Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by de Oliveira-Souza, AIS, Barbosa-Silva, J, Gross, DP, da Costa, BR, Ballenberger, N, Pereira, TV, Dennett, L, Armijo-Olivo, S

“…Studies should include adults (aged > 18) with neck pain who received any of the interventions of interest (education, ET, MT, and medication). The main outcome will be pain intensity. Searches will be conducted in Ovid Medline All®, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Scopus, and Cochrane Library Trials database. …”

Investigation into ion channel- and nitric oxide-mediated vasodilation in resistance arteries by Wallis, LE

“…The endothelium provides the main vasodilatory signals, including nitric oxide (NO) and endothelium-derived hyperpolarisation (EDH).…”

Tissue and spatially resolved immune drivers of fibrotic pulmonary sarcoidosis by Weeratunga, P

“…</p> <p>My studies conclude that classical monocytes and macrophages with a pro-inflammatory and pro-fibrotic gene expression profile are the main immune cells associated with fibrosis in sarcoidosis. …”

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care by Olsen, JR, Piguet, V, Gallacher, J, Francis, NA

“…</p> <p><strong>Method</strong> Data of all recorded MC and AE primary care consultations for children aged 0 to 14 years were collected and two main analyses were conducted using these data: a retrospective longitudinal analysis and an age–sex matched case-cohort analysis.…”

Effect of intra-articular corticosteroid injections for osteoarthritis on the subsequent use of pain medications: a UK CPRD cohort study by Hawley, S, Prats Uribe, A, Matharu, GS, Delmestri, A, Prieto Alhambra, D, Judge, A, Whitehouse, MR

“…Exposure of interest was single or repeated use of IACI. Main outcome measures were five-year incidence of uncombined opioids, opioidnonopioid analgesic combinations, oral corticosteroids, paracetamol, oral Non-Steroidal AntiInflammatory Drugs (NSAIDs), and topical NSAIDs. …”

Field relations, petrogenesis and emplacement of the Bhagirathi leucogranite, Garhwal Himalaya by Searle, M, Metcalfe, RP, Rex, AJ, Norry, MJ

“…</p> <p>The Bhagirathi leucogranite is situated structurally above the kyanite and sillimanite gneisses of the Vaikrita Group which, in turn, overlie the north-dipping Main Central Thrust zone of inverted metamorphic isograds. …”

Publishers’ and journals’ instructions to authors on use of generative artificial intelligence in academic and scientific publishing: bibliometric analysis by Ganjavi, C, Eppler, MB, Pekcan, A, Biedermann, B, Abreu, A, Collins, GS, Gill, IS, Cacciamani, GE

“…Publishers were identified by the total number of journals in their portfolio, and journals were identified through the Scimago journal rank using the Hirsch index (H index) as an indicator of journal productivity and impact. Main outcome measures: The primary outcomes were the content of GAI guidelines listed on the websites of the top 100 academic publishers and scientific journals, and the consistency of guidance between the publishers and their affiliated journals. …”

Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study by Chapman, JA, Wroot, E, Brown, T, Beck, LC, Embleton, ND, Berrington, JE, Stewart, CJ

“…Each NEC case was matched to a control infant based on gestation and sample DOL, the main driver of microbiome composition in this population, giving a total cohort of 16 infants for this study. …”

Trends in end digit preference for blood pressure and associations with cardiovascular outcomes in Canadian and UK primary care: a retrospective observational study by Greiver, M, Kalia, S, Voruganti, T, Aliarzadeh, B, Moineddin, R, Hinton, W, Dawes, M, Sullivan, F, Syed, S, Williams, J, De Lusignan, S

“…</p> <p><strong>Participants</strong> Adults aged 18 years or more.</p> <p><strong>Main outcome measures</strong> Mean rates of EDP and change in rates. …”

Exploiting signed TV broadcasts for automatic learning of British Sign Language by Buehler, P, Everingham, M, Zisserman, A

“…Specifically, we will address 3 main points: (i) automatic detection and tracking of the hands using a generative model of the image; (ii) automatic learning of signs from TV broadcasts of single signers, using only the supervisory information available from subtitles; and (iii) discriminative signer-independent sign recognition using automatically extracted training data from a single signer. …”

SARS-CoV-2 evolution during treatment of chronic infection by Kemp, SA, Collier, DA, Datir, RP, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, IU, Roberts, DJ, Chandra, A, Temperton, N, Sharrocks, K, Blane, E, Modis, Y, Leigh, KE, Briggs, JAG, van Gils, MJ, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK

“…In vitro, the spike double mutant bearing both ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. …”

Accelerating convolutional neural networks through enhanced designs by Gennari do Nascimento, M

“…The goal of this thesis is to provide algorithms, heuristics, and insights into accelerating CNNs.</p> <br> <p>The main method explored in this thesis is that of quantization. …”

N-methyl-D-aspartate receptor- antibody encephalitis impairs maintenance of attention to items in working memory by Dor, A, Harrison, C, Irani, SR, Al-Diwani, A, Grogan, J, Manohar, S

“…Additionally, patients reported the wrong item (misbinding errors) more than controls after congruent cues (Group x Delay [congruent condition], main effect of group, p=&lt;0.001). Our results suggest NMDARs are critical for both maintaining attention and feature binding.…”

The development of electrochemical sensors based on the use of different forms of carbon materials by Chaisiwamongkhol, K

“…<p>This thesis presents experimental work with the main aim of the development of chemical sensors using electroanalytical methods for applications in the food industry and for medical diagnosis. …”

Evaluating the cost-effectiveness of antenatal screening for major structural anomalies during the first trimester of pregnancy: a decision model by Campbell, H, Karim, J, Papageorgiou, AT, Wilson, E, Rivero-Arias, O

“…Event probabilities, costs, and outcomes for the model were informed by meta-analyses, published literature, and expert opinion.</p> <br> <p><strong>Main outcomes measures:</strong> Expected numbers of pregnancy outcomes, healthcare costs, and maternal quality adjusted life years (QALYs). …”

Multicenter double-blind study evaluating AI-driven detection of proximal deep vein thrombosis by Curry, N, Allen, E, Silsby, L, Goodacre, S, Deane, C, Deary, A, Foster, A, Griffiths, J, Sharma, R, Thomas, H, Mischewitz, S, Al-Noor, F

“…This was a two-point AI-guided compression ultrasound scan. We found that the main primary outcome was the sensitivity of AutoDVT within a diagnostic algorithm for the detection of proximal DVT by nonradiology-trained staff. …”

Synthesis and development of novel small molecule inhibitors of nucleophilic hydrolases by Gayatri

“…<p>The research described in this thesis concerns the development of novel small molecule inhibitors of biologically relevant nucleophilic hydrolases, i.e. β-lactamases, SARS-CoV-2 main protease (Mpro) and elastases, which are therapeutic targets for combatting public health threats associated with antimicrobial resistance, the COVID-19 pandemic and chronic inflammatory diseases, respectively. …”

Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders by Lek, D, Shrestha, M, Lhazeen, K, Tobgyel, T, Kandel, S, Dahal, G, Ghimire, YC, Shrestha, B, Ghimire, P, Hein, PS, Peto, TJ, Callery, JJ, Tripura, R, von Seidlein, L, Amaratunga, C, Lynch, CA, Dondorp, AM, Adhikari, B

“…A virtual meeting was convened in May 2024, followed by smaller meetings, to discuss and share experiences among regional partners, focusing on falciparum malaria elimination. Main text: The discussion among regional partners from these three countries was prompted by an isolated outbreak of falciparum malaria in April 2022 in a previously malaria-free district in Pursat province, Cambodia. …”

Effectiveness of fludrocortisone plus hydrocortisone versus hydrocortisone alone in septic shock: a systematic review and network meta-analysis of randomized controlled trials by Teja, B, Berube, M, Pereira, TV, Law, AC, Schanock, C, Pang, B, Wunsch, H, Walkey, AJ, Bosch, NA

“…<p><strong> Measurements and Main Results: </strong></p> Among 7,553 references, we included 17 trials (7,688 patients). …”

Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial by Relton, C, Blake, MK, Bridge, G, Umney, D, Taylor, SJC, Adams, J, Mihaylova, B, Griffiths, C, Hooper, R, Phillips, R, Palmer, L, Gamston, A, Williamson, K

“…Results: The household survey response rate was below the 50% target for progression to the main trial. Most local fruit and vegetable vendors accepted vouchers. …”