Sympathetic-neuron-derived neuropeptide Y (NPY) regulates adipose tissue immunometabolic homeostasis by Zhu, Y

“…This defect is replicated in conditional knockout (cKO) mice with NPY specifically abrogated from sympathetic neurons. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…The results show that Hif-1α protein and HIF targets were upregulated in left ventricular tissue of α-MHC719/+ mice. Cardiomyocyte-specific abolishment of Hif-1a blunted the disease phenotype, as evidenced by decreased left ventricular wall thickness, reduced myocardial fibrosis, disordered SRX/DRX state and ROS production. cHif1aKO induced normalization of pro-hypertrophic and pro-fibrotic left ventricular remodeling signaling evidenced on whole transcriptome and proteomics analysis in α-MHC719/+ mice. …”

Structural performance of recycled aggregate concrete-filled stainless steel tube columns by Tan, Chia Wei

“…The experiment involved 12 RACFSST columns tested under pin-ended condition, as well as material tests and initial global geometric imperfection measurements. …”
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Design and 3D printing of reconfigurable structures by Teo, Ee Hian

“…The structure is made up of single modular units being repeatedly fixed together, this leads to the structure to isolate single modular units that are damaged, allowing it to be easily pin-pointed and replaced by fabricating another similar single unit, this cut cost as the structure can be salvaged by replacing a single unit instead of the whole structure.…”
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Tie the knot - a step by step wedding planner by Alex Arvin S Susaipillai

“…The creation comprises essential management tools such as wedding checklist, reminders, budget tracker, guestlist, online electronic invitation and RSVP system with SMS function, seating plan, calendar function, vendor list, pin board, wedding day scheduler and chat function…”
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Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging by Xie, Chen, Upputuri, Paul Kumar, Zhen, Xu, Pramanik, Manojit, Pu, Kanyi

“…By virtue of the targeting capability of cyclic-RGD, the amplified SPN can effectively delineate tumor in living mice and increase the PA intensity of tumor by 4.7-fold after systemic administration. …”
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Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis by Ma, J

“…</p> <p>By monitoring the spontaneous tumour formation in mice, it was found that a lack of FIH expression does not profoundly affect the lifespan but accelerates the development of low-grade B cell lymphomas. …”

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress by Rodrigues, B, Leitão, RA, Santos, M, Trofimov, A, Silva, M, Inácio, ÂS, Abreu, M, Nobre, RJ, Costa, J, Cardoso, AL, Milosevic, I, Peça, J, Oliveiros, B, Pereira de Almeida, L, Pinheiro, PS, Carvalho, AL

“…Additionally, viral overexpression of miR-186-5p in the PFC of naïve mice induces anxiety- and depressive-like behaviours. …”

A cellular basis for mapping behavioural structure by El-Gaby, M, Harris, AL, Whittington, JCR, Dorrell, W, Bhomick, A, Walton, ME, Akam, T, Behrens, TEJ

“…The mice discovered the underlying task structure, enabling zero-shot inferences on the first trial of new tasks. …”

Functional integrity of visual coding following advanced photoreceptor degeneration by Rodgers, J, Hughes, S, Lindner, M, Allen, AE, Ebrahimi, AS, Storchi, R, Peirson, S, Lucas, RJ, Hankins, MW

“…Units from the WT and <em>ReaChR rd1</em> mice clustered together when subjected to unsupervised community detection based on stimulus-response properties. …”

Developing optogenetics for use in vascular research by Rorsman, N

“…</p> <p>2) Transgenic mice expressing ChR2(H134R) selectively in SMCs were generated. …”

Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor by Pang, Kuin Tian, Ghim, Mean, Liu, Chenghao, Tay, Hui Min, Fhu, Chee Wai, Chia, Rui Ning, Qiu, Beiying, Sarathchandra, Padmini, Chester, Adrian H., Yacoub, Magdi H., Wilkinson, Fiona L., Weston, Ria, Warboys, Christina M., Hou, Han Wei, Weinberg, Peter D., Wang, Xiaomeng

“…Causality between LRG1 and TNFR1 shedding was established by showing that Lrg1 -/- mice had lower plasma sTNFR1 concentrations than wild type mice. …”
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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior by Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Brauer, Bastian, Merino-Veliz, Nicolas, Droste, Rita, Arancibia, Felipe, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E., Bustos, Fernando J.

“…In mice, mosaic KO of VPS50 in the hippocampus altered synaptic transmission and plasticity and generated robust cognitive impairments. …”
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Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria by Panda, Saswati, Zhang, Jing, Tan, Nguan Soon, Ho, Bow, Ding, Jeak Ling

“…AID−/− mice lacking IgG were susceptible to infection, unless reconstituted with natural IgG. …”
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Diffuse Correlation Spectroscopy (DCS) and Diffuse Optical Spectroscopy (DOS) for photodynamic therapy monitoring. by Siti Raudhah Matyasir.

“…Other parameters used are illumination time, light dose of PDT and fluence rate. Almost all mice went through photodynamic therapy at least twice. …”
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Functional genetics of cancer and congenital disorders by Zak, J

“…Examining new and published patients with 1q41q42 microdeletions, we found that <em>TP53BP2</em>, encoding ASPP2, is a strong candidate for being the gene responsible for brain morphological abnormalities of the syndrome. Mice deficient for <em>Trp53bp2</em> show multiple abnormalities overlapping the features of the 1q41q42 microdeletion syndrome such as dysmorphic lateral ventricles, heart and urogenital abnormalities. …”

Developing a personalized heterologous prime boost vaccination strategy for tumor therapy by Ramirez-Valdez, RA

“…In this study, a novel intravenous (IV) heterologous prime-boost vaccination strategy with a self-assembling neoantigen-peptide nanoparticle TLR-7/8 agonist (SNP) vaccine platform and a chimp adenovirus (ChAdOx1) was used to elicit high magnitude neoantigen-specific CD8 T cells and modulate the TME. Mice primed with SNP encoding the neoantigen Reps1 for a colon carcinoma (MC38) and boosted with ChAdOx1 IV encoding Reps1 elicited on average ~40% Reps1-specific CD8 T cell responses, which were ~4x higher than mice boosted by the conventional IM route. …”

Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation and molecular docking of mahogany seed extract (Swietenia mahagoni) as anti-hyperglycemic by Mushawwir Taiyeb, Mushawwir Taiyeb, Hartati Hartati, Hartati Hartati, Arwansyah Arwansyah, Arwansyah Arwansyah, Dahlia, Dahlia, Abd. Muis, Abd. Muis, A. Mu'nisa, A. Mu'nisa, Arif, Abdur Rahman, Md. Salleh, Liza

“…So, research was carried out to determine the formulation and optimization of nanoemulsion from mahogany seed extract (Swietenia mahagoni) and its effect on reducing blood glucose levels in mice (Mus musculus L.). Based on research that has been carried out, the nanoemulsion formula for mahogany seed extract is characterized by a transmittance percentage of 84.7 % and a particle size of 12.21 nm. …”
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Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8⁺ T cells by Kang, Xing, Liu, Changan, Ding, Yanqiang, Ni, Yunbi, Ji, Fenfen, Lau, Harry Cheuk Hay, Jiang, Lanping, Sung, Joseph Jao Yiu, Wong, Sunny Hei, Yu, Jun

“…R. intestinalis administration significantly inhibited tumour formation in Apc(Min/+) mice, which was confirmed in mice with AOM-induced CRC. …”
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Finite element analysis on post-buckling of thin-walled structures using ANSYS by Theint, Yi Mon

“…The results obtained were checked against experimental data and led to the development and the revision of design procedures for the pin-ended lipped column and hollow box section.…”
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