Synthetic post-translational protein modification as a switch for activity by Faulkner, SC

“…Dha chemistry was once again employed to install O- and N-linked GlcNAc mimics in the complement determining region (CDR) of a nanobody cAbLys3, with the aim of reversibly blocking its antigen binding capacity. …”

Subretinal timrepigene emparvovec in adult men with choroideremia: a randomized phase 3 trial by MacLaren, RE, Fischer, MD, Gow, JA, Lam, BL, Sankila, E-MK, Girach, A, Panda, S, Yoon, D, Zhao, G, Pennesi, ME

“…<p>Choroideremia is a rare, X-linked retinal degeneration resulting in progressive vision loss. …”

Self-harm-related mental imagery: a content analysis study of imagery reported by young people referred to mental health services by Susi, K, Stewart, A, Knowles Bevis, R, Hawton, K

“…Self-harm exposure and the origins of self-harm-related imagery, such as the links with past self-harm and social media, as well as potential imagery-based interventions for self-harm, require further evaluation. …”

Understanding the molecular mechanism of ion and amino acid transport in neurons by Baroniņa, A

“…EAAT3 malfunction is linked to several neurological diseases and disorders, making it a therapeutic target. …”

Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study by Greggio, J, Malamateniou, C, Baruteau, KP, Reyes-Aldasoro, CC, Huckstep, OJ, Francis, JM, Williamson, W, Leeson, P, Lewandowski, AJ, Lapidaire, W

“…Conclusions: Preterm birth is linked to a distinct vascular phenotype of CoW in adults born preterm, with a higher likelihood of a CoW configuration with hypoplastic segments but a lower likelihood of absent segments. …”

Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh by Khanam, F, Rickett, NY, Ahmmed, F, Islam, MT, Mbae, CK, Im, J, Aziz, AB, Ongadi, B, Chowdhury, F, Khan, AI, Akter, A, Firoj, MG, Rahman, SIA, Haile, K, Park, SE, Mwebia, MB, Mwangi, M, Ngugi, B, Behute, MG, Kering, K, Agampodi, S, Kanungo, S, Liu, X, Pollard, AJ

“…Plasma IgG anti-Vi antibodies were measured using a standard enzyme-linked immunosorbent assay in random serosurveys of a population that had not previously received typhoid vaccination. …”

Anti-ageing properties of edible bird's nest ascertained by in vitro and in vivo studies in animal model by Hou, Zhiping

“…Hormonal imbalance during menopausal stage has been linked to increased risks of the fatal diseases including Alzheimer’s disease, dementia, stroke, diabetes mellitus, and breast cancer. …”
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Performance-based identity in a BIM environment : An architect’s perceptions and experiences by Syafizal, Shahruddin, Mohd, Zairul, Ahmad Tarmizi, Haron, Meor Mohammad, Fared

“…Consequently, architects' failing to adapt their core identity to the varying circumstances may lead to their irrelevance and being side-lined merely as aesthetic building surgeons. The current study therefore seeks a better understanding of their perceptions and experiences in manifesting their identities in the phenomenon. …”
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1 by Stubna, Michael William

“…TDMD underlies the instability of many miRNAs in diverse cell lines and animals. In this work, I probe the biological scope of TDMD as a regulatory mechanism in the nematode Caenorhabiditis elegans, which tolerates homozygous loss of the ZSWIM8 ortholog, EBAX-1, and expresses some miRNAs that are subject to rapid, developmentally regulated decay. …”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

“…We show that these ASOs can modulate T cell behavior in human cell lines and human primary cells, validating the potential of ASOs as a therapeutic approach for immune diseases. …”
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Data-driven distributionally robust CVaR portfolio optimization under a regime-switching ambiguity set by Pun, Chi Seng, Wang, Tianyu, Yan, Zhenzhen

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Financial forecasting using meta-cognitive fuzzy neural networks by Singh Akhand Pratap

“…The primary meta-cognitive strategies are Sample deletion, Sample Learning and Sample Reserve. Following on the lines of Technical Analysis carried out by traders and investors on the historical prices of a company’s stock, the project makes use of various Financial Indicators to decide whether a particular instance of time is good for investment, disinvestment or to remain idle. …”
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Taliban resurgence in Afghanistan : the role of post-conflict reconstruction by Sadia Sulaiman

“…Under the auspices of Bonn-I, the international community initiated a process of post-conflict reconstruction on both security and non-security lines. Bonn-I provided a framework for setting up an interim government tasked with drafting a constitution, convening a Loya Jirga (grand assembly), holding presidential and parliamentary elections by 2005, strengthening the Afghan police and military forces, and establishing a judicial system. …”
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Multi-spectral polarimetry imaging for early gastric cancer diagnosis by Wang, Wenfeng

“…Gastric cancer, which develops from the lining of stomach, is the fifth most severe disease worldwide. …”
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability by Zafar, Hadiqa

“…The second chapter reports the first synthesis of peptide-containing bivalent bottlebrush (co)polymers (BBPs), featuring caspase-3-cleavable peptides linked to fluorogenic probes that provide a “turnon” signal upon enzymatic cleavage. …”
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Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis by Kim, Minyoung E.

“…Given that cellular morphology is strongly linked to distinct functional states of cells, in-depth morphological analysis of such data offers immense potential for understanding their roles in brain development and disease. …”
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Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures by Cardoso da Costa, Leticia

“…A brief introduction to the current strategies utilized to impart chemical deconstruction to cross-linked polymer networks prepared by radical polymerization is presented (Chapter 4). …”
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Phonological and semantic influences on auditory word perception in children with and without reading impairments using magnetoencephalography (MEG) and electroencephalography (EEG... by Wehner, Daniel T

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新加坡和 “一带一路” ：国家与社会的视角和策略 = Singapore and the belt and road initiative : perspectives and strategies from the state and society by 范昕 Fan, Xin

“…It argues that the two key factors for Singapore’s fruitful participation in the BRI are the state’s leadership and the transnational network’s coordination. These are in turn linked with effective institutional mechanisms and smooth implementation of transnational networks. …”
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