Investigating the role of phosphatases in the regulation of mitosis by Leitch, I

“…</p> <p>This study also demonstrates the role of PLK1 activity in the initial recruitment of the phosphatase PP2A-B56 to kinetochores using a fluorescently labelled B56 CRISPR cell line. Additional tools for investigating the role of PLK1 in the formation of stable kinetochore-microtubule attachments are also generated and preliminary experiments carried out.…”

Chloroquine has shown high therapeutic efficacy against uncomplicated Plasmodium vivax malaria in southern Ethiopia: seven decades after its introduction by Mare, AK, Mohammed, H, Sime, H, Hailgiorgis, H, Gubae, K, Gidey, B, Haile, M, Assefa, G, Bekele, W, Auburn, S, Price, R, Parr, JB, Juliano, JJ, Tasew, G, Abay, SM, Assefa, A

“…<p><strong>Background: </strong><em>Plasmodium vivax</em> malaria is a leading cause of morbidity in Ethiopia. The first-line treatment for <em>P. vivax</em> is chloroquine (CQ) and primaquine (PQ), but there have been local reports of CQ resistance. …”

The mechanisms of sleep restriction therapy for insomnia disorder by Maurer, LF

“…While pharmacological treatment is available, the current recommended first-line intervention is a multi-component psychological therapy called cognitive behavioural therapy for insomnia (CBT-I). …”

Role of Tau and NRF2 in oxidative stress responses by Ameyaw, B

“…In the neuroblastoma cell line SH-SY5Y, which expresses high levels of Tau, Tau KO led to increased oxidative stress, reversible by re-expressing Tau, but not fully rescued by NRF2 upregulation or microtubule stabilisation.…”

Autoimmune encephalitis by Irani, SR

“…Observational studies provide the mainstay of evidence guiding first- and second-line immunotherapy administration in autoimmune encephalitis and, whereas these typically result in some clinical improvements, almost all patients have residual neuropsychiatric deficits, and many experience clinical relapses. …”

Literary metatranslation: understanding the multiple in post-communist Poland by Szymanska, K

“…In discussing the ethical ideas underpinning these works, I demonstrate how literary metatranslations and their gesture of acknowledging more than one view and line of thinking could also undermine totalised discourses and put forward a more democratic agenda.…”

Structural basis of haptoglobin-haemoglobin scavenging by CD163 by Zhou, X

“…Haptoglobin (Hp) acts as the first line of defence by scavenging Hb in the serum. Humans produce three major Hp phenotypes, the dimeric Hp 1-1 as well as the multimeric Hp 2-1 and 2-2. …”

PRMT5 controls the innate immune response by Zhang, C

“…We hypothesised that PRMT5 inhibition could increase retained introns (RIs) in the colorectal cancer cell line HCT116, leading to the production of immunogenic double-stranded RNAs (dsRNAs). …”

The bHLH transcription factor OsPRI1 activates the Setaria viridis PEPC1 promoter in rice by Carvalho, P, Gomes, C, Gonçalves, I, Lourenço, TF, Vlad, D, Langdale, JA, Saibo, NJM

“…The role of OsPRI1 <i>in planta</i> was characterized using a rice line harbouring <i>SvPEPC1_pro::GUS</i>.…”

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background by Nayak, S, Peto, TJ, Kucharski, M, Tripura, R, Callery, JJ, Quang Huy, DT, Gendrot, M, Lek, D, Nghia, HDT, van der Pluijm, RW, Dong, N, Long, LT, Vongpromek, R, Rekol, H, Hoang Chau, N, Miotto, O, Mukaka, M, Dhorda, M, von Seidlein, L, Imwong, M, Roca, X, Day, NPJ, White, NJ, Dondorp, AM

“…The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other genetic variations. …”

The unintended consequences of information system change on organizational memory: remembering and forgetting in English and Ontarian child protection services by Vogl, TM

“…Information technology change in this sector is ostensibly aimed at addressing key challenges exposed by child death reviews, performance audits, and research into child outcomes, such as the issue of past information not being available for front-line or policy decision making. However, the promise of digitization was not always achieved. …”

Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA by Kelly, DM, Jones, ESW, Barday, Z, Arruebo, S, Caskey, FJ, Damster, S, Donner, J, Jha, V, Levin, A, Nangaku, M, Saad, S, Tonelli, M, Ye, F, Okpechi, IG, Bello, AK, Johnson, DW

“…Public funding (and free at point of delivery) for medications for dialysis and kidney transplantation was available in only 24% (n = 39) and 30% (n = 50) of countries worldwide, with the proportion increasing in line with country income levels. There was reduced capacity for the management of CKD mineral bone disease in low-income countries (LICs) - serum parathyroid hormone was available in only 26% (n = 5) of LICs and the ability to administer non-calcium-based phosphate binders and cinacalcet was also very limited in LICs [16% (n = 3) and 5% (n = 1), respectively]. …”

Utilizing Social Return on Investment (SROI) as a framework for sustainable social investment: insights from flood mitigation by Dona Raihana Don Ramli, Kadaruddin Aiyub, Sarina Yusoff

“…This article explores the concept of sustainability within the framework of the triple bottom line and the Sustainable Development Goals (SDGs), specifically focusing on the Sungai Muda Flood Mitigation Program (SMFMP), Kedah involving quantitative data. …”
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Board characteristics and financial performance: evidence from Bursa Malaysia Financial Times Stock Exchange (FTSE) top 100 index firms by Nur Hafizah Abdul Puhat, Suhaily Hasnan, Khairul Ayuni Mohd Kharuddin, Hafizah Marzuki, Mazurina Mohd Ali

“…The small percentage of politically-connected directors (19%) and military-experienced directors (5%) reported in this study can be viewed favourably in line with the recent MCCG 2021 recommendation that the appointment of the directors should be apolitical or politically neutral without having any executive powers in politics. …”
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Building the semiotic meaning of critical thinking from the Prophet Ibrahim's discourses in the scene of da'wah to his father in the Qur'anic story by Mhd Ramli, Mhd Faizal, Othman, Mohd Sukki, Hajimaming, Pabiyah, Wan Sulong, Wan Muhammad

“…Although the study of critical thinking is of interest to researchers in the field of contemporary education, many people still neglect and ignore the logical and rational aspects of Prophet Ibrahim's discourses as a comprehensive scientific approach to critical thinking based on divine revelation.This has led to Muslims being accused of stagnation and backwardness due to their inability to provide evidence and produce new knowledge from the Holy Quran in line with the development of contemporary knowledge.The research adopted the descriptive analytical approach through the semiotic pragmatic method pioneered by Peirce, which consists of components namelyrepresentamen, object and interpretant, and the research relied on thecritical thinking elements by the Delphi Report, as the basis for this research. …”
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Variational model with image denoising fitting term for boundary extraction of breast ultrasound images by Badrulhisam, Nurdina, Ismail, Nurhuda, Jumaat, Abdul Kadir, Maasar, Mohd Azdi, Laham, Mohamed Faris

“…A variational model was used to extract or segment the breast ultrasound (BUS) image boundary in order to find a closed curve line of the abnormality region for further diagnosis. …”
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Learning moral values through cartoons for Malaysian preschool-aged children by Abdullah, Muhammad Alif Redzuan

“…The families&#039; explanations helped the preschoolers distinguish between good and bad moral values in line with Malay culture and Islamic teachings. The analysis was limited by the small sample size and geographical location of this study. …”
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A case study on the application of new media technology and market expansion of rural enterprises in Central China by Liu, Meng, Wan Abas, Wan Antia, Mamat, Roslina

“…In the process of brand building, this article emphasizes the combination of product characteristics and local culture to ensure that the brand image is more in line with the tastes and needs of local consumers. …”
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Development of a recombinant non-replicating Newcastle disease virus by Cheow, Pheik-Sheen, Tan, Tiong Kit, Song, Adelene Ai-Lian, Yusoff, Khatijah, Chia, Suet Lin

“…The virus retained its oncolytic activities similar to that of the replicating rAF-GFP as observed in a cell viability assay when a breast cancer cell line, MCF-7, was treated with the virus. In conclusion, this study has successfully generated a system to produce a non-replicating NDV which can be used as a viral vector for heterologous protein delivery, as a safer alternative compared to the virulent strains as an oncolytic virus. …”

Development and in vitro bioevaluation of cockle shell-calcium carbonate (Aragonite) nanoparticles for intracellular drug delivery by Isa, Tijani

“…Biocompatibilities were evaluated on macrophage cell line (J774.A1) using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 5-Bromo-2ʹ-deoxyuridine (BrdU) assays. …”
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