Surface peptide functionalization of zeolitic imidazolate framework-8 for autonomous homing and enhanced delivery of chemotherapeutic agent to lung tumor cells by Nurul Akmarina, Mohd Abdul Kamal, Emilia, Abdulmalek, Sharida, Fakurazi, Cordova, Kyle E., Mohd Basyaruddin, Abdul Rahman

“…Most importantly, this surface-functionalized nanoparticle was more selective towards lung cancer cells (A549) than normal human lung fibroblast cells (MRC-5) with a selectivity index (SI) of 3.98. This work demonstrates a new one-pot strategy for realizing a surface-functionalized zeolitic imidazolate framework that actively targets cancer cells via an autonomous homing peptide system to deliver a chemotherapeutic payload effectively.…”
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Dissolution and biological assessment of cancer-targeting nano-ZIF-8 in zebrafish embryos by Nurul Akmarina, Mohd Abdul Kamal, Emilia, Abdulmalek, Sharida, Fakurazi, Cordova, Kyle E.

“…Monitoring malformation showed minimal adverse effects with only 8.3% of edema at 62.5 μg mL–1. This study indicates that cancer-targeting GEM⊂RGD@nZIF, with its pH-responsive behavior for sustaining chemotherapeutic dissolution in a physiologically relevant environment and its non-toxicity toward the healthy embryos within the tested concentrations, has considerable potential for use in cancer treatment.…”
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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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Study of $$ {B}_c^{+}\to {\chi}_c{\pi}^{+} $$ decays by Aaij, R., Abdelmotteleb, A. S. W., Abellan Beteta, C., Abudinén, F., Ackernley, T., Adefisoye, A. A., Adeva, B., Adinolfi, M., Adlarson, P., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F.

“…A study of B c + → χ c π + $$ {B}_c^{+}\to {\chi}_c{\pi}^{+} $$ decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. …”
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State and Dynamics Estimation in an Outdoor Multi-Drone Slung Load System by Merton, Harvey

“…Real world testing shows errors of 0.2 m and 5 ◦ respectively. Applying extended Kalman filter and unscented Kalman filter formulations, simulated position estimates average around an error of 0 m, while the error noise magnitude is only 6% of the cable length at 0.06 m. …”
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Synthesis of α-methylene-δ-valerolactone and its selective polymerization from a product mixture for concurrent separation and polymer production by Khechfe, Alexander A, Eckstrom, Francesca D, Chokkapu, Eswara Rao, Baston, Lucas A, Liu, Bowei, Chen, Eugene Y-X, Román-Leshkov, Yuriy

“…MgO, CaO, and BaO supported on silica (∼5 wt%) were active for MVL production (613 K, 0.4 kPa DVL, 1.2 kPa FA, 101 kPa total pressure). …”
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Cooperation and Fairness in Multi-Agent Reinforcement Learning by Aloor, Jasmine, Nayak, Siddharth Nagar, Dolan, Sydney, Balakrishnan, Hamsa

“…For goal coverage scenarios, we find that, on average, the proposed model yields a 14% improvement in efficiency and a 5% improvement in fairness over a baseline model that is trained using random assignments. …”
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An encoding scheme capturing generic priors and properties of amino acids improves protein classification by Zhou, Xinrui, Yin, Rui, Zheng, Jie, Kwoh, Chee-Keong

“…Compared with the traditional methods using task-specific designed features, CFreeEnS improves the predicting accuracy, with an increase ranging from 5.54% to 14.14%. The results indicate that the improved CFreeEnS, free from dependence on carefully designed features, is promising in capturing generic priors and essential properties of amino acids, thereby serving as an automated feature engineering method for protein sequences.…”
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Filmwise condensation of steam on sinusoidal pin fin arrays : effects of fin height and fin pitch by Ho, Jin Yao, Leong, Kai Choong, Wong, Teck Neng

“…Our results show that the highest thermal enhancement factor (η) of 1.86 is achieved with Specimens S4 and S5 whereas Specimens S3 has the highest average heat transfer coefficient (ht). …”
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Experimental study of single- and two-phase heat transfer of fractal-like structures by Mak, Joel Tse Hoi

“…These channels were semi-circular, with a diameter ratio of 2−13, a length ratio of 0.5 and a bifurcation angle of 25˚. A multichannel parallel design consisting of four horizontal channels was used as a comparison. …”
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Africa Digest : Trends and issues in business Vol. 18 by Burger, Johan

“…This report addresses developments on the involvement of countries from the Middle East in Africa. 5. Developments for MTN, Africa’s largest telecoms company - MTN Group is Africa’s largest telecoms company. …”
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Mind the grind by Chong, Joo Xuan, Foo, Elizabeth Wei Zhi, Tan, Natasha Jing Hui, Teng, Yuxiu

“…Mind the Grind exceeded all of its impact objectives, recording improvements in attitudes (136.33%), perception of social normality (117.47%), perceived behavioural control (117.05%), actual behaviour (168.72%), and future behavioural intention (255.5%) regarding mindfulness meditation. It also attracted 169 participants to the Mastermind Challenge. …”
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Study on the impact of connected automated vehicle position on mixed traffic flow stability by Tan, Kenneth Chiao Wee

“…This is followed by creating traffic stream scenarios in which positions of CAVs and HDVs are specifically generated for 5-vehicle and 10-vehicle mixed traffic streams. …”
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Layered materials : electrochemical studies for sensing, energy applications and toxicity studies by Chia, Hui Ling

“…As such, the thesis explored the cytotoxicity profiles of various emerging classes of layered materials, namely Group 5 transition metal ditellurides and pnictogen nanosheets. …”
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Development of a 3D vehicle driving simulator (cross platform simulation of CAV) by Feng, Zhen

“…The technique has shown promise in terms of enhancing traffic flow stability, safety, and fuel efficiency. Even when only 5% of vehicles are autonomous, previous studies have shown a 40% improvement in traffic flow efficiency and up to a 28% reduction in fuel usage. …”
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1-D settlement characteristics of unsaturated soils by Li, Bing.

“…This observation was also noted by Alonso et al. (1994) 5. Compressibility increases with corresponding increase in the degree of saturation (decrease in matric suction), and vice versa. 6. …”
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Sessile droplet evaporation on patterned surfaces by Ng, Aaron Chin Liang

“…The sizes of particles in the suspension fluids increases by a factor of ten sizes from 0.05μm, 0.5μm and 6μm. The substrates used are Al2O3, TiO2 flat and a patterned micro pyramid substrate. …”
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Experimental and numerical studies on the cooling of mobile device by Setoh, Guojing.

“…Three different power levels of 3W, 4W and 5W were experimentally tested in this study. The discharging effect of the phase change material was tested in the experiments. …”
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Enhancing care quality and accessibility through digital technology-supported decentralisation of hypertension and diabetes management: a proof-of-concept study in rural Bangladesh by Xie, Wubin, Paul, Rina Rani, Goon, Ian Y., Anan, Aysha, Rahim, Aminur, Hossain, Md Mokbul, Hersch, Fred, Oldenburg, Brian, Chambers, John Campbell, Mridha, Malay Kanti

“…Participants: A total of 624 participants were enrolled in the study (mean (SD) age, 59.5 (12.0); 65.1% female). Outcomes: Changes in blood pressure and blood glucose control, patient retention and patient-visit volume at the NCD clinic and community clinics. …”
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Deposition and characterisation of a diamond/Ti/diamond multilayer structure by Mallik, Awadesh Kumar, Lloret, Fernando, Gutierrez, Marina, Rouzbahani, Rozita, Pobedinskas, Paulius, Shih, Wen-Ching, Haenen, Ken

“…The cross-sectional thickness of the titanium layer can be found to vary by as much as 0.5 µm across the length of the surface, which was caused by a subsequent hydrogen plasma etching process step of the composite film conducted after Ti sputtering. …”
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