Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Global monitoring of volcanic SO2 degassing with unprecedented resolution from TROPOMI onboard Sentinel-5 Precursor by Barrington, Charlotte, Taisne, Benoit, Theys, N., Hedelt, P., De Smedt, I., Lerot, C., Yu, H., Vlietinck, J., Pedergnana, M., Arellano, S., Galle, B., Fernandez, D., Carlito, C. J. M., Delgado-Granados, H., Loyola, D., Van Roozendael, M.

“…Using the operational processing algorithm, we explore the benefit of improved spatial resolution to the monitoring of global volcanic degassing. We find that TROPOMI surpasses any space nadir sensor in its ability to detect weak degassing signals and captures day-to-day changes in SO2 emissions. …”
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Kinematics of Active Deformation Across the Western Kunlun Mountain Range (Xinjiang, China) and Potential Seismic Hazards Within the Southern Tarim Basin by Guilbaud, Christelle, Simoes, Martine, Barrier, Laurie, Laborde, Amandine, Van der Woerd, Jérôme, Li, Haibing, Tapponnier, Paul, Coudroy, Thomas, Murray, Andrew

“…Combining satellite images and DEMs, we achieve a detailed morphological analysis of the Yecheng–Pishan fold, where we find nine levels of incised fluvial terraces and alluvial fans. …”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. …”

Halal beauty supply chain and sustainable operational excellence: A moderator of the post-SARS-CoV-2 mitigation strategy by Fernando, Yudi, Mergeresa, Fineke, Ika Sari, Wahyuni-TD, Nurul Sabrina, Hazarasim

“…This study used a structural equation modeling technique to test the validity of the research model and hypotheses. Findings: This study found that halal transportation, halal manufacturing, halal packaging and post-SARS-CoV-2 mitigation strategies had a significant and direct effect on SOE. …”
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Performance-based identity in a BIM environment : An architect’s perceptions and experiences by Syafizal, Shahruddin, Mohd, Zairul, Ahmad Tarmizi, Haron, Meor Mohammad, Fared

“…The study was conducted in a Malaysian architectural consultancy practice (ACP) setting. Findings: The data analysis resulted in the following five performance identity themes that revolve around the core identity of a successful designer: “performing as a design strategist”, “performing as a design translator”, “performing as a design facilitator”, “reinstating the identity of a design coordinator” and “performing as a design innovator”. …”
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Heat transfer and energy performance analysis of photovoltaic thermal system using functionalized carbon nanotubes enhanced phase change material by Rajamony, Reji Kumar, Pandey, A. K., Mahendran, Samykano, Johnny Koh, Siaw Paw, Kareri, Tareq, Laghari, Imtiaz Ali, Tyagi, V. V.

“…Furthermore, the total efficiency of the PVT system, phase change materials integrated PVT system, and NePCM integrated PVT system were determined to be 81.9 %, 84.5 %, and 85.05 %, respectively. These findings underscore the potential of NePCM-integrated PVT systems for enhancing performance and expanding their practical application.…”
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Evaluating the rheological, chemical and mechanical properties of hybrid asphalt binders and mixtures for enhanced performance by Wan Noor Hin, Mior Sani, Putra Jaya, Ramadhansyah, Khairil Azman, Masri, Amar, Dulaimi

“…Consequently, the hybrid asphalt mixture demonstrated favourable outcomes in improving the hot mix asphalt characteristics. These findings suggested that the hybrid contents (0% as control, 3%, 6%, and 9%) produced a significant performance impact on the hybrid asphalt mixture. …”
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Measuring ethical behavior of accounting graduates in Malaysia: Comparison between perceptual statements and vignettes by Hasnah, Hj Haron, Nurul Nazlia, Jamil, Nathasa Mazna, Ramli, Fatin Arissa, Parsimin, Azim Azuan, Osman

“…This study involved 344 samples of accounting graduates from MIA-accredited universities, and path analysis was performed to test the hypotheses. The findings demonstrate a positive relationship between the ethical workplace culture and ethical behavior among accounting graduates, regardless of whether the ethical behavior was measured using vignette scenarios or perceptual statements. …”
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Data-driven brain emotional learning-based intelligent controller-PID control of MIMO systems based on a modified safe experimentation dynamics algorithm by Shahrizal, Saat, Mohd Ashraf, Ahmad, Mohd Riduwan, Ghazali

“…The comparative results demonstrated that the MSEDA-BELBIC-PID consistently performed better than the original approach and had improved fitness function values, reduced total integral square error, and lower total integral square input. These findings underscored the MSEDA suitability as a data-driven tool for controller design parameter optimization. …”
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Improved methodology for evaluating adversarial robustness in deep neural networks by Lee, Kyungmi,(Computer scientist)Massachusetts Institute of Technology.

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Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism by Pujadas Liwag, Emily M., Wei, Xiaolong, Acosta, Nicolas, Carter, Lucas M., Yang, Jiekun, Almassalha, Luay M., Jain, Surbhi, Daneshkhah, Ali, Rao, Suhas S. P., Seker-Polat, Fidan, MacQuarrie, Kyle L., Ibarra, Joe, Agrawal, Vasundhara, Aiden, Erez Lieberman, Kanemaki, Masato T., Backman, Vadim, Adli, Mazhar

“…Conclusions Our findings suggest that, while B-type lamin degradation does not significantly change genome topology, it has major implications for three-dimensional chromatin conformation at the single-cell level both at the lamina-associated periphery and the non-LAD-associated nuclear interior with concomitant genome-wide transcriptional changes. …”
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Rheo-PIV of yield-stress fluids in a 3D-printed fractal vane-in-cup geometry by Medina-Bañuelos, Esteban F., Marín-Santibáñez, Benjamín M., Chaparian, Emad, Owens, Crystal E., McKinley, Gareth H., Pérez-González, José

“…We describe the velocity distributions in all cases and show that the fVIC produces an almost axisymmetric flow field and rotation rate-independent “effective radius” when used with both the Newtonian fluid and the microgel. These findings are supported by 2D simulation results and enable the safe use of both the Couette analogy and the torque-to-stress conversion scheme for a 24-arm fVIC as well as validate it as a reliable rheometrical tool for characterization of a variety of complex fluids. …”
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Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data by Xu, Xuhai, Yao, Bingsheng, Dong, Yuanzhe, Gabriel, Saadia, Yu, Hong, Hendler, James, Ghassemi, Marzyeh, Dey, Anind K., Wang, Dakuo

“…We also conduct an exploratory case study on LLMs' capability on mental health reasoning tasks, illustrating the promising capability of certain models such as GPT-4. We summarize our findings into a set of action guidelines for potential methods to enhance LLMs' capability for mental health tasks. …”
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Solar-Induced Chlorophyll Fluorescence (SIF): Towards a Better Understanding of Vegetation Dynamics and Carbon Uptake in Arctic-Boreal Ecosystems by Cheng, Rui

“…Additionally, this review proposes applications of SIF across scales in support of other observational and modeling platforms for better understanding Arctic-Boreal vegetation dynamics and carbon fluxes. Recent Findings Cross-scale SIF measurements complement each other, offering valuable perspectives on Arctic-Boreal ecosystems, such as vegetation phenology, carbon uptake, carbon-water coupling, and ecosystem responses to disturbances. …”
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Live Verification in an Interactive Proof Assistant by Gruetter, Samuel, Fukala, Viktor, Chlipala, Adam

“…Program verification requires loop invariants, which are hard to find and tedious to spell out. We explore a middle ground in the design space between the two extremes of requiring users to spell out loop invariants manually and attempting to infer loop invariants automatically: Based on the observation that a loop invariant often looks quite similar to the symbolic state right before the loop, our tool asks users to express the desired loop invariant as a diff from the symbolic state before the loop, which has the potential to lead to less verbose and more maintainable proofs. …”
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Work-Efficient Parallel Derandomization II: Optimal Concentrations via Bootstrapping by Ghaffari, Mohsen, Grunau, Christoph

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Compressed sensing: a discrete optimization approach by Bertsimas, Dimitris, Johnson, Nicholas A. G.

“…We study the Compressed Sensing (CS) problem, which is the problem of finding the most sparse vector that satisfies a set of linear measurements up to some numerical tolerance. …”
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Time-series metagenomics reveals changing protistan ecology of a temperate dimictic lake by Krinos, Arianna I., Bowers, Robert M., Rohwer, Robin R., McMahon, Katherine D., Woyke, Tanja, Schulz, Frederik

“…Our study identified long-term changes in the abundance of eukaryotic microbes and provided context for the known establishment of an invasive species that catalyzes a trophic cascade involving protists. Our findings are important for decoding potential long-term consequences of human interventions, including invasive species introduction.…”
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