A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer by Ho, Cowan, Zhao, Zitong, Chen, Xiu Fen, Sauer, Jan, Saraf, Sahil Ajit, Jialdasani, Rajasa, Taghipour, Kaveh, Sathe, Aneesh, Khor, Li-Yan, Lim, Kiat-Hon, Leow, Wei-Qiang

“…We further trained the composite AI-model's performance on a larger cohort of 105 resections WSIs and then validated our findings on a cohort of 150 biopsies WSIs against the classifications of two independently blinded pathologists. …”
Get full text

Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection by Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne

“…Investigations using patient-derived lymphoblastoid cell line carrying heterozygous RAD51C L134S variant showed an impairment in RAD51 chromatin association and replication fork protection, suggestive of deleteriousness of this VUS variant. Overall, our findings provide more insights into molecular roles of RAD51C in replication fork integrity maintenance and in DSB repair.…”
Get full text

Space weather radiation effects on geostationary satellite solid-state power amplifiers by Lohmeyer, W. Q., Cahoy, K. L.

“…By contrast, a Monte Carlo simulation finds that on average, only 2.8 out of 21 (13%) of randomly assigned anomalies occur between 7 and 14days after an electron flux greater than 1.5 standard deviations above the mean. …”
Get full text

Use of functional magnetic resonance imaging to identify cortical loci for lower limb movements and their efficacy for individuals after stroke by Choi, Minseok, Kim, Hyun-Chul, Youn, Inchan, Lee, Song Joo, Lee, Jong-Hwan

“…Conclusions The cortical loci associated with lower limb movements in the PCL identified in healthy participants were validated using independent groups of healthy participants and individuals after stroke. Our findings suggest that these cortical loci may be beneficial for the neurorehabilitation of lower limb movement in individuals after stroke, such as in developing effective rehabilitation interventions guided by the LI scores obtained for neuronal activations calculated from the identified cortical loci across the paretic and non-paretic sides of the brain.…”
Get full text

Patient and Health Care Worker Perceptions of Communication and Ability to Identify Emotion When Wearing Standard and Transparent Masks by Chu, Jacqueline N., Collins, Joy E., Chen, Tina T., Chai, Peter R., Dadabhoy, Farah, Byrne, James D., Wentworth, Adam, DeAndrea-Lazarus, Ian A., Moreland, Christopher J., Wilson, Jaime A. B., Booth, Alicia, Ghenand, Omkar, Hur, Chin, Traverso, Giovanni

“…CONCLUSIONS AND RELEVANCE: The findings of this study suggest that transparent masks could help improve communication during the COVID-19 pandemic, particularly for individuals who are deaf and hard of hearing.…”
Get full text

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…This combination was the only non-genotoxic conditioning approach that enabled robust donor engraftment post HSCT in WT mice. Conclusion These findings shed new insights into the mechanism of αCD117 mAb-mediated HSC depletion. …”
Get full text

Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…Sulfur–arene interactions appear to tune the reactivity of methionine residues in a manner consistent with rates of oxidation. These findings highlight an underappreciated role for methionine—to protect catalytic histidine residues—and indicate a means by which ptRNases remain functional in oxidatively challenging physiological environments. …”
Get full text
Get full text

Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…This is the first study to examine the relationship between the multi-dimensional filial piety and the work-family interface among working caregivers of the elderly, with considerations of relationship quality and gender. Findings point to potential directions for future research and offer suggestions on how to aid working caregivers to optimize interactions between work and family domains. …”
Get full text

Preliminary environmental risk consideration for small UAV ground risk mapping by Chung, Han Jie, Mohd Hasrizam Che Man, Sivakumar, Anush Kumar, Low, Kin Huat

“…The regions with high rainfall, increased bird population per site and strong signal interference can be extracted.These high-risk locations can be expected to be more hazardous for sUAVs to fly in. Findings for environmental risk-tiering and risk-mapping are preliminary and based on the available environmental data as identified in this study. …”
Get full text

Lactate cross-feeding between Bifidobacterium species and Megasphaera indica contributes to butyrate formation in the human colonic environment by Zhao, Sainan, Lau, Raymond, Zhong, Yang, Chen, Ming-Hsu

“…We concluded that lactate generated by Bifidobacterium through catabolizing xylose fueled the growth of M. indica and triggered the synthesis of butyrate. Our findings demonstrated a novel cross-feeding mechanism to generate butyrate in the human colon. …”
Get full text

Sentiment analysis and summarization of movie reviews across genres. by Tun, Thura Thet.

“…Graphical representation methods such as sentiment bar, sentiment meter, thumbs up/down, sentiment term cloud, sentiment treemap, sentiment time series, aspect-based sentiment summarization and sentiment link analysis graph (named SentiGraph) were implemented and evaluated. The evaluation findings indicate that the participants were generally satisfied with the results of sentiment summarization, and found the proposed approach novel and useful. …”
Get full text

Growth and physical properties of organic semiconducting single crystals by Tan, Ke Jie

“…Therefore, experimental studies aids in finding parameters responsible for the physical properties of materials. …”
Get full text

New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Additionally, expansion of the phytochemical-antibiotic interaction profiles were also carried out with various classes of antibiotics and phytochemicals to understand the interaction patterns by establishing a novel interaction network that provides a baseline to identify the mechanism of action of the phytochemicals and molecular mechanism of synergy. The above findings have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals). …”
Get full text

Improved life cycle assessment for desalination : handling the choices and uncertainties by Zhou, Jin

“…The system boundary and characterization approach was selected based on our previous findings. This work provided the environment profile of Singapore’s desalinations with improved reliability. …”
Get full text

Occurrence, human exposure and dynamics of phthalates in ACMV indoor environments : method development and field studies by Chen, Ailu

“…The increases are because of either resuspension of phthalates bound to settled dust or partitioning of gas-phase phthalates to the airborne particles. The findings also demonstrate that the gas fractions of the low-volatile phthalates decrease when the airborne particle concentrations increase.…”
Get full text

先秦思想中音乐与情感的关系 ：以《孟子》《庄子》“乐”（lè）与 “乐” （yuè）的运用为核心 = The relations between music and emotion in Pre-Qin thought : an analysis of the usage of ‘Lè’ and ‘Yuè’ in the Mencius and the Zh... by 何昱慧 Ho, Adeline Yu Hui

“…Understanding the relations between“乐” and Music and Emotions in Pre-Qin text are necessary in finding the underlying significance. On the other hand, it also helps in the analysis of ideology promoted to shape the society at that point of time, which is beneficial to the progress of research in the topic.…”
Get full text

新加坡当代社会同志自由的研究 = A study of homosexuals’ liberty in present day Singapore by 陈惠嫔 Tan, Mabel Hui Ping

“…Analysis of credible survey results and reports, as well as gathering personal anecdotes and surveys from respondents was done. Findings were analyzed in an attempt to understand and explain how the tension between the individuals and society at large works. …”
Get full text

Aircraft noise, overheating and poor air quality in London primary schools' classrooms by Montazami, Azadeh

“…It is shown in this study that overheating and air quality benchmarks which are proposed by 'Department for Education and Skills' in Building Bulletin 101 and used to design and refurbish the UK schools, are relaxed benchmarks in comparison with the others which are proposed by different organisations and researchers. The overall findings of this thesis have been developed to draw the attention of school designers' to the current and future potential conflicts between the comfort factors in schools' classrooms. …”
Get full text

Neuronal control of cardiac excitability in pro-hypertensive states by Larsen, H

“…</p> <p><b>Chapter 7</b> forms the concluding discussion that summarises the main findings of this thesis and attempt to place it in a clinical context, and highlights avenues of further research. …”

Outcomes of shoulder replacement surgery in routine care by Craig, RS

“…The available studies were of low quality and produced few reliable findings to inform practice. RCTs provided very little useful data on the rates of revision surgery and adverse events. …”