Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex by Asamitsu, Sefan, Obata, Shunsuke, Phan, Anh Tuân, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi

“…By means of circular dichroism (CD), fluorescence resonance energy transfer (FRET), surface plasmon resonance (SPR), and NMR techniques, we showed the dual and simultaneous recognition of the respective segment via hybrid molecules, and the synergistic and mutual effect of each binding component that was appropriately linked on higher binding affinity and modest sequence specificity. …”
Get full text

Ultracompact high-sensitivity biosensing based on regenerable laminated bio-conjugation in integrated photonic circuits by Li, Z. Y., Chen, Y. Y., Xiong, S., Truc, N. K., Xiong, Q. H., Liu, Ai Qun

“…LOD can be improved to 30 ng/mL after linking the detection antibody. After associating with the layer-by-layer structure composed by HRP and anti-HRP antibody on the sandwich assay, LOD can be improved to several pg/mL. …”
Get full text

Insight into the lateral ride discomfort thresholds of young-adult bus passengers at multiple postures : case of Singapore by Nguyen, Teron, NguyenDinh, Nen, Lechner, Bernhard, Wong, Yiik Diew

“…Lateral ride discomfort thresholds were thus established for bus negotiating roundabouts, intersections and along links. The three levels of ride discomfort are Uncomfortable, Very Uncomfortable and Extremely Uncomfortable with average lateral accelerations of ay = 1.5, 1.75 and 2.0 m/s2, respectively. …”
Get full text

Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…Our data suggest that Tis11b may play a role during B cell activation processes and SB1/56.6 antibody could be used in cross-linking immunoprecipitation (CLIP) experiment to identify full spectrum of RNA targets of Tis11b. …”
Get full text

The relationship between self-perceived burden, depression, medication adherence, and health-related quality of life in coronary heart disease patients by Lim, Benjamin Chee Chong

“…Although self-perceived burden has been consistently linked to health-related quality of life (HRQOL), its underlying mechanisms remain unexplored, particularly in coronary heart disease (CHD) patients. …”
Get full text

Continuous treatment of the organic fraction of municipal solid waste in an anaerobic two-stage membrane process with liquid recycle by Trzcinski, A.P., Stuckey, David Campbell

“…The operation was not sustainable below this HRT due to a membrane flux limitation at 0.5–0.8 L/m2 h (LMH), which was linked to the increasing MLTSS. SCOD in the recycled permeate did not build up indicating a slow degradation of recalcitrants over time. …”
Get full text
Get full text

MEG Insight into the Spectral Dynamics Underlying Steady Isometric Muscle Contraction by Bourguignon, Mathieu, Piitulainen, Harri, Smeds, Eero, Zhou, Guangyu, Jousmäki, Veikko, Hari, Riitta

“…Thus, ∼20 Hz coherence between cortex and periphery is tightly linked to the presence of ∼20 Hz bursts in SM1 and peripheral activity. …”
Get full text
Get full text

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections by Kam, Yiu-Wing, Lee, Cheryl Yi-Pin, Teo, Teck-Hui, Howland, Shanshan W., Siti Naqiah Amrun, Lum, Fok-Moon, See, Peter, Kng, Nicholas Qing-Rong, Huber, Roland G., Xu, Mei-Hui, Tan, Heng-Liang, Choo, Andre, Maurer-Stroh, Sebastian, Ginhoux, Florent, Fink, Katja, Wang, Cheng-I, Ng, Lisa F.P., Rénia, Laurent

“…Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. …”
Get full text
Get full text

Taste and see: real presence as revelation in Heideggerian perspective by Olson, JW

“…Heidegger’s notion of Being-in-the-world opens up a new definition of understanding, where what is primary is praxis in the form of worldly involvement, so that understanding in the form of habits, mood, and know-how becomes foundational for any knowledge of the beings with which we interact. Language is then linked up with this pre-reflective understanding, first as discourse and then later as poetry, both of which disclose a fundamental world-orientation to language.…”

Mapping the extent and exploring the drivers of cocoa agroforestry in Nigeria, insights into trends for climate change adaptation by Koralewicz, A, Vlcek, J, Oliveras-Menor, I, Hirons, M, Akinyugha, A, Sikiru Olowoyo, O, Oluyemi, M, Owen, O

“…In Nigeria, modernization efforts promoting full-sun cocoa have been linked to deforestation and biodiversity loss. The promotion of traditional cocoa agroforestry methods are regaining interest as an approach to climate adaptation and forest restoration. …”

An exploratory study on the development of a sensory wheel affiliated with the emotional lexicon for chrysanthemum infusion by Xia, Y, Hou, J, Chen, J, Spence, C, Qian, J, Zhao, F, Dong, G, Zhong, F

“…However, sensory attributes such as bitterness, astringency, and vegetal aroma were linked to negative emotions and were sometimes associated with feelings of activity. …”

Two for tau: automated model discovery reveals two-stage tau aggregation dynamics in Alzheimer’s disease by Stockman, CA, Goriely, A, Kuhl, E, Jerusalem, A, Alzheimer’s Disease Neuroimaging Initiative

“…Our method reveals previously overlooked two-stage aggregation dynamics by uncovering a twoterm ordinary differential equation that links the local accumulation rate to the tau concentration. …”

The influence of tropical cyclones on mixed-population flood frequency analysis by Wang, L, Gu, X, Slater, LJ, Li, J, Lai, Y, Zhang, X, Dai, J, Chen, Y

“…Our results show that TC-induced floods in inland areas are not always found along the TC path but can be located about 1000 km ahead, which is linked to TC-induced predecessor rain events. Extreme floods associated with TCs are generally larger in coastal areas compared to those in inland areas, whereas TC-induced floods in some inland areas tend to be more extreme relative to their local flood magnitude. …”

External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland by Kerr, S, Millington, T, Rudan, I, McCowan, C, Tibble, H, Jeffrey, K, Fagbamigbe, AF, Simpson, CR, Robertson, C, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR virology testing, hospitalisation and mortality data. …”

Mapping the extent and exploring the drivers of cocoa agroforestry in Nigeria, insights into trends for climate change adaptation by Koralewicz, A, Vlcek, J, Menor, IO, Hirons, M, Akinyugha, A, Olowoyo, OS, Ajayi-Ebenezer, M, Owen, O

“…In Nigeria, modernization efforts promoting full-sun cocoa have been linked to deforestation and biodiversity loss. The promotion of traditional cocoa agroforestry methods are regaining interest as an approach to climate adaptation and forest restoration. …”

Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets by Milosevic, TV, Vertenoeil, G, Vainchenker, W, Tulkens, PM, Constantinescu, SN, Van Bambeke, F

“…Pharmacological interventions to prevent this toxicity might therefore be difficult as mitochondrial toxicity is most probably inherently linked to their antibacterial activity.…”

Treatment of acute sore throat in Malaysia: a consensus of multidisciplinary recommendations using modified Delphi methodology by Abdullah, Baharudin, Koh, Kar Chai, Mohamed, Mohazmi, Tan, Vincent Eng Soon, Mohammad, Nurashikin, Sekawi, Zamberi, Periyasamy, Petrick, Ramadas, Anitha, Duerden, Martin

“…Introduction: Using antibiotics in the treatment of acute sore throats has been linked with antimicrobial resistance (AMR) and needs to be addressed. …”
Get full text

A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications by Abu Bakar, Mohd Fadzelly

“…While hydroxycitric acid (HCA) has been linked to the anti-obesity effects of certain Garcinia fruits, recent research emphasizes the role of garcinol, either alone or in combination, in mediating these effects. …”
Get full text

Distribution and cycling of terrigenous dissolved organic carbon in peatland-draining rivers and coastal waters of Sarawak, Borneo by Martin, Patrick, Cherukuru, Nagur, Tan, Ashleen S. Y., Sanwlani, Nivedita, Mujahid, Aazani, Müller, Moritz

“…DOC and CDOM showed conservative mixing with seawater except in the largest river (the Rajang), where DOC concentrations in the estuary were elevated, most likely due to inputs from the extensive peatlands within the Rajang Delta. …”
Get full text
Get full text

Weather radar to study rain and cloud events by Tan, Xin Yi

“…Such information could help determine or predict weather conditions and characteristics that are useful when establishing communication links. In this report, the author uses Radiosonde information from different cities, weather station information from Nanyang Technological University (NTU) and National University of Singapore (NUS) and the Meteorological Aerodrome Report (METAR) from Singapore Changi Airport. …”
Get full text