Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Chapter 4 focuses on the site-specific glycosylation occupancy, and N- and O-glycan structures attached to virion derived SARS-CoV-2 spike glycoproteins. This glycan signature was compared to a stabilised prefusion trimeric spike, to a monomeric subunit of spike (S1) and to an antigen of a non-stabilised vaccine candidate, revealing subunit shedding of the S1 glycoprotein for the vaccine candidate. …”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. …”

Design of a dual band planar inverted-F antenna for GMS/DCS mobile handset by Fang, Jun

“…This project involved the study of size miniaturization of microstrip antenna techniques: shorting pin and shorting wall, loading, shorted spiral printed antenna and stacked shorted patch antenna are fully discussed.…”
Get full text

Study on the wear characteristics of aluminium metal matrix composite with 15% Al2O3 and 20% Al2O3 by Chua, Swu Chun.

“…The objective of this dissertation was to study the wear characteristics and behaviour of aluminium metal matrix composite materials (MMCs), namely Duralcan 286 and Duralcan 284 as a pin material when mated against three types of dics materials.…”
Get full text

Redevelopment of the continuous passive motion machine for stroke and elderly patient by Tai, Kai Jie

“…Using CPMM has also shown a clear reduction to hospital stay and recovery time. However, since the inception the CPMM in 1970, there has not been any major change to the design of the machine. …”
Get full text

Range expansion of a declining forest species, the Western Gray Squirrel (Sciurus griseus), into semi-arid woodland by Sultaire, SM, Montgomery, RA, Jackson, PJ, Millspaugh, JJ

“…Occupancy modeling revealed that western gray squirrels were equally likely to occur in piñon–juniper woodland compared to mature pine forest that they occupy elsewhere in their range. …”

Design of an exoskeleton for lifting by Lim, Ernest Zhen Xuan

“…Lower back injuries, caused by muscle strain around the lumber spine, are common in work involving manual labour. …”
Get full text

Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
Get full text

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…Results: We found significantly lower fold change in serum binding IgA responses against BA.1, BA.5 and EG.5.1 spike in the bivalent booster group, compared with the monovalent (WT) booster group, following vaccination. …”
Get full text

Towards a computer that functions like the human brain by Lee, Seow Wei

“…Spike-Timing-Dependent Plasticity and unsupervised learning in the network is researched in this report. …”
Get full text

Experimental and numerical investigations of hot-rolled stainless steel channel section columns susceptible to flexural buckling by Li, Shuai, Zhang, Lulu, Liang, Yating, Zhao, Ou

“…A thorough testing and numerical modelling programme has been conducted to investigate the minor-axis flexural buckling behaviour and resistances of pin-ended hot-rolled stainless steel channel section columns. …”
Get full text

Wearable bio-adhesive metal detector array (BioMDA) for spinal implants

“…Accordingly, herein, we report on the development and engineering of a bio-adhesive metal detector array (BioMDA), a potential wearable solution for real-time, non-invasive positional analyses of osseous implants within the spine. The electromagnetic coupling mechanism and intimate interfacial adhesion enable the precise sensing of the metallic implants position without the use of radiation. …”
Get full text

Deep learning approach to cervical segmentation from routine CT images by Duan, Yiming

“…To address the sequential and location-dependent nature of bone segmen tation information, the dissertation proposes a pre-training model for location information, and combines 2.5D image input and labeled multi-channel coding to semantically segment 3D cervical spine CT images. This method can accu rately extract the information of bone joint location of slices and incorporate it into image features in the form of channels, which can improve the accuracy of multiple bone joint segmentation and classification. …”
Get full text

Measuring membrane capacitance during a depolarizing stimulus by Chen, Peng., Gillis, Kevin., Xue, Renhao., Pui, Tze Sian.

“…It is critical to resolve the highly dynamic kinetic steps along the molecular cascade of exocytosis in order to pin down the specific actions of regulatory molecules and eventually decipher this complex and fundamental process.…”
Get full text

Wear behaviour of NiTi shape memory alloys by Yan, Lina

“…This study can provide a guideline in applications of NiTi SMAs as wear-resistant materials. For example, since mechanical properties of NiTi SMAs are close to those of cortical bones, NiTi SMA based implants such as joint replacements, bone plates, and spine fracture fixations were developed. …”
Get full text

The response of Pinus caribaea mor. var. Hondurensis seedlings to nitrogen, phosphorous and potassium fertilizers by Srivastava, P.B.L., Naruddin, Abang, Zainorin, B.Abang

“…For this purpose, seedlings were grown in plastic pots in soils collected from Bahau pine experimental area. These soils belong to Durian series and are generally poor in nutrients. …”
Get full text

Synaptic CMOS transistor by Chai, Zhen Hong

“…In this work, electrical measurements were conducted on commercial level TiN/HfO2 gated n-channel MOSFET transistor (with an equivalent oxide thickness of 1.7nm) to demonstrate that it can exhibit some critical synaptic characteristics of a biological synapse such as excitatory and inhibitory postsynaptic current (EPSC and IPSC), short-term plasticity (STP) and long-term potentiation (LTP), metaplasticity, and spike timing dependent plasticity (STDP). The mechanism behind the output characteristic of MOSFET to exhibit synaptic-like response is the charge trapping and de-trapping at defects in the oxide and oxide/semiconductor interface. …”
Get full text

A scalable variational inference approach for increased mixed-model association power by Loya, H, Kalantzis, G, Cooper, F, Palamara, PF

“…We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. …”

Indoor localization using Wi-Fi by Siswanto, Hadi

“…All models are evaluated using data collected from several reference points on block N4, North Spine, Nanyang Technological University. A simple Android application is developed to assist data collection. …”
Get full text

Development of a counter-UAV system by Tang, Wen Yue

“…Upon testing, the firing pin mechanism was found to be unable to reliably puncture the CO2 canister, even after improvements. …”
Get full text