XFEL serial crystallography reveals the room temperature structure of methyl-coenzyme M reductase by Ohmer, Christopher J, Dasgupta, Medhanjali, Patwardhan, Anjali, Bogacz, Isabel, Kaminsky, Corey, Doyle, Margaret D, Chen, Percival Yang-Ting, Keable, Stephen M, Makita, Hiroki, Simon, Philipp S, Massad, Ramzi, Fransson, Thomas, Chatterjee, Ruchira, Bhowmick, Asmit, Paley, Daniel W, Moriarty, Nigel W, Brewster, Aaron S, Gee, Leland B, Alonso-Mori, Roberto, Moss, Frank, Fuller, Franklin D, Batyuk, Alexander, Sauter, Nicholas K, Bergmann, Uwe, Drennan, Catherine L, Yachandra, Vittal K, Yano, Junko, Kern, Jan F, Ragsdale, Stephen W

“…In celebration of the seminal contributions of inorganic chemist Dick Holm to our understanding of nickel-based catalysis, we are honored to announce our findings in this special issue dedicated to this remarkable pioneer of bioinorganic chemistry.…”
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Screening of the PA14NR Transposon Mutant Library Identifies Genes Involved in Resistance to Bacteriophage Infection in Pseudomomas aeruginosa by Ho, Peiying, Dam, Linh Chi, Koh, Wei Ren Ryanna, Nai, Rui Si, Nah, Qian Hui, Rajaie Fizla, Faeqa Binte Muhammad, Chan, Chia Ching, Aung, Thet Tun, Goh, Shin Giek, Fang, You, Lim, Zhining, Koh, Ming Guang, Demott, Michael, Boucher, Yann Felix, Malleret, Benoit, Gin, Karina Yew-Hoong, Dedon, Peter, Moreira, Wilfried

“…This study highlights the potential of transposon mutant libraries and forward-genetic screens in identifying key genes involved in phage-host interactions and resistance mechanisms. These findings support the development of innovative strategies for combating antibiotic-resistant pathogens.…”
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Comparative systems biology analysis to study the mode of action of the isothiocyanate compound iberin on pseudomonas aeruginosa by Givskov, Michael, Nielsen, Thomas E., Tolker-Nielsen, Tim, Tan, Sean Yang-Yi, Liu, Yang, Chua, Song Lin, Vejborg, Rebecca Munk, Jakobsen, Tim Holm, Chew, Su Chuen, Li, Yingying, Yang, Liang

“…Taken together, the findings suggest that the mode of QS inhibition in iberin is through downregulation of the Gac/Rsm QS network, which in turn leads to the repression of QS-regulated virulence factors, such as pyoverdine, chitinase, and protease IV. …”
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Omega-3 (ω-3) and social skills interventions for reactive aggression and childhood externalizing behavior problems : a randomized, stratified, double-blind, placebo-controlled, fa... by Raine, Adrian, Ang, Rebecca P., Choy, Olivia, Hibbeln, Joseph R., Ho, Ringo Moon-Ho, Lim, Choon Guan, Lim-Ashworth, Nikki S. J., Ling, Shichun, Liu, Jean C. J., Ooi, Yoon Phaik, Tan, Yi Ren, Fung, Daniel S. S.

“…Effect sizes (d) were small, ranging from 0.17 to 0.31. Conclusions: Findings provide some initial support for the efficacy of ω-3 in reducing reactive aggression over and above standard care (medication and parent training), but yield only preliminary and limited support for the efficacy of ω-3 in reducing overall externalizing behavior in children. …”
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Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality by Kashyap, Rajan, Bhattacharjee, Sagarika, Yeo, Thomas B. T., Chen, Annabel Shen-Hsing

“…Gender differences were also significant. Altogether the findings suggested that subtypes exist even in healthy control population, and comparison studies (case vs. control) need to be mindful of it.…”
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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…Immunoblot analyses confirmed these findings. Finally, relative to young sham mice the cell type-specific profile of genes in both young BCAS and old sham animals further revealed common cell-specific genes. …”
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Monolayer tungsten disulfide in photonic environment : angle-resolved weak and strong light-matter coupling by Zhang, Xuewen, Wu, Lishu, Wang, Xu, He, Silin, Hu, Hanwei, Shi, Guangchao, Zhang, Xingwang, Shang, Jingzhi, Yu, Ting

“…By embedding 1L-WS2 into a dielectric microcavity, strong exciton-photon coupling results in the formation of lower and upper polariton branches with an appreciable Rabi splitting of 34 meV at room temperature, where the observed blueshift of the lower polariton branch is indicative of the enhanced polariton-polariton scattering. Our findings highlight the effect of dielectric environment on angle-resolved optical response of exciton-photon interactions in a two-dimensional semiconductor, which is helpful to develop practical TMD-based architectures for photonic and polaritonic applications. …”
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Graphdiyne/graphene heterostructure: a universal 2D scaffold anchoring monodispersed transition-metal phthalocyanines for selective and durable CO₂ electroreduction by Gu, Huoliang, Zhong, Lixiang, Shi, Guoshuai, Li, Jiaqiang, Yu, Ke, Li, Jiong, Zhang, Shuo, Zhu, Chenyuan, Chen, Shaohua, Yang, Chunlei, Kong, Ya, Chen, Chen, Li, Shuzhou, Zhang, Jin, Zhang, Liming

“…The usage of the GDY/G heterostructure as a scaffold can be further extended to other organometallic complexes beyond CoPc. Our findings lend credence to the prospect of the GDY/G hybrid contributing to the design of single-molecule dispersed CO2R catalysts for sustainable energy conversion.…”
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Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation by Wu, Zhuoran, Setyawati, Magdiel Inggrid, Lim, Hong Kit, Ng, Kee Woei, Tay, Chor Yong

“…Transcriptome profiling, bioinformatics analysis and siRNA gene knockdown experiments revealed the nuclear factor erythroid 2-related factor 2 (Nrf2) as the key modulator of the ZnO NP-induced drug resistance. Our findings suggest that a ROS-inducing ENM can emerge as a nano-stressor, capable of regulating the chemosensitivity of colon cancer cells.…”
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Super-resolution imaging of photogenerated charges on CdS/g-C₃N₄ heterojunctions and its correlation with photoactivity by Wu, Shuyang, Lee, Jinn-Kye, Lim, Pei Chong, Xu, Rong, Zhang, Zhengyang

“…The photoactive species (i.e., e- and h+) were found to be preferentially distributed at the two end segments of CdS nanorods and the edge boundaries of g-C3N4. Therefore, our findings shed more light on the charge distribution and photocatalytic heterogeneity of composite materials at the nanoscale. …”
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Parent-infant affect synchrony during social and solo play by Kidby, Sayaka, Neale, Dave, Wass, Sam, Leong, Victoria

“…While our sample was small and from a homogeneous population (e.g. white, highly educated parents), limiting the implications of the findings, these results demonstrate that maternal active engagement in playful interaction with her infant affords, increases, and extends infant positive affect and parent-infant positive affect synchrony, providing insights into how the social context modulates infants' affective experiences. …”
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2D-3D perovskite memristor with low energy consumption and high stability for neural morphology calculation by Sun, Kaixuan, Wang, Qingrui, Zhou, Long, Wang, Jingjuan, Chang, Jingjing, Guo, Rui, Tay, Beng Kang, Yan, Xiaobing

“…Moreover, this perovskite-based artificial synapse has ultra-low power consumption due to the switchable p-i-n structure in organic-inorganic halide perovskites. Our finding highlights the immense application potential of the 2D-3D perovskite memristor in the future neuromorphic computing system.…”
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Constrained neuro fuzzy inference methodology for explainable personalised modelling with applications on gene expression data by Singh, Balkaran, Doborjeh, Maryam, Doborjeh, Zohreh, Budhraja, Sugam, Tan, Samuel, Sumich, Alexander, Goh, Wilson, Lee, Jimmy, Lai, Edmund, Kasabov, Nikola

“…These genes are linked to cognitive ability and impulsive behaviour. Our findings suggest a significant starting point for further research into the biological role of cognitive and impulsivity-related differences. …”
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Valley-optical absorption in planar transition metal dichalcogenide superlattices by Hashemi, R., Shojaei, S., Rezaei, B., Liu, Zheng

“…Moreover, the role of incident light angle and light polarization were studied in details at different valleys of [Formula: see text] and [Formula: see text]. The most important finding is that by changing the polarization of incident light, it is possible to increase the absorption coefficients of [Formula: see text] and [Formula: see text] valleys by up to 30 times. …”
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LKAW: a robust watermarking method based on large kernel convolution and adaptive weight assignment by Zhang, Xiaorui, Jiang, Rui, Sun, Wei, Song, Aiguo, Wei, Xindong, Meng, Ruohan

“…Robust watermarking requires finding invariant features under multiple attacks to ensure correct extraction. …”
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Impact of China's financial development on the sustainable development goals of the Belt and Road Initiative participating countries by Li, Chenggang, Zhao, Gang, Koh, Keumseok Peter, Xu, Zhenci, Yue, Mu, Wang, Weiyan, Tan, Yuanyuan, Wu, Liang

“…To address this gap, we utilized panel regression models to quantitatively assess the impact of China’s financial development scale, structure, and efficiency on the SDGs of the BRI participating countries, and adopted Geographically and Temporally Weighted Regression (GTWR) model to explore the spatial-temporal effects of China’s financial development scale, structure, and efficiency on the SDGs of the BRI participating countries. Our findings indicate that China’s financial development has significantly promoted the SDGs of the BRI participating countries. …”
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Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy by Zhu, Caigang, Chen, Shuo, Chui, Christopher Hoe-Kong, Tan, Bien-Keem, Liu, Quan

“…Meanwhile, several physiologically relevant parameters including hemoglobin oxygenation, total hemoglobin concentration, and redox ratio indicators estimated from diffuse reflectance and autofluorescence spectra show distinctively different trends over time for nonviable and viable skin. Conclusions: These findings will be helpful to clinicians for making a precise judgment on flap viability. …”
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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Ethnic differences in knowledge, attitudes, and practices related to dietary salt intake and association with hypertension in Malaysia: a multi-centre cross-sectional study by Chia, Yook Chin, Ching, Siew Mooi, Chew, Ming Tsuey, Devaraj, Navin Kumar, Oui, Jethro Ee Keat, Lim, Hooi Min, Chew, Bee Nah, Mohamed, Mohazmi, Ooi, Pei Boon, Cheng, Maong Hui, Beh, Hooi Chin, Chung, Felicia Fei-Lei

“…Those who were unaware of the difference between salt and sodium and who reported not reading salt labels had higher odds of having elevated blood pressure. These findings demonstrate that while there is a suboptimal translation of salt knowledge into practice in Malaysia, with significant differences in KAP observed between ethnic groups, the potential of improving health outcomes by improving the clarity and awareness of salt labels is substantial. …”