N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 by Zou, Shui, Toh, Joel D. W., Wong, Kendra H. Q., Gao, Yong-Gui, Hong, Wanjin, Woon, Esther C. Y.

“…Remarkably, through the RNA-remodelling effects of m6A, the demethylases were able to discriminate substrates with very similar nucleotide sequences. Our findings provide novel insights into the biological functions of m6A modifications. …”
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Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice by Loke, Mun Fai, Vadivelu, Jamuna, Tan, Tuan Lin, Wong, Whye Yen, Khosravi, Yalda, Seow, Shih Wee, Amoyo, Arlaine Anne, Chiow, Kher Hsin, Poh, Qian Hui, Sentosa, Ignatius Mario Doli, Bunte, Ralph M., Pettersson, Sven

“…However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. …”
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Controllable broadband multicolour single-mode polarized laser in a dye-assembled homoepitaxial MOF microcrystal by He, Huajun, Cui, Yuanjing, Li, Hongjun, Shao, Kai, Chen, Banglin, Qian, Guodong

“…Furthermore, the resulting three-colour single-mode lasing possesses the largest wavelength coverage of ~186 nm (ranging from ~534 to ~720 nm) ever reported. These findings may open a new route to the exploitation of multicolour single-mode micro/nanolasers constructed by MOF engineering for photonic and biochemical applications.…”
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The cancellation heuristic in intertemporal choice shifts people's time preferences by Sengupta, Arjun, Savani, Krishna

“…Furthermore, we provide evidence of the underlying mechanism-people's intertemporal decisions shifted to a greater extent in the cancellation condition, particularly if their marginal utility diminished faster. The findings indicate that two features of human psychology-diminishing marginal utility and the cancellation heuristic-can be simultaneously utilized to nudge people to make decisions that would be better for them in the long run.…”
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Mechanisms of Yersinia YopO kinase substrate specificity by Lee, Wei Lin, Singaravelu, Pavithra, Wee, Sheena, Xue, Bo, Ang, Khay Chun, Gunaratne, Jayantha, Grimes, Jonathan M., Swaminathan, Kunchithapadam, Robinson, Robert C.

“…Using artificial substrates we clarified YopO’s substrate length requirements and its phosphorylation consensus sequence. These findings provide fresh insight into the mechanism of the YopO kinase and demonstrate that YopO executes a specific strategy targeting actin-modulating proteins, across multiple functionalities, to compete for control of their native phospho-signaling, thus hampering the cytoskeletal processes required for macrophage phagocytosis.…”
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Identification and characterization of roseltide, a knottin-type neutrophil elastase inhibitor derived from hibiscus sabdariffa by Nguyen, Giang Kien Truc, Tam, James Pingkwan, Loo, Shining, Kam, Antony, Xiao, Tianshu, Liu, Chuan Fa

“…Taken together, our findings demonstrate that roseltide rT1 is a novel knottin-type neutrophil elastase inhibitor with therapeutic potential for neutrophil elastase associated diseases.…”
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Valley-optical absorption in planar transition metal dichalcogenide superlattices by Hashemi, R., Shojaei, S., Rezaei, B., Liu, Zheng

“…Moreover, the role of incident light angle and light polarization were studied in details at different valleys of [Formula: see text] and [Formula: see text]. The most important finding is that by changing the polarization of incident light, it is possible to increase the absorption coefficients of [Formula: see text] and [Formula: see text] valleys by up to 30 times. …”
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Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data by Xu, Xuhai, Yao, Bingsheng, Dong, Yuanzhe, Gabriel, Saadia, Yu, Hong, Hendler, James, Ghassemi, Marzyeh, Dey, Anind K., Wang, Dakuo

“…We highlight the important ethical risks accompanying this line of research.…”
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Evaluating slope stability using regional water balance analysis by Rangarajan, Saranya

“…Subsequently, the relationship between FOS and VWC was established using a linear regression line for the selected slopes. Vegetations play an important role in slope stability. …”
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The artifice that endures the burden of the past : analysing memory in Angela Carter's fictional works. by Yuvaneswari.

“…By moving from a more conspicuously defined model of memory to a more indeterminate one, this essay works towards finding a continuum within Carter’s general line of writing which situates destabilisation and demystification at its nexus. …”
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To study the current innovations and their effects on the maritime industry by Tay, Jadeline Bi Hui

“…This research can help companies to make investments in current innovations to which is in line with companies’ specific objective and match companies’ specific needs. …”
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The role of POPX2 in the regulation of hippo pathway by Muhammad Bakhait Rahmat

“…Furthermore, CRISPR knock-out of POPX2 in the highly invasive breast cancer cell line MDA-MB-231, X2KO cells, showed lower YAP/TAZ protein levels both in the cytoplasm as well as in the nucleus. …”
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Target Design and Optimizations for Spent Fuel Transmutation by Tukharyan, Grigor

“…A proposed tank design with a lead/Tc-99 target that is surrounded by LLFP pins and heavy water is considered for the spallation study. …”
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Interplanetary space weather effects on Lunar Reconnaissance Orbiter avalanche photodiode performance. by Clements, E. B., Carlton, A. K., Joyce, C. J., Schwadron, N. A., Spence, H. E., Sun, X., Cahoy, K.

“…We compare noise data from the Lunar Reconnaissance Orbiter (LRO) Lunar Orbiter Laser Altimeter (LOLA) SiAPDs with radiation measurements from the onboard Cosmic Ray Telescope for the Effects of Radiation (CRaTER) instrument. We did not find any evidence to support radiation as the cause of changes in detector threshold voltage during radiation storms, both for transient detector noise and long-term average detector noise, suggesting that the approximately 1.3 cm thick shielding (a combination of titanium and beryllium) of the LOLA detectors is sufficient for SiAPDs on interplanetary missions with radiation environments similar to what the LRO experienced (559 cGy of radiation over 4 years).…”
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Actionable Auditing: Investigating the Impact of Publicly Naming Biased Performance Results of Commercial AI Products by Buolamwini, Joy, Raji, Inioluwa Deborah

“…Within 7 months of the original audit, we find that all three targets released new API versions. …”
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The International Affiliation Network of YouTube Trends by Platt, Edward, Bhargava, Rahul, Zuckerman, Ethan

“…Consistent with existing work on video popularity, we find that long trending times within one nation do not necessarily translate to reaching a wide global audience. …”
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Association between COVID-19 outcomes and mask mandates, adherence, and attitudes by Adjodah, Dhaval, Dinakar, Karthik, Chinazzi, Matteo, Fraiberger, Samuel P., Pentland, Alex, Bates, Samantha, Staller, Kyle, Vespignani, Alessandro, Bhatt, Deepak L.

“…These effects are large, corresponding to 14% of the highest recorded number of cases, 13% of deaths, and 7% of admission proportion. We also find that mask mandates are linked to a 23.4 percentage point increase in mask adherence in four diverse states. …”
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Branch-and-bound performance estimation programming: a unified methodology for constructing optimal optimization methods by Das Gupta, Shuvomoy, Van Parys, Bart P. G., Ryu, Ernest K.

“…Finally, we use the BnB-PEP methodology to find proofs with potential function structures, thereby systematically generating analytical convergence proofs.…”
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Probing axion-like particles at the Electron-Ion Collider by Balkin, Reuven, Hen, Or, Li, Wenliang, Liu, Hongkai, Ma, Teng, Soreq, Yotam, Williams, Mike

“…In a prompt-decay search, we find that the EIC can set the most stringent bound for <jats:italic>m</jats:italic><jats:sub><jats:italic>a</jats:italic></jats:sub> ≲ 20 GeV and probe the effective scales Λ ≲ 10<jats:sup>5</jats:sup> GeV. …”
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Petz recovery from subsystems in conformal field theory by Vardhan, Shreya, Wei, Annie Y., Zou, Yijian

“…In the case where A and C are far apart, we find a surprising non-commutativity of the replica trick with the OPE limit. …”
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