Targeting NAPE-PLD: assessing its potential in the fight against malaria by Goh, Xiu Ling

“…This calls for an increased need for discovering novel ring-stage drug targets. In this study, we aimed to investigate the compensatory mechanism of N-acyl phosphatidylethanolamine Phospholipase D (NAPE-PLD) and 14 in P. falciparum and assess if they could be potential ring-stage targets. …”
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The algebraic K-theory of the chromatic filtration and the telescope conjecture by Levy, Ishan

“…Using this and an extension of the Dundas--Goodwillie--McCarthy theorem to —1-connective ring spectra, we obtain a formula for the algebraic K-theory of the K(1)-local sphere in terms of topological cyclic homology of a ring spectrum j_zeta, and in particular find that its algebraic K-groups are not all finitely generated. …”
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Re-understanding the mechanisms of action of the anti-mycobacterial drug bedaquiline by Sarathy, Jickky Palmae, Gruber, Gerhard, Dick, Thomas

“…A direct mechanism involves BDQ binding to the enzyme’s c-ring to block its rotation, thus inhibiting ATP synthesis in the enzyme’s catalytic α3β3-headpiece. …”
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Characterisation of negative curvature hollow core optical fibers by Gu, Nancy

“…Finally, Solid Core Fibers are studied, characterised and compared with Single Ring Negative Curvature Hollow Core Fibers in terms of light guiding properties.…”
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2-amino-5-chloropyrimidin-1-ium hydrogen maleate by Fun, Hoong-Kun., Hemamalini, Madhukar., Rajakannan, Venkatachalam.

“…In the roughly planar (r.m.s. deviation = 0.026 Å) hydrogen malate anion, an intramolecular O-HO hydrogen bond generates an S(7) ring. In the crystal, the protonated N atom and the 2-amino group of the cation are hydrogen bonded to the carboxylate O atoms of the anion via a pair of N-HO hydrogen bonds, forming an R22(8) ring motif. …”
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Automated coding of implicit motives : a machine-learning approach by Pang, Joyce S., Ring, Hiram

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Is there a role for traction forces exerted at the polar regions in the cytokinesis of adherent cells? by Foo, Jasmine Mao Shan.

“…In cytokinesis, the division of the cytoplasm of the mother cell to form two daughter cells has long been known to be accomplished by furrow ingression through constriction of the contractile ring. Recent studies suggested that adherent cells could divide without the contractile ring, in an adhesion-dependent manner by producing traction forces. …”
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Catalytic synthesis of azeheterocycles from organic azides. by Toh, Kah Kah.

“…One electron oxidation of bicyclic cyclopropanol, bicyclo[4.1.0]heptan-1-ol by a catalytic amount of Mn(III) promotes ring-expansion to afford 7-membered-ring β-carbonyl radical, which adds to vinyl azide to form an iminyl radical with elimination of dinitrogen. …”
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Design and experiment on Silicon photonic sensor by Nurhidayah Abdul Rahman Tan

“…The design is based on a rectangular/planar waveguide and also ring resonators. The material used for the rectangular waveguide is Silicon while the ring resonators used Silicon and Glass. …”
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Tunable optical and dielectric properties of metal phthalocyanine based coatings as passive camouflage materials by Poh, Jia Chin

“…After the analysis of the characterization techniques, it is found that the substituting the metallic species in the phthalocyanine ring can indeed alter the optical and dielectric properties of the phthalocyanine coating.…”
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Transverse domain wall profile for spin logic applications by Ramu, Maddu, Murapaka, Chandrasekhar, Goolaup, Sarjoosing

“…The topological defects of Transverse DWs (TDW) are of paramount importance as regards to the deterministic pinning and movement of DW within complex networks of conduits. …”
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Cell-based assays in flowing and sessile drops by Prastowo, A

“…The impact of this arrangement on cells, and the alternation of the pinning line/interface by Fetal Bovine Serum (FBS) is examined in some details. …”

Target Design and Optimizations for Spent Fuel Transmutation by Tukharyan, Grigor

“…A proposed tank design with a lead/Tc-99 target that is surrounded by LLFP pins and heavy water is considered for the spallation study. …”
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Estimating permeability function of soil from mini-disk infiltrometer tests by Muhammad Amirul Haziq Yahya

“…Current in-situ methods to investigate infiltration such at the single ring and double ring permeameters and disc infiltrometer are bulky and takes a lot of effort to transport and apply. …”
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Organogel formation by a cholesterol-stoppered bistable [2]rotaxane and its dumbbell precursor by Zhao, Yanli, Aprahamian, Ivan, Trabolsi, Ali, Erina, Natalia, Stoddart, J. Fraser

“…The cyclobis(paraquat-p-phenylene) ring in the [2]rotaxane can be switched between the tetrathiafulvalene and 1,5-dioxynaphthalene recognition units by addressing the redox properties of the tetrathiafulvalene unit. …”
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A bistable pretzelane by Zhao, Yanli, Trabolsi, Ali, Stoddart, J. Fraser

“…A switchable donor–acceptor pretzelane composed of a crown ether containing tetrathiafulvalene and 1,5-dihydroxynaphthalene recognition units and a covalently tethered cyclobis(paraquat-pphenylene) ring exhibits unidirectional motion on both oxidation (forwards) and reduction (backwards).…”
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Whole-cell phenotypic screening of Medicines for Malaria Venture Pathogen Box identifies specific inhibitors of Plasmodium falciparum late-stage development and egress by Patra, Alok Tanala, Hingamire, Tejashri, Belekar, Meenakshi A., Xiong, Aoli, Subramanian, Gowtham, Bozdech, Zbynek, Preiser, Peter, Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh

“…We identified 90 molecules with EC50 of ≤1 μM, which had significant effect on the ring-trophozoite transition, while 9 molecules inhibited the trophozoite-schizont transition and 21 molecules inhibited the schizont-ring transition (with ≥50% parasites failing to proceed to the next stage) at 1 μM. …”
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Hermitian self-dual abelian codes by Jitman, Somphong, Ling, San, Solé, Patrick

“…Hermitian self-dual abelian codes in a group ring Fq2 [G], where Fq2 is a finite field of order q2 and G is a finite abelian group, are studied. …”
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Innovative UWB phase shifters using groove gap-waveguide technology inspired by metasurfaces for beamforming networks operating at 100 GHz by Alibakhshikenari, Mohammad, Zidour, Ali, Virdee, Bal Singh, Kouhalvandi, Lida, Shahid, Saleem, See, Chan Hwang, Limiti, Ernesto

“…The metasurface features a "bed-of-nails" structure, where metal pins are connected to a bottom layer and spaced <λ/4 from a top plate. …”
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Molecular architecture of the Chikungunya virus replication complex by Tan, Yaw Bia, Chmielewski, David, Law, Michelle Cheok Yien, Zhang, Kuo, He, Yu, Chen, Muyuan, Jin, Jing, Luo, Dahai

“…Within the core RNA replicase, the viral polymerase nsP4, which is in complex with nsP2 helicase-protease, sits in the central pore of the membrane-anchored nsP1 RNA-capping ring. The addition of a large cytoplasmic ring next to the C terminus of nsP1 forms the holo-RNA-RC as observed at the neck of spherules formed in virus-infected cells. …”
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