Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…</p> <p><strong><em>Conclusion:</em></strong> Our study has demonstrated that ubiquitination of the DPC substrates is a key pathway in regulating SPRTN activity. These findings will not only contribute to the understanding of the mechanisms by which SPRTN proteolysis in DPCs repair, but also provide a powerful <em>in vitro</em> approach for drug screening to develop new cancer treatment strategies.…”

Frailty, multimorbidity and polypharmacy: exploratory analyses of the effects of empagliflozin from the EMPA-KIDNEY trial by Mayne, KM, Sardell, R, Staplin, N, Judge, P, Zhu, D, Sammons, E, Wanner, C, Emberson, J, Preiss, D, Landray, M, Baigent, C, Haynes, R, Herrington, W

“…</p> <br> <p><strong>Conclusions:</strong> These findings support the use of SGLT2 inhibitors in CKD, irrespective of frailty, multimorbidity or polypharmacy.…”

Enhancing trauma triage in low-resource settings using machine learning: a performance comparison with the Kampala Trauma Score by Nsubuga, M, Kintu, TM, Please, H, Stewart, K, Navarro, SM

“…Conclusion: ML models demonstrated superior predictive capabilities over the KTS in predicting triage decisions, even when utilising a limited set of injury information about the patients. These findings suggest a promising opportunity to advance trauma care in LMICs by integrating ML into triage decision-making. …”

Structure of a fully assembled γδ T-cell antigen receptor by Gully, BS, Ferreira Fernandes, J, Gunasinghe, SD, Vuong, MT, Lui, Y, Rice, MT, Rashleigh, L, Lay, C-S, Littler, DR, Sharma, S, Santos, AM, Venugopal, H, Rossjohn, J, Davis, SJ

“…Reducing this conformational heterogeneity by transferring the V&delta;3V&gamma;8 TCR variable domains to an &alpha;&beta; TCR enhanced receptor signaling, suggesting that &gamma;&delta; TCR organization reflects a compromise between efficient signaling and the ability to engage structurally-diverse ligands. Our findings reveal the remarkable structural plasticity of the TCR on evolutionary timescales, and recast it as a highly versatile receptor capable of initiating signaling as either a rigid or flexible structure.…”

RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Lentzen, M, Vairavan, S, Muurling, M, Alepopoulos, V, Atreya, A, Boada, M, de Boer, C, Conde, P, Curcic, J, Frisoni, G, Galluzzi, S, Gjestsen, MT, Gkioka, M, Grammatikopoulou, M, Hausner, L, Hinds, C, Lazarou, I, de Mendonça, A, Nikolopoulos, S, Religa, D, Scebba, G, Jelle Visser, P, Wittenberg, G, Narayan, V

“…The machine-learning-based analysis demonstrated that RMT-based models could identify subjects in the prodromal stage with an Area Under the ROC Curve of 73.0 %. In addition, our findings show that the Amsterdam iADL questionnaire has high discriminatory abilities. …”

Immunological screening of Lassa virus among health workers and contacts of patients of Lassa fever in Ondo State by Shaibu, JO, Salu, OB, Amoo, OS, Idigbe, I, Musa, AZ, Ezechi, OC, Abejegah, C, Ayodeji, O, Salako, BL, Omilabu, SA, Audu, RA

“…<p><b>Conclusion</b></p> These findings suggest that majority of the health workers are naïve to the virus and hence may be prone to the viral infection. …”

Controls on present-day and future rainfall over southern Africa in coupled climate models by Munday, C

“…Meanwhile, in the subtropical region, intermodel variability in the strength of anomalous northeasterlies across the high topography of Tanzania and Malawi explains 72% of the intermodel spread in rainfall. These findings suggest that improving the representation of the Angola Low, topography and the northeasterly flow should be targets for model development. …”

Extreme rainfall and landslides as a response to human-induced climate change: a case study at Baixada Santista, Brazil, 2020 by Couto de Souza, D, Crespo, NM, Vieira da Silva, D, Harada, LM, Parrode de Godoy, RM, Domingues, LM, Luiz, R, Bortolozo, CA, Metodiev, D, Magalhaes de Andrade, MR, Hartley, A, Cesario de Abreu, R, Li, S, Lott, F, Sparrow, S

“…Our estimates suggest that extreme precipitation events are having shorter return periods due to climate change and increased urbanization and population growth is exposing more people to these events. These findings are especially important for decision-makers in the context of disaster risk reduction and mitigation and adaptation to climate change.…”

Prioritizing questions and topics for the development of guidelines and consensus-based recommendations supported by ILAE: a scoping review and proposal of prioritization criteria by Lin, K, Eyal, S, Demarchi, IG, Ben-Shushan, T, Auvin, S, Khoo, CS, Al-Baradie, R, Sen, A, Newton, C, Ngwende, G, Candez, NM, Sperling, M, Brigo, F, Jette, N, Wiebe, S

“…We searched Medline/PubMed, Embase, Web of Science, and Scopus without time or language limits. The findings were synthesized qualitatively. A consensus-based process was followed to develop a prioritization scoring tool for CPGs and another for CBRs. …”

Understanding health system responsiveness to public feedback at the sub-national level: Insights from Kilifi County, Kenya by Kagwanja, N, Gilson, L, Tsofa, B, Olivier, J, Leli, H, Molyneux, S

“…These gaps ranged from inadequate funding and staffing of feedback mechanisms (hardware), through absence of clear procedures and guidelines (tangible software), to norms, actor relationships and power dynamics (intangible software elements). Our findings are relevant to similar low-and-middle-income contexts and draw attention to the importance of integrating multiple mechanisms and forms of feedback, alongside considering system capacities and their interactions, in strengthening health system responsiveness.…”

The geomorphic work of the European mole (Talpa europaea): long-term monitoring of molehills using structure-from-motion photogrammetry by Baxter, T, Woor, S, Coombes, M, Viles, H

“…In addition, measurements of molehill volume are used to estimate the excavation rate of moles over a month. Findings show that (i) molehills are dynamic landforms that change in size and shape in response to phases of construction, collapse, erosion, and rebuilding, (ii) rates of degradation are influenced by soil characteristics and seasonal weather conditions, (iii) molehills can persist as landscape features for several months, (iv) and moles are capable of moving a substantial volume of sediment in highly active areas (3.89 m³ha^-1 month^-1). …”

Three essays on frictions of trade by Li, W

“…At the same time, sectors producing time-sensitive products benefit more from road construction and improvement. These findings support the claim that intranational trade costs, which have the same impact as international trade costs, are a determinant of comparative advantage and affect international trade patterns.…”

Water quality and prevalence of extended spectrum beta lactamase producing escherichia coli (ESBL E. coli) in Sungai Terengganu, Malaysia by Noor Haza Fazlin Hashim, Muhammad Azroie Mohamed Yusoff, Rachel Trevor Gunggang, Roslina Abdul Razak, Muhamad Zulfatihi Jaafar, Nasehir Khan E.M. Yahaya

“…From 40 presumptive ESBL isolates tested, 87.5% (35 isolates) were positive for ESBL and carried additional drug resistance genes, including mcr-1, tetW, sul-1, and sul-2. These findings indicate a concerning presence of multidrug-resistant E. coli in the river, representing a potential public health risk.…”
Get full text

Sustainable protocols for leaf sample collection in In-Vitro Culture: evaluating the impact of sample bags and hydrogen peroxide pre-sterilization by Nursuria Md Setamam, Norrizah Jaafar Sidik

“…Statistical analyses confirmed the significant impact of sampling bag type and pre-sterilization on contamination levels, necrosis emergence, and leaf longevity. The findings suggest that using low-action vacuum-sealed bags (VSL) with 15% H2O2 pre-sterilization is a promising approach for sustainable leaf sample collection, enhancing the success rate of IVC by minimizing microbial contamination and preserving leaf integrity during transport. …”
Get full text

Examining the effects of relative advances in higher mobility roads over higher accessibility roads and income inequality on the relationship between car ownership and economic gro... by Poi, Alvin Wai Hoong, Law, Teik Hua, Hamid, Hussain, Mohd Jakarni, Fauzan, Ishak, Siti Zaharah, Ng, Choy Peng

“…The implications of these findings on private transportation policies relate to measures to control increased car ownership as well as to reduce road casualties.…”

Exploratory factor analysis: validity and reliability of technology self-efficacy instrument by Noh Mustafa, Fatin Syahirah, Razali, Fazilah, Mohd Puad, Mohd Hazwan

“…The number of components and factor loading values for each item in the technology self-efficacy construct were determined using the Exploratory Factor Analysis (EFA). The EFA findings show five components for the construct of teachers’ technology self-efficacy, each of which has an eigenvalue greater than 1.0. i.e, (based on ISTE-NETS standards) (1) Design & Develop Digital Age-Learning Experiences and Assessments, (2) Engage in Professional Growth and Leadership, (3) Promote and Model Digital Citizenship, (4) Model Digital-Age Work and Learning, (5) Engage in Professional Growth and Leadership. …”
Get full text

Mediation effects of language anxiety and prior learning experience on academic speaking challenges and strategies among Libyan students in Malaysian universities by Halali, Ahlam Ali Salim, Ismail, Lilliati, Abd Samad, Arshad, Razali, Abu Bakar, Noordin, Nooreen

“…NVivo analysis was utilized to code and generate themes from interviews, focus group discussions, and field notes. Findings revealed that Libyan students in Malaysian universities displayed strong self-regulated learning characterized by positive motivation and self-awareness, enabling them to overcome communication challenges through the implementation of various strategies to achieve academic success. …”
Get full text

Pedagogy, ICT skills, and online teaching readiness as factors on digital competency practices among secondary school teachers in Malaysia by Omar, Muhd Khaizer, Mohmad, Ikmal Rizal

“…It is important to note that there was a strong and positive relationship among the studied variables. The findings projected salient integration of the variables to inspire digital competency practices among teachers successfully.…”
Get full text

The influence of Al-Dihlawi’s thoughts about Taklifin Hujjat Allah Al-Balighahon Mohd. Affandi Hassan’s thoughts on Islamic literature in Persuratan Baru by Narmi, Akalily, Abdul Rani, Mohd. Zariat, Kamarudin, Kamariah, Hajimaming @ Toklubok, Pabiyah

“…This study utilises the content analysis method for analysing study materials which are texts. This study finds that al-Dihlawi’s Hujjat Allah al-Balighah among other explicates the philosophy of taklif which refers to the imposition of divine accountability and responsibility upon man. …”
Get full text

Synthesis and characterization of mesoporous expanded graphite modified with PA/H3PO4 for enhanced oil sorption efficiency by Elbidi, Moammar, Mohd Salleh, Mohamad Amran, Gunam Resul, Mohamad Faiz Mukhtar, Rashid, Suraya Abdul

“…FT-IR, XRD, and SEM were used to investigate the functional groups, structures, and morphology of the EG. The findings demonstrated that the interlayers within the natural flake graphite were completely opened and transformed into a structure resembling a fluffy rope, resembling the shape of a worm, upon expansion. …”