”
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