Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Buccheri, S, James, S, Mafham, M, Landray, M, Melvin, T, Oldgren, J, Bulbulia, R, Bowman, L, Hoogervorst, LA, de Mheen, PJM, Juni, P, McCulloch, P, Fraser, AG

“…We summarize the essential principles and utility of large simple RCTs, likely applicable to all interventions but especially in order to promote their wider adoption to evaluate new medical devices.…”

Systematic assessment of COVID-19 host genetics using whole genome sequencing data by Schmidt, A, Casadei, N, Brand, F, Demidov, G, Vojgani, E, Abolhassani, A, Aldisi, R, Butler-Laporte, G, DeCOI host genetics group, Alawathurage, TM, Augustin, M, Bals, R, Bellinghausen, C, Berger, MM, Bitzer, M, Bode, C, Boos, J, Brenner, T, Cornely, OA, Eggermann, T, Erber, J, Feldt, T, Fuchsberger, C, Gagneur, J

“…We observed the presence of autosomal-recessive or likely compound heterozygous monogenic disorders in six individuals, all of which were hospitalized and significantly younger than the rest of the cohort. …”

Experimental heatwaves facilitate invasion and alter species interactions and composition in a tropical host‐parasitoid community by Chen, J, Lewis, O

“…The interactive effects of climate change and climate change-facilitated invasion have rarely been studied in multi-trophic communities, and are likely to differ depending on the nature of the climatic driver (i.e., climate extremes or constant warming). …”

Heightened interoception in adults with fibromyalgia by Todd, J, Plans, D, Lee, M, Bird, J, Morelli, D, Cunningham, A, ponzo, S, Murphy, J, Bird, G, Aspell, J

“…The FMS sample were more likely to be classified as ‘interoceptive’ on the PAT, and had significantly higher self-reported interoception compared to the pain-free sample. …”

Sleep and circadian difficulties in schizophrenia: presentations, understanding, and treatment by Freeman, D, Waite, F

“…Treatment is also very likely to lessen psychotic experiences and mood disturbances, while improving daytime functioning and quality of life. …”

Rediscovering Homo sapiens in international politics: evolution and rationality’s missing link by Johnson, D

“…An evolutionary perspective suggests: (1) rational choice is not always the most effective or efficient solution to decision-making problems; (2) cognitive biases are not mistakes, but adaptive “strategic instincts,” which evolved because they helped us make good decisions, not bad ones; (3) these “non-rational” dispositions follow a systematic pattern, allowing predictions about how people are likely to react under given conditions; (4) a theory for the origins of preferences; (5) an explanation for why humans can sometimes seem rational and sometimes non-rational (because adaptive behavior depends on context); and finally (6) error management theory suggests that cognitive biases evolved precisely because of uncertainty, as a way of minimizing costs over time. …”

Implications of human-nature interactions for livelihoods and conservation in Kasungu, Malawi by Mandoloma, L, Clark, M, Hughes, K, Coad, L, Milner-Gulland, E

“…Households near the park, women, and those of lower economic status were more likely to rely on the park for resources. Additionally, crop and livestock loss experiences were linked to higher resource collection rates. …”

Principal competency, teacher readiness, and teacher commitment in STEM education implementation: a qualitative study by Sariati Talib, Bity Salwana Alias, Mohd Effendi @ Ewan Mohd Matore

“…Findings reveal that principals with competencies in STEM knowledge, management skills, and professional attributes are more likely to boost teacher readiness and commitment. …”
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Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Subsequently, the selected research projects that were carried out in the application of genetics and genetic technologies in cancer, especially breast cancer, infectious diseases and therapeutics, including genetic immunisation will be chronicled and highlighted. It is highly likely that human genetics research through the years will become an increasingly more integral component of medical research. …”
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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior by Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Brauer, Bastian, Merino-Veliz, Nicolas, Droste, Rita, Arancibia, Felipe, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E., Bustos, Fernando J.

“…In cultured neurons, KO of VPS50 did not affect the number of synaptic vesicles but did cause mislocalization of the V-ATPase V1 domain pump and impaired synaptic activity, likely as a consequence of defects in vesicle acidification and vesicle content. …”
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Inferring electrospray emission characteristics from molecular dynamics and simulated retarding potential analysis by Schroeder, Madeleine, Gallud, Ximo, Petro, Elaine, Jia-Richards, Oliver, Lozano, Paulo C

“…We find that for these experimental data, temperatures of EMI-BF4 dimers likely range between 590 and 687 K while trimer temperatures are larger between 989 and 1092 K. …”
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Defects in β-cell Ca2+ dynamics in age-induced diabetes by Li, Luosheng, Trifunovic, Aleksandra, Köhler, Martin, Wang, Yixin, Petrovic Berglund, Jelena, Illies, Christopher, Juntti-Berggren, Lisa, Larsson, Nils-Göran, Berggren, Per-Olof

“…We show that these changes are likely to be accounted for by impaired mitochondrial function and to involve phospholipase C/inositol 1,4,5-trisphosphate–mediated Ca2+ mobilization from intracellular stores as well as decreased β-cell Ca2+ influx over the plasma membrane. …”
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Coseismic and postseismic slip of the 2005 Mw8.6 Nias‐Simeulue earthquake : spatial overlap and localized viscoelastic flow by Qiu, Qiang, Feng, Lujia, Hermawan, Iwan, Hill, Emma M.

“…We also find that the viscoelastic flow in the mantle wedge following this event was likely localized beneath the downdip region of the coseismic slip, rather than uniformly layered across the area as assumed by forward models. …”
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Soy-derived phytochemical genistein modifies chromatome topology to restrict cancer cell proliferation by Dutta, Bamaprasad, Park, Jung Eun, Qing, Ivan Toh Yi, Kon, Oi Lian, Sze, Siu Kwan

“…These data indicate that soy derivative genistein exerts complex estrogen receptor-independent effects on the epigenome likely to influence tumorigenesis by restricting cell growth.…”
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Invited perspectives : how machine learning will change flood risk and impact assessment by Wagenaar, Dennis, Curran, Alex, Balbi, Mariano, Bhardwaj, Alok, Soden, Robert, Hartato, Emir, Mestav Sarica, Gizem, Ruangpan, Laddaporn, Molinario, Giuseppe, Lallemant, David

“…Overall, machine learning is likely to drastically improve future flood risk and impact assessments, but issues such as applicability, bias and ethics must be considered carefully to avoid misuse. …”
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Effects of user behaviors on accumulation of social capital in an online social network by Rykov, Yuri, Koltsova, Olessia, Sinyavskaya, Yadviga

“…Additionally, the share of local friends, the number of received likes and the duration of SNS use are associated with social capital indicators. …”
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Pollen geochronology from the Atlantic coast of the united states during the last 500 years by Christie, Margaret A., Bernhardt, Christopher E., Parnell, Andrew C., Shaw, Timothy Adam, Khan, Nicole S., Corbett, Dorbett Reide, García-Artola, Ane, Clear, Jennifer, Walker, Jennifer S., Donnelly, Jeffrey P., Hasse, Tobias R., Horton, Benjamin P.

“…Inconsistencies were likely related to the hyperlocality of pollen chronohorizons, mixing of salt marsh sediment, reworking of pollen from nearby tidal flats, misidentification of pollen signals, and inaccuracies in or misinterpretation of other age markers. …”
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Causal attribution, benefits sharing, and earnings management by Helikum, Lukas J., Tan, Hun-Tong, Xu, Tu

“…In Experiment 1, we predict and find that managers are more likely to manage earnings when the firm's underperformance is caused by an external event and misreported earnings benefit other employees besides the reporting manager. …”
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Design of a >500MHz current starving VCO/DLL with low phase noise for digital PWM control by Chua, Dillon Yu Ze

“…However, when frequency multiplication is not needed, a DLL offers an advantage in performance over the PLL as it does not suffer on-chip noise and it has better stability. It is also less likely to accumulate jitter from power-supply and substrate noise. …”
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The impact of repeated notifications and notification checking mode on investors' reactions to managers’ strategic positive title emphasis by Chen, Wei, Tan, Hun-Tong, Wang, Elaine Ying

“…As a result, compared to a title without a strategic positive emphasis, we find that a title with a strategic positive emphasis is more likely to result in a favorable investment judgment when investors receive repeated notifications in a one-by-one mode than when they receive a notification for the first time. …”
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