Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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Food environments and obesity: a geospatial analysis of the South Asia Biobank, income and sex inequalities by Atanasova, Petya, Kusuma, Dian, Pineda, Elisa, Anjana, Ranjit Mohan, De Silva, Laksara, Hanif, Abu A. M., Hasan, Mehedi, Hossain, Md Mokbul, Indrawansa, Susantha, Jayamanne, Deepal, Jha, Sujeet, Kasturiratne, Anuradhani, Katulanda, Prasad, Khawaja, Khadija I., Kumarendran, Balachandran, Mrida, Malay K., Rajakaruna, Vindya, Chambers, John Campbell, Frost, Gary, Sassi, Franco, Miraldo, Marisa

“…Multivariate regression models were used to assess association of exposure to healthy and unhealthy food environments on waist circumference, BMI, and probability of obesity for the total sample and stratified by sex and income. Findings: The presence of a higher share of supermarkets in the neighbourhood was associated with a reduction in body size (BMI, β = - 3∙23; p < 0∙0001, and waist circumference, β = −5∙99; p = 0∙0212) and obesity (Average Marginal Effect (AME): −0∙18; p = 0∙0009). …”
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Foot care behaviours and associated factors among patients with type 2 diabetes: a cross-sectional study by Ang, Chin-Siang, Goh, Kelley Fann Ing, Lodh, Nandika, Qin, Vicky Mengqi, Liew, Huiling, Sidhu, Harvinder Raj Singh, Ng, Jun Jie, Subramaniam, Tavintharan, Tan, Elaine, Koh, Gerald Choon Huat, Best, James, Wong, Julian, Car, Josip, Ho, Andy Hau Yan, Venkataraman, Kavita

“…Additionally, more FC knowledge increased the likelihood by 20% (OR=1.21; 95% CI=1.10–1.33), and higher diabetes-related stress increased it by 1.03 times (OR=1.03; 95% CI=1.02–1.05). Conclusions: Our findings underscore the interplay of various factors influencing FC behaviours among individuals with diabetes and call for targeted interventions and tailored strategies to improve FC practices in this vulnerable population.…”
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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Concomitant with TDP-43 aggregation and proteolysis after prolonged arsenite exposure, GADD34-bound CK1ϵ catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD34−/− cells. Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1ϵ and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies.…”
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The capabilities of Multiclass Support Vector Machine (MSVM) training algorithms in grading agarwood essential oil by Anis Hazirah ‘Izzati H., Al-Hadi, Siti Mariatul Hazwa, Mohd Huzir, Nurlaila, Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The agarwood essential was graded into five grades (low, medium low, upper low, medium high, and high) and six grades (low, medium low, upper low, medium high, high, and upper high). The findings of this paper show the confusion matrix for five grades and six grades have no mismatch between actual and predicted data. …”
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Experimental and Computational Advancements in Peptidomimetic Ligand Discovery by Lee, Michael Alan

“…At the same time, discovery tools for finding peptides that modify PPIs have evolved, including advances in affinity selection techniques and combinatorial chemistry. …”
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Revealing Structural and Spin-state Dependent Reactivity of Single Atom Catalysts (SACs) with Systematically Improvable Computational Tools by Jia, Haojun (贾皓钧)

“…The ML models demonstrate superior accuracy in predicting reaction energetics compared to traditional scaling relationships. The findings validate codoping as a powerful strategy for tuning the properties of SACs to achieve enhanced ORR performance. …”
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Shifting Paradigms: Data-Centric Approach for Marine Statics Correction using Symmetric Autoencoding by Kanniah, Brindha

“…This notable precision improvement using SymAE highlights how a streamlined data-centric paradigm outperforms the traditional model-centric paradigm of marine statics correction. This finding is pivotal as it is the foundation that lays the groundwork and opens the path towards the real-world deployment of SymAE for statics correction in challenging deepwater environments.…”
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Design, fabrication and characterization of organic-inorganic hybrid solar cells by Ahmed Ali Said Ahmed

“…Moreover, the literature review provides the information about different types of lead-free solar cells and their advantages and their drawbacks. The achieved findings in this thesis include the following: (1) Six NDI-based molecules have been designed and synthesized as electron transporting layers in inverted perovskite solar cells; (2) Two pyrene-based molecules were designed and synthesized as electron transporting layers; (3) The effect of sulfur position in pyrene-based molecules was investigated (4) Three N-type conjugated polymers were explored as electron transporting layer (5) The effect of embedded sp2-nitrogen in donor and acceptors of conjugated polymer was explored and (6) Tellurium tetraiodide was explored as a promising light absorber in solar cells. …”
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Creative ageing in Singapore : a population study on participatory arts engagement and wellbeing among adults aged 50 and above by Ma, Stephanie Hilary Xinyi

“…Respondents expressed that their greatest interest lies within the genre of culture and heritage arts, with a strong preference to engage in arts activities within the community, and to attend such activities with their family or friends. Findings from propensity score matching with t-test analyses revealed that respondents who passively engaged in the arts experienced better quality of life t(728) = 3.35, p = .0008, d = .25, self-perceived health t(728) = 2.21, p = .028, d = 0.16, and sense of belonging t(728) = 2.17, p = .028, d = 0.16, as compared to those who did not. …”
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TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to mediate seed oil biosynthesis by Kong, Que, Singh, Sanjay K., Mantyla, Jenny J., Pattanaik, Sitakanta, Guo, Liang, Yuan, Ling, Benning, Christoph, Ma, Wei

“…In addition, TCP4 repressed the AtWRI1-mediated transactivation of the promoters of fatty acid biosynthetic genes. Collectively, our findings suggest that TCP4 represses fatty acid biosynthetic gene expression through interaction with AtWRI1, leading to a reduction of AtWRI1-mediated seed oil accumulation.…”
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Sensitivity study of weather research and forecasting physical schemes and evaluation of cool coating effects in Singapore by weather research and forecasting coupled with urban ca... by Zhou, Mandi, Long, Yongping, Zhang, Xiaoqin, Donthu, Eswara V. S. K. K., Ng, Bing Feng, Wan, Man Pun

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Three essays on behavioral and experimental economics by Li, Yupeng

“…We explain this difference on the basis of the Singaporean senders’ beliefs about trustworthiness: they believed that people with a Mainland Chinese accent would return more money to them than their in-group Singaporean counterparts. To bolster our findings, we confirmed in a separate experiment that the difference in response to the accents was not due to the speed of speech or vocal pitch. …”
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Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells by Kirkham, Frances, Pera, Alejandra, Simanek, Amanda M., Bano, Aalia, Morrow, George, Reus, Bernhard, Caserta, Stefano, Smith, Helen Elizabeth, Davies, Kevin A., Rajkumar, Chakravarthi, Kern, Florian

“…Given the high prevalence of CMV worldwide, our findings point to a significant global health issue. …”
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Prediction of stable perovskite quantum dots (QDs) using machine learning (ML) algorithms by Cheong, Ivan

“…Falling back to literature of known understanding of the photoluminescence property, suggested that the nanocrystal’s surface ligands interface has a substantial impact on optical properties. Hence finding a method to incorporate the string data type of synthesis methods and passivation agents to machine learning models who typically prefer numerical data types could improve the prediction abilities.…”
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Understanding lay conceptions of workplace criers: a prototype analysis by Tan, Terri Su-May

“…Moreover, they were quicker to disconfirm peripheral features as typical of workplace criers, compared to central features. These findings corroborated the prototype structure by demonstrating its impact on implicit cognition. …”
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Direct and indirect effects of fire on microbial communities in a pyrodiverse dry-sclerophyll forest by Bowd, Elle J., Egidi, Eleonora, Lindenmayer, David B., Wardle, David A., Kardol, Paul, Cary, Geoffrey J., Foster, Claire

“…Pathogenic fungi also increased in recently burnt forests that had a low fire frequency, mediated by a decline in litter carbon and an increase in soil pH in these sites. Synthesis. Our findings indicate that predicted increases in the frequency of fire may select for specific microbial communities directly and indirectly through ecological interactions, which may have functional implications for plants (increase in pathogens, decrease in symbionts), decomposition rates (declines in Actinobacteriota and Acidobacteriota) and carbon storage (decrease in ectomycorrhizal fungi). …”
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You must be myths-taken: examining belief in falsehoods during the COVID-19 health crisis by Lwin, May Oo, Sheldenkar, Anita, Tng, Pei Ling

“…However, belief in myths varied across population demographics, with ethnic minorities (Indians and Malays), females, young adults and those with lower education levels being more susceptible to myths than their counterparts (p < 0.05). Our findings suggest that current debunking efforts are insufficient to effectively counter misinformation beliefs during health crises. …”
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Application and control for virtual synchronous generators by Guo, Yian

“…Critical attributes such as the frequency-power droop characteristic, inertia response, and the generator's capability to support the grid frequency were closely examined. The findings from these simulation exercises provide compelling evidence of the VSG's value in maintaining grid stability, offering a promising solution to the challenges posed by the integration of renewable energy sources into the power grid. …”
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Surface reconstruction on spinel oxides for oxygen evolution reaction by Luo, Songzhu

“…In the end, this thesis elucidates the impact of different electrochemical conditioning methods, namely CV and chronopotentiometry (CP), on surface reconstruction and resulting OER performance of CoFe0.25Cr1.75O4. Notably, the findings differ from prior reports on Ni-based OER catalysts, highlighting that CP conditioning potentially fosters a superior degree of surface reconstruction, thereby augmenting performance. …”
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