Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes by Šimelis, K, Belle, R, Kawamura, A

“…Simultaneous detection of substrate and cofactors is difficult, contributing to a poor understanding of the dynamics between substrate oxidation and 2OG decarboxylation activities. Here, we profile 5-methylcytosine (5mC)-oxidising Ten-Eleven Translocation (TET) enzymes using MS and 1H NMR spectroscopy methods and reveal a high degree of substrate oxidation-independent 2OG turnover under a range of conditions. 2OG decarboxylase activity is substantial (>20% 2OG turned over after 1 h) in the absence of substrate, while, under substrate-saturating conditions, half of total 2OG consumption is uncoupled from substrate oxidation. 2OG kinetics are affected by substrate and non-substrate DNA oligomers, and the sequence-agnostic effects are observed in amoeboflagellate Naegleria gruberi NgTet1 and human TET2. …”

DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts by Kuś, K, Carrique, L, Kecman, T, Fournier, M, Hassanein, SS, Aydin, E, Kilchert, C, Grimes, JM, Vasiljeva, L

“…Xrn2 activity is stimulated by Spt5 to ensure efficient degradation of nascent RNA leading to Pol II dislodgement from DNA. …”

Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

“…Here we show that a single dose of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) affects structural brain plasticity and cognitive flexibility in young adult mice beyond the acute drug experience. …”

Acute inflammatory diseases of the central nervous system after SARS-CoV-2 vaccination by Francis, AG, Elhadd, K, Camera, V, Ferreira Dos Santos, M, Rocchi, C, Adib-Samii, P, Athwal, B, Attfield, K, Barritt, A, Craner, M, Fisniku, L, Iversen, AKN, Leach, O, Matthews, L, Redmond, I, O'Riordan, J, Scalfari, A, Tanasescu, R, Wren, D, Huda, S, Leite, MI, Fugger, L, Palace, J

“…Consequently, the mass SARS-CoV-2 vaccination program could result in increased rates of these conditions. …”

The economic burden of rotavirus hospitalization among children < 5 years of age in selected hospitals in Bangladesh by Ahmed, S, Dorin, F, Satter, SM, Sarker, AR, Sultana, M, Gastanaduy, PA, Parashar, U, Tate, JE, Heffelfinger, JD, Gurley, ES, Khan, JAM

“…<p><strong>Methods</p></strong> We estimated the societal costs of children <5 years for hospitalization from rotavirus gastroenteritis (RVGE) and incidences of catastrophic health expenditure. …”

Northern Borneo stalagmite records reveal West Pacific hydroclimate across MIS 5 and 6 by Carolin, SA, Cobb, KM, Lynch-Stieglitz, J, Moerman, JW, Partin, JW, Lejau, S, Malang, J, Clark, B, Tuen, AA, Adkins, JF

B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination by Kotagiri, P, Mescia, F, Rae, WM, Bergamaschi, L, Tuong, ZK, Turner, L, Hunter, K, Gerber, PP, Hosmillo, M, Hess, C, Clatworthy, MR, Goodfellow, IG, Matheson, NJ, McKinney, EF, Wills, MR, Gupta, RK, Bradley, JR, Bashford-Rogers, RJM, Lyons, PA, Smith, KGC

“…We analyze serial samples from 171 SARS-CoV-2-infected individuals and 63 vaccine recipients and find the global BCR repertoire differs between them. …”

Effect of Co on twin formation and magnetic properties of Sm(Fe,Ti,V)12 alloys by Tozman, P, Hrkac, G, Patrick, CE, Staunton, JB, Saito, T, Sasaki, T, Ohkubo, T, Sepehri-Amin, H

“…Here we have shown that the addition of Co in Sm(Fe_1-xCo_x)_10&ndash;11M_1&ndash;2&nbsp;alloys, where&nbsp;<em>M</em>=Ti and V, leads to an increase in twin density. Microstructural characterizations revealed that the atomic arrangement in the twin boundary changes depending on the stabilizing element, which directly influences the local intrinsic magnetic properties. …”

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England by Copland, E, Patone, M, Saatci, D, Handunnetthi, L, Hirst, J, Hunt, DPJ, Mills, NL, Moss, P, Sheikh, A, Coupland, CAC, Harnden, A, Robertson, C, Hippisley-Cox, J

“…In 12-17-year-olds, we estimated 3 (95%CI 0–5) and 5 (95%CI 3–6) additional cases of myocarditis per million following a first and second dose with BNT162b2, respectively. …”

Tribological properties of three-dimensionally printed Ti-6Al-4V material via electron beam melting process tested against 100Cr6 steel without and with Hank's solution by Khun, Nay Win, Toh, Wei Quan, Tan, Xi Peng, Liu, Erjia, Tor, Shu Beng

“…Three-dimensionally (3D) printed Ti–6Al–4V (Ti64) samples via an electron beam melting (EBM) process were developed to investigate their microstructure and mechanical and tribological properties in comparison with those of commercial Ti64 samples. …”
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Applications of deep learning for physical layer of wireless communication systems by Xie, Yihang

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A Randomized, Double Blind, Placebo-Controlled Human Clinical Trial On The Effects Of Sacha Inchi (Plukenetia Volubilis L.) Oil Supplementation In Hyperglycaemia, Hypertension And... by Mhd Rodzi, Nur Anis Raihana

Subjects: “…T11.95-12.5 Industrial directories…”
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Occlusion handling for augmented reality environment using neural network image segmentation: A review. by Ahmad, Muhammad Anwar, Mohd. Suaib, Norhaida, Ismail, Ajune Wanis

Subjects: “…T58.5-58.64 Information technology…”

Game-based augmented reality learning of Sarawak history in enhancing cultural heritage preservation by Clive, Lai Yi Cheng, Goh, Eg Su, Ahmad, Johanna, Tole Sutikno, Tole Sutikno

Subjects: “…T58.5-58.64 Information technology…”
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Predicting child alimony under Islamic shariah law using hybrid fuzzy inference system by Rosili, Nur Aqilah Khadijah, Hassan, Rohayanti, Zakaria, Noor Hidayah, Che Rose, Farid Zamani, Kasim, Shahreen, Tole Sutikno, Tole Sutikno

Subjects: “…T58.5-58.64 Information technology…”
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Measurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton–proton collisions at $$\sqrt{s}=13\,\text {Te}\hspace{-.08em}\text {V} $$ s = 13 Te V by Tumasyan, A., Adam, W., Andrejkovic, J. W., Bergauer, T., Chatterjee, S., Damanakis, K., Dragicevic, M., Del Valle, A. E., Hussain, P. S., Jeitler, M., Krammer, N., Lechner, L., Liko, D., Mikulec, I., Paulitsch, P., Pitters, F. M., Schieck, J., Schöfbeck, R., Schwarz, D., Sonawane, M.

“…The top quark mass is measured to be $$171.77\pm 0.37\,\text {Ge}\hspace{-.08em}\text {V} $$ 171.77 ± 0.37 Ge V . …”
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The relationship between big five personality and job burnout among secondary school teachers in zone Pasir Gudang, Johor / by Lam, Shi Xian, 1989-, author 644975, Mastura Mahfar, supervisor 644976, Fakulti Pengurusan 538641

The relationship between big five personality and job burnout among secondary school techers in zone Pasir Gudang, Johor / by Lam, Shi Xian, 1989-, author 644975

Capitalizing on a crisis: a computational analysis of all five million British firms during the Covid-19 pandemic by Muggleton, N, Rahal, C, Reeves, A

Complete genome sequences of five bacteria isolated from rice plants in a paddy field in Sekinchan, Selangor, Malaysia by Abdul Malek, Ahmad Zuhairi, Mohd Hashim, Amalia, Khairil Mokhtar, Nur Fadhilah, Saidi, Noor Baity, Abu Bakar, Mohd Faizal, Singaram, Nallamai

“…This study examines the genome sequences of five endophytic bacterial isolates from the Oryza sativa microbiome to assess their potential as plant bio-inoculants. …”
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