Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer by McCuaig, S

“…Using a panel of CRC cell lines and primary human organoids, we confirmed that this prognostic association is due to a functional interaction between IL-22 and mutant KRAS by observing that IL-22 enhances chemoresistance, 3-dimensional clonogenicity, and proliferation specifically in CRC cells with both high IL-22 receptor levels and <em>KRAS</em> mutations. …”

Citizenship and the politics of poverty definition during the segregation, apartheid and democratic eras in South Africa: 1910-2010 by Magasela, W

“…The Household Subsistence Level (HSL) and the Minimum Living Level (MLL) were derivatives of the PDL (the HSL was exactly the PDL, the MLL was lower in value) and were conceptually similar were used as poverty definitions and poverty lines to fix the wages of black workers, thus showing the link between the denial of citizenship and the politics of poverty definition.…”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…Applying FlowScore to data from the COMPARE study revealed a positive association with the time-delay from sample collection to measurement, which was verified experimentally. The LifeLines dataset revealed age, sex, and smoking among factors affecting FlowScore. …”

Dress, Feminism, and British New Woman Novels by Allen-Johnstone, C

“…For example, Grand elevated cross-class feminism, but she belittled middle-class women's taste, side-lined poor women’s most pressing sartorial concerns, and dressed to impress. …”

The biggest challenges resulting from the COVID-19 pandemic on gender-related work from home in biomedical fields—world-wide qualitative survey analysis by Bezak, Eva, Carson-Chahhoud, Kristin V., Marcu, Loredana G., Stoeva, Magdalena, Lhotska, Lenka, Barabino, Gilda A., Ibrahim, Fatimah, Kaldoudi, Eleni, Lim, Sierin, Da Silva, Ana Maria Marques, Tan, Peck Ha, Tsapaki, Virginia, Frize, Monique

“…Participants reported increased domestic duties, blurred lines between home and work, and long workdays. Finding adequate workspace was a problem, and adaptations were necessary, especially when adults shared the same setting for working and childcare. …”
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Exploring the trait plasticity of ipa1-2d and qpl6 under different nitrogen treatments and heading periods by Zhuang, Wenshu, Jin, Guangyang, Zou, Yiting, Bian, Zhong, Xie, Dong, Zhang, Shuwei, Yeilaghi, Hadi, Yu, Liangliang, Wong, Muiyun, Fan, Xiaolei, Zhao, Dongsheng, Liu, Qiaoquan, Zhang, Lin

“…QTL analysis could elaborate on the environmental impact on trait plasticity using nearly isogenic lines (NILs) of different QTLs. Two QTLs, ipa1-2D and qPL6 are identified to have pleio-tropic contributions to panicle size and plant architecture, but their responses to different growth conditions are still unclear. …”
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Performance-based identity in a BIM environment : An architect’s perceptions and experiences by Syafizal, Shahruddin, Mohd, Zairul, Ahmad Tarmizi, Haron, Meor Mohammad, Fared

“…Consequently, architects' failing to adapt their core identity to the varying circumstances may lead to their irrelevance and being side-lined merely as aesthetic building surgeons. The current study therefore seeks a better understanding of their perceptions and experiences in manifesting their identities in the phenomenon. …”
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Tablets, Pens, and Pencils: The Influence of Tools on Sketching in Early Stage Design by Das, Madhurima, Huang, May, Yang, Maria C

“…We hypothesize that participants using tablet and pencil will produce fewer drawings than those using pen due to their ability to erase and focus on perfecting drawings, and we expect participants using the tablet to produce cleaner drawings with smoother strokes due to the tablet’s ability to auto-smooth lines. Based on prior literature, we posit that women and gender minorities will produce fewer sketches and use the feathering style of sketching more than men.…”
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1 by Stubna, Michael William

“…TDMD underlies the instability of many miRNAs in diverse cell lines and animals. In this work, I probe the biological scope of TDMD as a regulatory mechanism in the nematode Caenorhabiditis elegans, which tolerates homozygous loss of the ZSWIM8 ortholog, EBAX-1, and expresses some miRNAs that are subject to rapid, developmentally regulated decay. …”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

“…We show that these ASOs can modulate T cell behavior in human cell lines and human primary cells, validating the potential of ASOs as a therapeutic approach for immune diseases. …”
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Data-driven distributionally robust CVaR portfolio optimization under a regime-switching ambiguity set by Pun, Chi Seng, Wang, Tianyu, Yan, Zhenzhen

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Financial forecasting using meta-cognitive fuzzy neural networks by Singh Akhand Pratap

“…The primary meta-cognitive strategies are Sample deletion, Sample Learning and Sample Reserve. Following on the lines of Technical Analysis carried out by traders and investors on the historical prices of a company’s stock, the project makes use of various Financial Indicators to decide whether a particular instance of time is good for investment, disinvestment or to remain idle. …”
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Taliban resurgence in Afghanistan : the role of post-conflict reconstruction by Sadia Sulaiman

“…Under the auspices of Bonn-I, the international community initiated a process of post-conflict reconstruction on both security and non-security lines. Bonn-I provided a framework for setting up an interim government tasked with drafting a constitution, convening a Loya Jirga (grand assembly), holding presidential and parliamentary elections by 2005, strengthening the Afghan police and military forces, and establishing a judicial system. …”
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Multi-spectral polarimetry imaging for early gastric cancer diagnosis by Wang, Wenfeng

“…Gastric cancer, which develops from the lining of stomach, is the fifth most severe disease worldwide. …”
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase by Attwood, M

“…The transcriptional regulator, Thanatos associated protein 11 (THAP11) was identified as a novel high stoichiometry OGFOD1-interacting protein across a range of cell lines. Analysis of the THAP11 transcriptional programme in SW620 cells defined a repressive action of OGFOD1 overexpression on THAP11 DNA binding and target gene expression. …”

The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Towards depth-resolved multi-cubic-centimeter field of view endoscopic camera for intraoperative nerve identification. by Yoon, Yong-Chul

“…In the second component of this thesis, we provide extensive theoretical and experimental studies on how optical amplifiers can be used in OCT to address sensitivity challenges of high-speed surgical OCT platforms like CL-OCT. Together, these lines of research define a new approach to meeting the need for OCT-based solutions for intraoperative nerve identification. …”
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P2P energy trading among isolated microgrids in the remote area by Huang, Rui

“…As for the power supply in remote areas, the traditional transmission method by using the central grid has the drawbacks of large transmission loss and long transmission lines, which are easy to be broken. At the same time, there are areas where electricity is not available because of costly transmission losses, for the transmission networks are not yet widespread. …”
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Induction of apoptosis and the signalling pathways involved by dillenia suffruticosa dichloromethane root extract in mcf-7 and mda-mb-231 breast cancer cells by Foo, Jhi Biau

“…DCMDS induced apoptosis and oxidative stress in these two cell lines. Treatment with α- tocopherol reduced the cytotoxicity of DCM-DS at 50 µg/mL in the cells, suggesting that DCM-DS induced lipid peroxidation to destroy the cancer cells. …”
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Biogenic amines and urocanic acid in keropok lekor, and their effects on cytotoxicity and proinflammatory mediator secretion of macrophage cell culture by Hussain, Husniza

“…Future research on in vitro cytotoxicity effects of BAs in fishery products or other foods using different cell lines to resemble in vivo study is warranted.…”
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