Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains by Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer-van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, Matthews, Paul M.

“…To delineate the pathological correlations of distinct lipid species, we conducted a comprehensive characterization of both spatially localized and global differences in brain lipid composition in AppNL-G-F mice with spatial and bulk mass spectrometry lipidomic profiling, using human amyloid-expressing (h-Aβ) and WT mouse brains controls. …”
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Enhanced restoration of visual code after targeting ON bipolar cells compared to retinal ganglion cells with optogenetic therapy by Rogers, J, Hughes, S, Ebrahimi, A, Allen, A, Storchi, R, Lindner, M, Peirson, S, Badea, T, Hankins, M, Lucas, R

“…Our data show that, while both approaches restore visual responses with impressive fidelity, ON BC targeting produces a richer visual code closer to that of wild-type mice. …”

Strong immune responses and robust protection following a novel protein in adjuvant tuberculosis vaccine candidate by Korompis, M, De Voss, CJ, Li, S, Richard, A, Almujri, SS, Ateere, A, Frank, G, Lemoine, C, McShane, H, Stylianou, E

“…Vaccinated mice had enriched lung parenchymal antigen-specific CD4 + CXCR3 + KLRG1− T cells previously associated with TB protection. …”

Lessons from a retrospective look at India’s upstream sector by Elango, P

Cloud detection and classification with artificial intelligence for satellite optical image by Yao, Yuhan

“…It sounds easy but practically very challenging to detect clouds accurately without confusing the detection with white ground, including areas covered snow or ice. This project is to study and test innovative approaches for accurate detection and classification of clouds by applying machine intelligence and big data. …”
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Russia’s Arctic offshore opportunities by Loe, JSP

“…However, only a large oil discovery will be sufficient to justify the costs of development and of necessary infrastructure in the harsh weather conditions of the ice-covered Kara Sea. There is also potential for Arctic petroleum development in the previously disputed area between Norway and Russia, in the Barents Sea; this could contribute to the fulfilment of Russia’s Arctic offshore ambitions.…”

Planned Geological Investigations of the Europa Clipper Mission by Daubar, I. J., Hayes, A. G., Collins, G. C., Craft, K. L., Rathbun, J. A., Spencer, J. R., Wyrick, D. Y., Bland, M. T., Davies, A. G., Ernst, C. M., Howell, S. M., Leonard, E. J., McEwen, A. S., Moore, J. M., Phillips, C. B., Prockter, L. M., Quick, L. C., Scully, J. E. C., Soderblom, J. M., Brooks, S. M., Cable, M., Cameron, M. E., Chan, K., Chivers, C. J., Choukroun, M., Cochrane, C. J., Diniega, S., Dombard, A. J., Elder, C. M., Gerekos, C., Glein, C., Greathouse, T. K., Grima, C., Gudipati, M. S., Hand, K. P., Hansen, C., Hayne, P., Hedman, M., Hughson, K., Jia, X., Lawrence, J., Meyer, H. M., Miller, K., Parekh, R., Patterson, G. W., Persaud, D. M., Piqueux, S., Retherford, K. D., Scanlan, K. M., Schenk, P., Schmidt, B., Schroeder, D., Steinbrügge, G., Stern, A., Tobie, G., Withers, P., Young, D. A., Buratti, B., Korth, H., Senske, D., Pappalardo, R.

“…Europa’s fascinating collection of ice-focused geology provides an unparalleled opportunity to investigate the dynamics of icy shells, ice-ocean exchange processes, and global-scale tectonic and tidal stresses. …”
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Environmental contamination in a coronavirus disease 2019 (COVID-19) intensive care unit—what is the risk? by Ong, Sean Wei Xiang, Lee, Pei Hua, Tan, Yian Kim, Ling, Li Min, Ho, Benjamin Choon Heng, Ng, Ching Ging, Wang, Dong Ling, Tan, Boon Huan, Leo, Yee Sin, Ng, Oon Tek, Wong, Michelle Su Yen, Marimuthu, Kalisvar

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Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. …”
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中朝古代桃花源文学比较研究 = A comparative study of peach blossom literature in ancient China and Korea by 蔡佳敏 Cai, Jiamin

“…This peach blossom imagery develops from Tao Yuan Ming's portrayal of a peach blossom in his famous poetry "The Peach Colony" ("Tao Hua Yuan Shi with Ji"). …”
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UMPSA receives a courtesy visit from the Director of Civil Defence Force (APM) Pahang State by Mohd Raizalhilmy, Mohd Rais

“…Kamal Zuhairi Zamli, who is also the Deputy Vice-Chancellor (Research and Innovation) of UMPSA.…”
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Sympathetic-neuron-derived neuropeptide Y (NPY) regulates adipose tissue immunometabolic homeostasis by Zhu, Y

“…This defect is replicated in conditional knockout (cKO) mice with NPY specifically abrogated from sympathetic neurons. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…The results show that Hif-1α protein and HIF targets were upregulated in left ventricular tissue of α-MHC719/+ mice. Cardiomyocyte-specific abolishment of Hif-1a blunted the disease phenotype, as evidenced by decreased left ventricular wall thickness, reduced myocardial fibrosis, disordered SRX/DRX state and ROS production. cHif1aKO induced normalization of pro-hypertrophic and pro-fibrotic left ventricular remodeling signaling evidenced on whole transcriptome and proteomics analysis in α-MHC719/+ mice. …”

Building a Scalable Electrification Infrastructure in Logistics by Alam, Muhammad Ashhad

“…A key pathway toward freight decarbonization, therefore, involves shifting from internal combustion engines (ICE) to electric powertrains in truck fleets. This work develops analytics-based solutions to support and assess the electrification of long-haul logistics operations, by applying the methods to PepsiCo’s operations in Texas.…”
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Development of scaffolds for oesophageal tissue engineering by Leong, Meng Fatt

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Knowledge and skills required to set up and operate clean energy communities by Golob, U, Kamin, T, Barnes, JPJ

Cross-modal size-contrast illusion : acoustic increases in intensity and bandwidth modulate haptic representation of object size by Uesaki, Maiko, Ashida, Hiroshi, Kitaoka, Akiyoshi, Pasqualotto, Achille

“…In this study, a series of images each comprising a pair of pine-tree figures were translated into auditory modality using sensory substitution software. …”
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Structural performance of recycled aggregate concrete-filled stainless steel tube columns by Tan, Chia Wei

“…The experiment involved 12 RACFSST columns tested under pin-ended condition, as well as material tests and initial global geometric imperfection measurements. …”
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Design and 3D printing of reconfigurable structures by Teo, Ee Hian

“…The structure is made up of single modular units being repeatedly fixed together, this leads to the structure to isolate single modular units that are damaged, allowing it to be easily pin-pointed and replaced by fabricating another similar single unit, this cut cost as the structure can be salvaged by replacing a single unit instead of the whole structure.…”
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Tie the knot - a step by step wedding planner by Alex Arvin S Susaipillai

“…The creation comprises essential management tools such as wedding checklist, reminders, budget tracker, guestlist, online electronic invitation and RSVP system with SMS function, seating plan, calendar function, vendor list, pin board, wedding day scheduler and chat function…”
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