Transcriptional regulation of type I interferon responses of myeloid antigen presenting cells by Sin, Wei Xiang

“…Macrophages, as crucial mediators of an innate immune response, exhibit functional plasticity by playing an essential role in both the initiation and resolution of inflammation. …”
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Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis by Sonesson, Andreas, Przybyszewska, Kornelia, Eriksson, Sigrid, Mörgelin, Matthias, Kjellström, Sven, Davies, Julia, Potempa, Jan, Schmidtchen, Artur

“…Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacterial colonization and infection. …”
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Mendelian randomization identifies proteins involved in neurodegenerative diseases by Belbasis, L, Morris, S, Van Duijn, C, Bennett, D, Walters, R

“…The newly-associated proteins indicated the involvement of complement (C1S, C1R), microglia (SIRPA, SIGLEC9, PRSS8) and lysosomes (CLN5) in AD, interleukin-6 pathway (CTF1) in PD, lysosomes (TPP1), blood–brain barrier integrity (MFAP2) and astrocytes (TNFSF13) in ALS, and blood–brain barrier integrity (VEGFB), oligodendrocytes (PARP1), node of Ranvier and dorsal root ganglion (NCS1, FLRT3, CDH15), and innate immune system (CR1, AHSG, WARS) in MS. Our study demonstrates how harnessing large-scale genomic and proteomic data can yield novel insights into the role of plasma proteome in the pathogenesis of neurodegenerative diseases.…”

Evolutionary explanations and the debunking of moral beliefs by Cofnas, N

“…According to the debunkers, natural selection does not track mind-independent moral truth, so the discovery that our moral beliefs (realistically construed) were caused by natural selection renders them unjustified. I argue that our innate moral faculty is likely not the product of natural selection, but rather social selection. …”

Metformin alters human host responses to Mycobacterium tuberculosis in healthy subjects by Lachmandas, Ekta, Eckold, Clare, Böhme, Julia, Koeken, Valerie A. C. M., Mardiana Marzuki, Blok, Bastiaan, Arts, Rob J. W., Chen, Jinmiao, Teng, Karen W. W., Ratter, Jacqueline, Smolders, Elise J., Van den Heuvel, Corina, Stienstra, Rinke, Dockrell, Hazel M., Newell, Evan, Netea, Mihai G., Singhal, Amit, Cliff, Jacqueline M., Van Crevel, Reinout

“…Conclusion: Metformin has a range of potentially beneficial effects on cellular metabolism, immune function, and gene transcription involved in innate host responses to M. tuberculosis.…”
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ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition by Ly, Phuong Thao, Xu, Shaohai, Wirawan, Melissa, Luo, Dahai, Roca, Xavier

“…Transcriptomic analysis of ZAP-isoform-specific knockout cells revealed uncharacterized host mRNAs targeted by ZAPL/S with broad cellular functions such as unfolded protein response (UPR), epithelial-mesenchymal transition (EMT), and innate immunity. We established that endogenous ZAPL and ZAPS localize to membrane compartments and cytosol, respectively, and that the differential localization correlates with their target-RNA specificity. …”
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Viral proteases activate the CARD8 inflammasome in the human cardiovascular system by Nadkarni, Rhea, Chu, Wern Cui, Lee, Cheryl Q. E., Mohamud, Yasir, Yap, Lynn, Toh, Gee Ann, Beh, Sheryl, Lim, Radiance, Fan, Michelle Yiyun, Zhang, Lyanne Yizhuo, Robinson, Kim, Tryggvason, Karl, Luo, Honglin, Zhong, Franklin, Ho, Lena

“…Nucleotide-binding oligomerization domain (NBD), leucine-rich repeat (LRR) containing protein family (NLRs) are intracellular pattern recognition receptors that mediate innate immunity against infections. The endothelium is the first line of defense against blood-borne pathogens, but it is unclear which NLRs control endothelial cell (EC) intrinsic immunity. …”
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Induction of z-conformation in ribosomal RNA by Z-DNA binding domain Zα of the human double-stranded RNA deaminase I (ADAR1) by Zhao, Jing

“…The Z-DNA/Z-RNA binding domain Zα of the human RNA editing enzyme double-stranded RNA deaminase I (ADAR1) is found to influence various biological functions, such as the DNA-mediated innate immune response, and transcriptional modulation of gene expression. …”
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Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection by Spatola, M, Nziza, N, Irvine, EB, Cizmeci, D, Jung, W, Van, LH, Nhat, LTH, Ha, VTN, Phu, NH, Nghia, HDT, Thwaites, GE, Lauffenburger, DA, Fortune, S, Thuong, NTT, Alter, G

“…Antibody studies included analysis of immunoglobulin isotypes (IgG, IgM, IgA) and subclass levels (IgG1–4) and the capacity of <i>M. tuberculosis</i>-specific antibodies to bind to Fc receptors or C1q and to activate innate immune effector functions (complement and natural killer cell activation; monocyte or neutrophil phagocytosis). …”

Metagenetic analysis of gut microbial community of Malaysian mahseer Tor tambroides (Bleeker, 1854) (Cyprinidae) and its probiotics potential by Tan, Chun Keat

“…Bacillus sp. could enhance the innate immune system of fishes by increase lysozyme activity in blood serum. …”
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The impact of death and dying on the personhood of medical students : a systematic scoping review by Ho, Chong Yao, Kow, Cheryl Shumin, Chia, Joshua Chin Howe, Low, Jia Ying, Lai, Melvin Yong Hao, Lauw, Sarah-Kei, How, Ashley Ern Hui, Tan, Lorraine Hui En, Ngiam, Lisa Xin Ling, Chan, Natalie Pei Xin, Kuek, Joshua Tze Yin, Nur Haidah Ahmad Kamal, Chia, Jeng Long, Ahmad Hanifah Marican Abdurrahman, Chiam, Min, Ong, Yun Ting, Chin, Annelissa Mien Chew, Toh, Ying Pin, Mason, Stephen, Krishna, Lalit Kumar Radha

“…The Split Approach revealed similar themes and categories that correspond to the Innate, Individual, Relational and Societal domains in the Ring Theory of Personhood. …”
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Effects of thrombin and its related peptide fragments on neutrophils by Lim, Chun Hwee

“…In addition, these peptides were shown to have immunomodulatory effects on monocytes, but whether they have any effects on the other major innate immune cells, neutrophils, was not known. Hence, we aimed to address the immunomodulatory potential of these C-terminal truncations on neutrophil functions. …”
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Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…Combined correlation and pathway analysis (ingenuity) of the CSF protein pattern associated with TNF expression (encompassing elevated levels of BAFF, IFN-γ, IL-1β, IL-10, IL-8, IL-16, CCL21, haptoglobin and fibrinogen) showed a particular relationship to the interaction between innate and adaptive immune response. The CSF sTNF-R1-associated pattern (encompassing high levels of CXCL13, TWEAK, LIGHT, IL-35, osteopontin, pentraxin-3, sCD163 and chitinase-3-L1) was mainly related to altered T cell and B cell signalling. …”
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Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)1-7. …”
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Conservation of red blood cell signalling in Plasmodium merozoite invasion by Yong, James Jia Ming

“…It is though clear that the parasite has exploited innate RBC signalling cascades to direct invasion. …”
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Aqueous-only exfoliation of pristine graphite to graphene : towards sustainable, multifunctional polymer nanocomposites by Seyed Ismail Seyed Shahabadi

“…In addition to being the polymer matrix and stabilizer, WPU endowed the sensors with shape conformality too, which significantly increased the real-life sensitivity of the sensors in monitoring biomechanical deformations and reproducing blood-pressure waveforms. This innate shape-conformality obviated the need for an additional skin-conformal layer. …”
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Self-healing materials for flexible electronic devices by Tiwari, Naveen

“…However, they still suffer from innate problems like mechanical rupture, scratching and bending torsion because of their “soft” and flexible nature related to their solid counterparts. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…TRIM21, TRIM26, IRF2, and SAMHD1) might support the replication of IAV through suppression of the innate and adaptive antiviral immune responses. The other up-regulated IHFs could also enhance the replication of IAV at different stages of the virus lifecycle: endocytosis (BTC), prevention of apoptosis (TIMM17A), nuclear import (JAK2), and translation elongation of viral proteins (HEXIM1). …”
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Swallow me (Again) by Qin, Ai Xin

“…The artwork presents a speculative emancipation ritual questioning the ideology of healing and its possibility in the context of something so innately present.   Perhaps the only way to end a cycle of trauma is to remove its latest vessel from the world.…”
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