Exploring the induction of preproinsulin-specific Foxp3+ CD4+ Treg cells that inhibit CD8+ T cell-mediated autoimmune diabetes by DNA vaccination by Stifter, Katja, Schuster, Cornelia, Schlosser, Michael, Boehm, Bernhard Otto, Schirmbeck, Reinhold

“…TGF-β expression was significantly enhanced in the Foxp3(+) CD25(+) Treg cell population of vaccinated/ppins-primed mice. Ablation of Treg cells in vaccinated/ppins-primed mice by anti-CD25 antibody treatment abolished the protective effect of the vaccine and enabled diabetes induction by pCI/ppins. …”
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Reverse translational approaches to population neuroimaging: using rodent models to interpret genetic associations with MRI by Tisca, C

“…The genetic similarity between humans and mice means we can measure and compare equivalent phenotypes across species. …”

Dysfunctional cardiac energy transduction, mitochondrial oxidative stress, oncogenic and apoptotic signaling in DiNP-induced asthma in murine model by Kehinde, Samuel Abiodun, Olajide, Abosede Temitope, Fatokun, Tolulope Peter, Faroud, Dalia, Hadi, Najah R., Elgazzar, Ahmed M., James, Adewale Segun, Ashour, Mohamed H. Mazhar

“…In the current study, we assessed the crosstalk between DiNP-induced asthma and cardiac cellular respiration, oxidative stress, apoptotic potential, and induction of oncogenic factors. Ten male BALB/c mice with a weight range of 20–30 g were divided into two groups, each comprising five mice. …”
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The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator by Wong, Brandon Han Siang, Shim, Heesung, Goay, Stephanie Shee Min, Ong, Seow Theng, Nur Ayuni Binte Muhammad Taib, Chai, Kelila Xin Ye, Lim, Kerry, Huang, Dachuan, Ong, Choon Kiat, Vaiyapuri, Thamil Selvan, Cheah, Yeong Cheng, Wang, Yulan, Wulff, Heike, Webster, Richard David, Shelat, Vishalkumar G., Verma, Navin Kumar

“…SKA-346 (30 mg kg-1), tolerated by mice after intra-peritoneal administration, exhibited a peak plasma concentration of 6.29 μg mL-1 (29.2 μM) at 15 min and a circulating half-life (t 1/2) of 2.8 h. …”
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Determination of the life span of inflammatory dendritic cells by Tay, Yong Long

“…Due to the lack of a proper Plet-1 knockout mice model previously, cell ablation study of Plet-1+ DCs was not possible. …”
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Experimental studies of melting PCM in a heat sink by Muhammad Azrin Sa'ad.

“…The heat sink design that was the focus of this study is based on the pin finned heat sink design. Experiments mainly pertaining to the characteristics of the melting PCM in the heat sinks were observed and recorded to further understand the behaviours and characteristics of the melting PCM. …”
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Songs of The Runaway Heart / by Marisa Fendi, author 655832

“…Despite their fathers’ bond over wealth and luxuries, Kamelia and Haikal’s bond was made up of glares and stolen ice pops. But one day, everything stopped. The banter, the bag-tugging, the eye-rolling. …”

Stability of unsaturated soil slopes covered with melastoma malabathricum in Singapore by Satyanaga, Alfrendo, Rahardjo, Harianto

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Predicting response of reinforced concrete slabs under low-velocity impact by Xiao, Yao, Li, Bing, Fujikake, Kazunori

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Mathematical modelling of subglacial drainage and erosion by Ng, FSL

“…The classical theory of channelized subglacial drainage,due orginally to Röthlisberger (1972) and Nye (1976), considers water flow in an ice channel overlying a rigid, impermeable bed. …”

Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

“…Finally, treatment with another PPARβ/δ agonist increased VLDLR levels in the liver of wild-type mice, but not PPARβ/δ-deficient mice, confirming the regulation of hepatic VLDLR by this nuclear receptor. …”
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Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

“…Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. …”

Investigation of the effects of Anti-Müllerian Hormone on preventing Doxorubicin-induced primordial follicle loss by Wei, X

“…Follicular damage caused by DXR was also demonstrated in adult mouse ovaries in vivo but not in human pre-pubertal ovarian tissue xenotransplanted into mice. Although there were trends, there was no significant effect of AMH treatment alone on inhibiting primordial follicle activation in mouse ovarian tissue (in vitro and in vivo) or human ovarian tissue (xenotransplanted into mice). …”

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. Results The PPARβ/δ agonist GW501516 prevented lipid-induced ER stress in mouse and human myotubes and in skeletal muscle of mice fed a high-fat diet. …”
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Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…Notably, when the IB-treated mice were subsequently re-challenged with CT26 cells, the immune mediated-response prevented the establishment of a second tumor in the mice. …”
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Hybrid biometric authentication for automatic teller machine by Arokiasamy, Steven R., Tomal, Md Raihanul Islam, Moorthy, Kohbalan, Mohd Daud, Kauthar

“…Unlike traditional password or PIN-based methods, biometric authentication uses unique physical characteristics, such as fingerprints, to verify identity. …”
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An Integrated Vehicle, Payload, and Trajectory Optimization Framework for Highly-Coupled Aircraft Systems by Dewald, Annick J.

“…The science mission objective of these case studies is to reduce uncertainty in predictions of sea-level rise by understanding ice mechanics that drive ice shelf collapse and destabilize previously grounded glaciers.…”
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Numerical study of earth pressures on rigid pipes with tire-derived aggregate inclusions by Ni, Pengpeng, Qin, X., Yi, Yaolin

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Raman spectroscopic study of the effects of dissolved NaCl and temperature on water structure by Wang, Yanan.

“…Water ice exhibited anomalies when under cooling, compressing and clustering excitation. …”
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A study on the impacts caused by developments in the arctic region by Yeo, Melisa Hui Mei

“…With retreating Arctic sea ice extent and the longer ice-free periods, opportunities are created for the maritime industry. …”
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