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    2H-azirines as potential bifunctional chemical linkers of cysteine residues in bioconjugate technology by Chen, Yang, Yang, Wenjie, Wu, Jiamin, Sun, Wangbin, Loh, Teck-Peng, Jiang, Yaojia

    Published 2022
    “…The cleavage of a C-N double bond of 2H-azirine furnishes an amino amide functional group in situ through a thiol addition and ring-opening process. It works with a broad scope of thiols and 2H-azirines in the absence of any catalysts at room temperature. …”
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    Journal Article