Selective targeting of MYC mRNA by stabilized antisense oligonucleotides by Gill, Taylor, Wang, Haichuan, Bandaru, Raj, Lawlor, Matthew, Lu, Chenyue, Nieman, Linda T, Tao, Junyan, Zhang, Yixian, Anderson, Daniel G, Ting, David T, Chen, Xin, Bradner, James E, Ott, Christopher J

“…MYCASO treatment of cancer cell lines leads to significant inhibition of cellular proliferation while specifically perturbing MYC-driven gene expression signatures. …”
Get full text

Unsupervised Learning for Generative Scene Editing and Motion by Fang, David S.

“…In this thesis, we propose two distinct lines of unsupervised learning work with generative applications: 1) BlobGSN and 2) optical flow estimation and flow generation with diffusion models. …”
Get full text

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling by Witmer, Kathrin, Schmid, Christoph D., Brancucci, Nicolas M. B., Luah, Yen-Hoon, Preiser, Peter Rainer, Bozdech, Zbynek, Voss, Till S.

“…Here, we analysed promoters of upsA, upsB and upsC var, rifA1-type rif, stevor, phist and pfmc-2tm genes and investigated their role in endogenous gene transcription by comparative genome-wide expression profiling of transgenic parasite lines. We find that the three major var promoter types are functionally equal and play an essential role in singular gene choice. …”
Get full text
Get full text

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…Here, we present a rapid and universal experimental approach to functionally analyze a CRISPR-targeted cell population that does not involve generating clonal lines. As a simple readout, we leverage the CRISPR-induced genetic heterogeneity and use sequencing to identify how different genotypes are enriched or depleted in relation to the studied cellular behavior or phenotype. …”
Get full text

Elucidating the size-dependency of in vitro digested polystyrene microplastics on human intestinal cells health and function by Ma, Yiyuan, Koh, Cheryl Jie Yan, Lim, Hong Kit, Shi, Pujiang, Tay, Chor Yong

“…Herein, the potential deleterious biological effects of pristine and in vitro digested polystyrene (PS) MPs of varying sizes (i.e., 0.1, 1, and 10 µm) are systematically examined over a wide concentration range of 25–400 µg mL−1 on two human intestinal cell lines, namely Caco-2 and NCM 460. Specifically, significant internalization of 0.1 and 1 µm PS -MPs have been observed in both cell types 24 h postexposure. …”
Get full text

Label-free assessment of differentiation efficiency in iPSC-derived spinal cord progenitor cells via Magnetic Resonance Relaxometry (MRR) by Tan, Jerome Zu Yao, Chen, Jiahui, Roxby, Daniel, Chooi, Wai Hon, Nguyen, Tan Dai, Ng, Shi-Yan, Chew, Sing Yian, Han, Jongyoon

“…In this study, human iPSCs derived from Cord Lining Endothelial cells were differentiated into Spinal-cord Progenitor Cells (SCPCs) through a 10-day process. …”
Get full text
Get full text

Flexible integrated sensor with asymmetric structure for simultaneously 3D tactile and thermal sensing by Wang, Yongqing, Sun, Kun, Zhang, Qisheng, Yu, Samson Shenglong, Han, Boon Siew, Wang, Jianpeng, Zhao, Mingyan, Meng, Xianglin, Chen, Sicheng, Zheng, Yuanjin

“…The resistive thermal sensors are fabricated with serpentine lines and possess stable heat-sensing performance (165 mV/°C) under shape deformation conditions. …”
Get full text

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin by Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng

“…In addition, ADE-mediated dengue virus infection of human cell lines and primary PBMCs was inhibited. In a time-of-drug-addition study, luteolin was found to reduce infectious virus particle formation, but not viral RNA synthesis, in Huh-7 cells. …”
Get full text
Get full text

Mythical heroines : the appropriation of myth in reconstructing female identities in ethnic American literature by Goh, I-Mei.

“…The three literary texts being investigated along these lines are Maxine Hong Kingston’s The Woman Warrior, Bharati Mukherjee’s Jasmine and Toni Morrison’s Beloved. …”
Get full text
Get full text

Functional analysis of root-preferential oil palm metallothionein promoter in tobacco by Masura, Subhi Siti, Shaharuddin, Noor Azmi, Masani, Mat Yunus Abdul, Chan, Kuang-Lim, Low, Eng-Ti Leslie, Chan, Pek-Lan, Rahmah, Abdul Rahman Siti, Amiruddin, Nadzirah, Abdullah, Mohd Puad, Azzeme, Azzreena Mohamad, Parveez, Ghulam Kadir Ahmad, Abd Rasid, Omar

“…Stable functional characterisation of tobacco transgenic lines using the T1 generation showed that a deletion construct, designated as RSP-2D (1107 bp), directed strong GUS expression at all stages of root development, particularly in mature roots. …”

Determinants of Expatriate Manager Failures in the International Assignment by Mansor, Mohd Fitri, Abd Hamid, Nurzawani, Kamil, Syahida, Abu, Noor Hidayah

“…The international assignment requires an organization send their staff abroad for high potential career development, to coordinate global lines of business, transfer the organization knowledge in abroad, expand into new markets worldwide and also manage an international subsidiary. …”
Get full text

A type of novel energy harvesting device by Deng, J

“…However, these traditional energy sources are impractical for powering wireless devices due to their inherent limitations, e.g., the high setup cost of wiring power and the finite life span of batteries. In view of these facts, more attentions have been drawn on vibration energy sources existing in ambient environment where sensors operate. …”

Power system modeling and simulation by Luo, Yishi

“…The dissertation initially develops a equivalent model under steady state and dynamic state with implement of parameters from PES-TR19, then the power flow calculation and dynamic contingency analysis including overloading, underloading, tripping of tie lines and changes in load composition are proceeded, finally, the white paper emphasizes on analyzing the rotor angle, frequency, voltage stability of some elements including generators, bus bars in Nordic-74 test system. …”
Get full text

Search in location based social network by Lew, Stephanie Yin Hui.

“…The project can be potentially expanded to support other kinds of geospatial shapes such as polygons or lines, apart of venue points and also other types of spatial querying such as collective or relevant region querying that returns relevant groups of spatial objects.…”
Get full text

Website performance study by Qian, Lei

“…Taking into consideration customers’ high expectation of web application performance and potential negative consequences brought by poor performance, this report offers a comprehensive range of solutions to enhance web performance so as to perfect end-user experiences and further boost business bottom lines where applicable. The experiment was carried out on the self-built blog web application. …”
Get full text

Primary intestinal epithelial cell response to Helicobacter hepaticus in an ex vivo setting by Alrawaf, S

“…<p>Epithelial cells lining the intestinal mucosa play a critical role in mucosal immune homeostasis. …”

“Or they could just not use it?”: the dilemma of AI disclosure for audience trust in news by Toff, B, Simon, FM

“…We test whether audiences in the United States, where trust is particularly polarized along partisan lines, perceive news labeled as AI-generated as more or less trustworthy. …”

Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories by Dai, Y, Zhong, Y, Liu, H, Pan, R, Yuan, L, Du, J, Li, M, Wang, X, Shi, C, Liu, G, Zhu, P, Shimeld, S, Zhou, X, Li, G

“…We characterized cell specification at the mechanistic level and generated mutant lines to examine the function of five key transcription factors involved in neural specification. …”

Energy management of microgrids by Ju, Chengquan

“…Large-scale energy storage systems have provided promising potentials for multiple applications in microgrids by providing additional spinning reserve, regulating voltage, frequency and power factors, as well as offering economic benefits by participating into demand response and facilitating the integration of renewable energy sources (RESs). …”
Get full text

A deep learning-based fault detection and classification in smart electrical power transmission system by Khaleefah, Shihab Hamad, Mostafa, Salama A., Gunasekaran, Saraswathy Shamini, Khattak, Umar Farooq, Siti Salwani, Yaacob, Alanda, Alde

“…Electrical Power Transmission Networks (EPTN) are made of many complex, dynamic, and interrelated components. The transmission lines are essential components of the EPTN, and their fundamental duty is to transport electricity from the source area to the distribution network. …”
Get full text