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    A tandem-locked chemiluminescent probe for imaging of tumor-associated macrophage polarization by Huang, Jingsheng, Xu, Mengke, Cheng, Penghui, Yu, Jie, Wu, Jiayan, Pu, Kanyi

    Published 2024
    “…Through a combined molecular engineering approach via both atomic alternation and introduction of electron-withdrawing groups, near-infrared (NIR) chemiluminophores are screened out to possess record-long emission (over 800 nm), record-high CL quantum yield (2.7 % einstein/mol), and prolonged half-life (7.7 h). Based on an ideal chemiluminophore, the tandem-locked probe (DPDGN) is developed to only activate CL signal in the presence of both tumour (γ-glutamyl transpeptidase) and M1 macrophage biomarkers (nitric oxide). …”
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    Journal Article
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