Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…Sulfur–arene interactions appear to tune the reactivity of methionine residues in a manner consistent with rates of oxidation. These findings highlight an underappreciated role for methionine—to protect catalytic histidine residues—and indicate a means by which ptRNases remain functional in oxidatively challenging physiological environments. …”
Get full text
Get full text

Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…This is the first study to examine the relationship between the multi-dimensional filial piety and the work-family interface among working caregivers of the elderly, with considerations of relationship quality and gender. Findings point to potential directions for future research and offer suggestions on how to aid working caregivers to optimize interactions between work and family domains. …”
Get full text

Metal-organic architectures driven by a multifunctional 6-aminouracil spacer : structures, noncovalent interactions, and conductivity by Purkayastha, Atanu, Dhar, Sourab, Mondal, Suvra Prakash, Franconetti, Antonio, Frontera, Antonio, Ganguly, Rakesh, Kirillov, Alexander M., Misra, Tarun Kumar

“…The computational study for molecular electrostatic potential (MEP) surface energies revealed an important finding, namely a decrease of the π-acidity of the uracil ring upon coordination and a consequent increase of the π-basicity of the phenyl-sulfonate ring, resulting in effective anti-parallel π–π stacking interactions in 1 and 2. …”
Get full text

Preliminary environmental risk consideration for small UAV ground risk mapping by Chung, Han Jie, Mohd Hasrizam Che Man, Sivakumar, Anush Kumar, Low, Kin Huat

“…The regions with high rainfall, increased bird population per site and strong signal interference can be extracted.These high-risk locations can be expected to be more hazardous for sUAVs to fly in. Findings for environmental risk-tiering and risk-mapping are preliminary and based on the available environmental data as identified in this study. …”
Get full text

Growth and physical properties of organic semiconducting single crystals by Tan, Ke Jie

“…Therefore, experimental studies aids in finding parameters responsible for the physical properties of materials. …”
Get full text

New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Additionally, expansion of the phytochemical-antibiotic interaction profiles were also carried out with various classes of antibiotics and phytochemicals to understand the interaction patterns by establishing a novel interaction network that provides a baseline to identify the mechanism of action of the phytochemicals and molecular mechanism of synergy. The above findings have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals). …”
Get full text

Improved life cycle assessment for desalination : handling the choices and uncertainties by Zhou, Jin

“…The system boundary and characterization approach was selected based on our previous findings. This work provided the environment profile of Singapore’s desalinations with improved reliability. …”
Get full text

Occurrence, human exposure and dynamics of phthalates in ACMV indoor environments : method development and field studies by Chen, Ailu

“…The increases are because of either resuspension of phthalates bound to settled dust or partitioning of gas-phase phthalates to the airborne particles. The findings also demonstrate that the gas fractions of the low-volatile phthalates decrease when the airborne particle concentrations increase.…”
Get full text

先秦思想中音乐与情感的关系 ：以《孟子》《庄子》“乐”（lè）与 “乐” （yuè）的运用为核心 = The relations between music and emotion in Pre-Qin thought : an analysis of the usage of ‘Lè’ and ‘Yuè’ in the Mencius and the Zh... by 何昱慧 Ho, Adeline Yu Hui

“…Understanding the relations between“乐” and Music and Emotions in Pre-Qin text are necessary in finding the underlying significance. On the other hand, it also helps in the analysis of ideology promoted to shape the society at that point of time, which is beneficial to the progress of research in the topic.…”
Get full text

新加坡当代社会同志自由的研究 = A study of homosexuals’ liberty in present day Singapore by 陈惠嫔 Tan, Mabel Hui Ping

“…Analysis of credible survey results and reports, as well as gathering personal anecdotes and surveys from respondents was done. Findings were analyzed in an attempt to understand and explain how the tension between the individuals and society at large works. …”
Get full text

Aircraft noise, overheating and poor air quality in London primary schools' classrooms by Montazami, Azadeh

“…It is shown in this study that overheating and air quality benchmarks which are proposed by 'Department for Education and Skills' in Building Bulletin 101 and used to design and refurbish the UK schools, are relaxed benchmarks in comparison with the others which are proposed by different organisations and researchers. The overall findings of this thesis have been developed to draw the attention of school designers' to the current and future potential conflicts between the comfort factors in schools' classrooms. …”
Get full text

Neuronal control of cardiac excitability in pro-hypertensive states by Larsen, H

“…</p> <p><b>Chapter 7</b> forms the concluding discussion that summarises the main findings of this thesis and attempt to place it in a clinical context, and highlights avenues of further research. …”

Outcomes of shoulder replacement surgery in routine care by Craig, RS

“…The available studies were of low quality and produced few reliable findings to inform practice. RCTs provided very little useful data on the rates of revision surgery and adverse events. …”

Sexual violence at higher education institutions: prevalence, nature, and opportunities for prevention by Steele, B

“…I also encountered significant political sensitivities with regard to reporting the findings to relevant stakeholders, potentially threatening the ability of internal researchers to carry out such research, as suggested by Universities UK. …”

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Steinmetz, JD, Seeher, KM, Schiess, N, Bennett, DA, Maude, RJ, Newton, CRJ, Rodriguez, JAB

“…A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. <p><b>Findings</b></p> Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. …”

Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…</p> <br> <p><strong>Findings:</strong> We sequenced 731 genomes from isolates obtained during surveillance across the three sites between Oct 1, 2016, and Aug 31, 2019 (24 months in Dhaka and Kathmandu and 34 months in Blantyre). …”

Development and characterization of collagen type I and hyaluronic acid (HA) based interlaced scaffolds for tissue engineered heart valves (TEHVS) by Nazir, R

“…While evaluated against the criterion for tissue engineered heart valve (TEHV), S-3 and S-4 among interlaced scaffolds/compositions not only matched mechanically but also showed high degradation resistance which potentially made them as '<b>close-fit</b>' candidates. Findings from this thesis indicated that collagen/HA interlaced scaffolds have the potential to fill in the niche for designing an ideal TEHV. …”

The influence of pregnancy complications on fetal and neonatal cardiovascular development by Aye, C

“…As up to 8% of pregnancies are affected by hypertensive disorders of pregnancy and approximately 10% of all births are preterm, understanding the mechanisms behind these findings and their relevance to long term cardiovascular disease in this population is of great public health interest. …”

Relationship of sperm protamine content with bull breeding soundness evaluation and sperm DNA damage by Mohamed Abbad Alfadel, Fatima

“…Post hoc pairwise comparison showed an increased DNA damage in bulls with lower protamine values. The findings of this study concluded that sperm protamine can be used as a useful biomarker to predict semen quality and male potential fertility. …”
Get full text

Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…From the haematological finding, the total white blood cell (WBC) count in the cancer group was high. …”
Get full text