Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification by Chan, Hung, Li, Qing, Wang, Xiansong, Liu, Wing Yingzhi, Hu, Wei, Zeng, Judeng, Xie, Chuan, Kwong, Thomas Ngai Yeung, Ho, Idy Hiu Ting, Liu, Xiaodong, Chen, Huarong, Yu, Jun, Ko, Ho, Chan, Raphael Chiu Yeung, Ip, Margaret, Gin, Tony, Cheng, Alfred Sze Lok, Zhang, Lin, Chan, Matthew Tak Vai, Wong, Sunny Hei, Wu, William Ka Kei

“…Restoring MITF function by enforced MITF expression or restoring lysosome acidification with 1α,25-dihydroxyvitamin D3 or carbamazepine suppressed pro-inflammatory cytokine expression in vitro. In mice, gavage with TcdB-hyperproducing C. difficile or injection of TcdB into ligated colon segments caused prominent MITF downregulation in macrophages. …”
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Growth hormone increases BDNF and mTOR expression in specific brain regions after photothrombotic stroke in mice by Sanchez-Bezanilla, Sonia, Beard, Daniel J., Hood, Rebecca J., Åberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jörgen, Ong, Lin Kooi

“…Recombinant human growth hormone (r-hGH) or saline was delivered (0.25 μl/hr, 0.04 mg/day) to mice for 28 days, commencing 48 hours after photothrombotic stroke. …”
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Profiling pro-inflammatory proteases as biomolecular signature of material-induced subcutaneous host response in immuno-competent mice by Tran, Nam M. P., Truong, Anh T. H., Nguyen, Dang T., Dang, Tram Thuy

“…Herein, we comprehensively profile molecular expression and proteolytic activity of three distinct proteases, namely neutrophil elastase, matrix metalloproteinases (MMP), cysteine cathepsins (cathepsin-K and cathepsin-B), in the subcutaneous host response of immuno-competent mice against different biomaterial implants. Quantitative non-invasive monitoring with activatable fluorescent probes reveals that different microparticulate materials induce distinct levels of protease activity with degradable PLGA inducing the strongest signal compared to nondegradable materials such as polystyrene and silica oxide. …”
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Space charge induced beam loss on a high intensity proton synchrotron by Pine, B

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…Here, we report the discovery and characterization of three distinct m3C-contributing enzymes in mice and humans. We found that methyltransferase-like (METTL) 2 and 6 contribute m3C in specific tRNAs and that METTL8 only contributes m3C to mRNA. …”
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Efficient multi-scale representation of visual objects using a biologically plausible spike-latency code and winner-take-all inhibition by Sanchez-Garcia, Melani, Chauhan, Tushar, Cottereau, Benoit R., Beyeler, Michael

“…We demonstrate that a network of 200 spiking neurons tuned to three SFs can efficiently represent objects with as little as 15 spikes per neuron. …”
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Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer by Alsaiari, Shahad K., Nadeef, Seba, Daristotle, John L., Rothwell, William, Du, Bujie, Garcia, Johnny, Zhang, Linzixuan, Sarmadi, Morteza, Forster, Timothy A., Menon, Nandita, Lin, Stacey Qiaohui, Tostanoski, Lisa H., Hachmann, Nicole, Wang, Erika Yan, Ventura, John D., Barouch, Dan H., Langer, Robert, Jaklenec, Ana

“…The intrinsic adjuvant properties of ZIF-8, along with the efficient delivery and biomimetic presentation of a severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain trimer, primed rapid humoral and cell-mediated immunity in a dose-sparing manner. …”
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Cognitive Effects of Simulated Galactic Cosmic Radiation Are Mediated by ApoE Status, Sex, and Environment in APP Knock-In Mice by Wieg, Laura, Ciola, Jason C., Wasén, Caroline C., Gaba, Fidelia, Colletti, Brianna R., Schroeder, Maren K., Hinshaw, Robert G., Ekwudo, Millicent N., Holtzman, David M., Saito, Takashi, Sasaguri, Hiroki, Saido, Takaomi C., Cox, Laura M., Lemere, Cynthia A.

“…While simulated galactic cosmic radiation (GCRsim) has led to memory deficits in wildtype (WT) mice, it has not been investigated whether GCRsim in combination with genetic risk factors for Alzheimer’s disease (AD) worsens memory further in aging mice. …”
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Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice by Ivan, Fransiskus Xaverius, Kwoh, Chee Keong

“…Many individual studies have been carried out in mice to uncover the viral factors responsible for the virulence of IAV infections. …”
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Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses by Chauffour, Aurélie, Robert, Jérôme, Veziris, Nicolas, Aubry, Alexandra, Pethe, Kevin, Jarlier, Vincent

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Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility by Kurochkin, Igor V., Alkuraya, Fowzan S., Iwasa, Hiroyasu, Akita, Masumi, Tsukui, Tohru, Ito, Chizuru, Shimozawa, Nobuyuki, Iseki, Mioko, Mizuno, Yumi, Ninomiya, Yuichi, Nakachi, Yutaka, Toshimori, Kiyotaka, Nishimukai, Megumi, Hara, Hiroshi, Maeba, Ryouta, Okazaki, Tomoki, Alodaib, Ali Nasser Ali, Amoudi, Mohammed Al, Jacob, Minnie, Horai, Yasushi, Watanabe, Mitsuhiro, Motegi, Hiromi, Wakana, Shigeharu, Noda, Tetsuo, Mizuno, Yosuke, Schönbach, Christian, Okazaki, Yasushi

“…To clarify the in vivo functions and physiological role of Tysnd1, we analyzed the phenotype of Tysnd1-/- mice. Male Tysnd1-/- mice are infertile, and the epididymal sperms lack the acrosomal cap. …”
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Effects of tea seed oil extracted by different refining temperatures on the intestinal microbiota of high-fat-diet-induced obese mice by Chen, Lin, Jiang, Qihong, Lu, Hongling, Jiang, Chenkai, Hu, Wenjun, Liu, Hanxiao, Xiang, Xingwei, Tan, Chin Ping, Zhou, Tianhuan, Shen, Guoxin

“…T-TSO and N-TSO mice were given traditionally refined and optimized tea seed oil for 12 weeks. …”
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Modulatory effects of isolated Lactobacillus paracasei from Malaysian water kefir grains on the intestinal barrier and gut microbiota in diabetic mice by Talib, Noorshafadzilah, Mohamad, Nurul Elyani, Chai, Ling Ho, Masarudin, Mas Jaffri

“…Results indicated that the administration of isolated Lactobacillus paracasei from MWKG to diabetic mice ameliorated the dominant probiotic phyla in the gut microbiota. …”

闽西北农村环境污染对闽江水质影响的研究 = Effect of agricultural pollutants in north-west Fujian Province on Ming Jiang water quality by 游诗祥 You, Shixiang, 黄月珍 Huang, Yuezhen, 吴成城 Wu, Chengcheng

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Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice by Wadduwage, Dushan N., Kay, Jennifer, Singh, Vijay Raj, Kiraly, Orsolya, Sukup-Jackson, Michelle R., Rajapakse, Jagath, Engelward, Bevin P., So, Peter T. C.

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Effect of Pueraria mirifica subchronic treatments on ameliorating depression by increasing tryptophan hydroxylase immunoreactive neurons via estrogen receptors in ovariectomized mice by Nattawut Tadsaichol, Wandee Udomuksorn, Ekkasit Kumarnsit, Uraporn Vongvatcharanon, Surapong Vongvatcharanon

“…Therefore, this study aimed to investigate the effect of PM on depression-like behavior, density of tryptophan hydroxylase immunoreactive (TPH-ir) neurons and intensity of estrogen receptor a (ERa) and b (ERb) in dorsal raphe nucleus (DRN) in ovariectomized (OVX) mice. Adult female IRC mice were divided into 7 groups: (1) Sham-operates (SHAM), (2) OVX and distilled water treated (PM0), (3) OVX and 40 mg/kg estradiol benzoate treated (E40), OVX and ethanolic extract of PM treated for 90 days at various doses (4) 25 mg/kg (PM25), (5) 50 mg/kg (PM50), (6) 100 mg/kg (PM100) and (7) OVX and 20 mg/kg fluoxetine treated for 20 days. …”
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The cellular characterization of SARS-CoV-2 spike protein in virus-infected cells using the receptor binding domain binding specific human monoclonal antibodies by Chan, Conrad En-Zuo, Ng, Ching-Ging, Lim, Angeline Pei-Chew, Seah, Shirley Lay-Kheng, Chye, De-Hoe, Wong, Steven Ka-Khuen, Lim, Jie-Hui, Lim, Vanessa Zi-Yun, Lai, Soak-Kuan, Wong, Pui-San, Leong, Kok-Mun, Liu, Yi-Chun, Sugrue, Richard J., Tan, Boon Huan

“…While all five antibodies bound conformational-specific epitopes within SARS-CoV-2 spike (S) protein, only PD5, PD7, and SC23 were able to bind to the receptor binding domain (RBD). …”
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Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice by Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra

“…Here, we have assessed in vivo glycemic responses to the pharmacological GLP-1R agonist exendin-4 in adult β cell-specific β-arrestin 2 knockout (KO) mice. KOs displayed a sex-dimorphic phenotype consisting of weaker acute responses that improved 6 hours after agonist injection. …”
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Virus-like particles of nodavirus displaying the receptor binding domain of SARS-CoV-2 spike protein: a potential VLP-based COVID-19 vaccine by Kumar, Kiven, Tan, Wen Siang, Arshad, Siti Suri, Ho, Kok Lian

“…The receptor binding domain (RBD) of the virus spike (S) glycoprotein has been extensively used in vaccine development due to its role in host cell attachment and penetration. …”
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Translating decoration and symbolism of Chinese architectural works in tourism texts : a case study of Nan Hai Ming Zhu Tian Fu Gong (Pearl of the South Seas——Thian Hock Keng) by Koh, Qiumei

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