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Discovery of COVID-19 protein inhibitors in phenolic acids of azadirachta indica (neem) using docking and pharmacokinetics
Published 2024“…The most attractive antiviral targets of SARS-CoV-2 are the spike protein and main protease (Mpro). In this work, sixteen phenolic acids of Azadirachta indica were docked into the active site of the spike protein and Mpro. …”
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Article -
165
B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination
Published 2022“…Infection generates a broad distribution of SARS-CoV-2-specific clones predicted to target the spike protein, while a more focused response after vaccination mainly targets the spike's receptor-binding domain. …”
Journal article -
166
Finite rate Innovation and its applications in electrocardiography
Published 2015Get full text
Thesis -
167
Improved margin multi-class classification using dendritic neurons with morphological learning
Published 2015“…We present an architecture of a spike based multiclass classifier using neurons with non-linear dendrites and sparse synaptic connectivity where each synapse takes a binary value. …”
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Conference Paper -
168
Seroprevalence of SARS-CoV-2 in children and adolescents
Published 2023“…The results showed a high prevalence of pre-existing immunity against seasonal coronaviruses when measuring IgG concentration of antibodies against spike protein but did not confer protection against SARS-CoV-2.…”
Thesis -
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Numerical modelling of detonation reaction zone of nitromethane by EXPLO5 code and wood and kirkwood theory
Published 2021“…The measured particle velocity profile of NM shows the existence of a sharp spike followed by a rapid drop over the first 5-10 ns (fast reaction). …”
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Journal Article -
171
Modeling distance-dependent individual head-related transfer functions in the horizontal plane using frontal projection headphones
Published 2016“…Soc. 61, 989–1000] project the sound directly onto the pinnae from the front, and thus inherently create listener's idiosyncratic pinna cues at the eardrum. …”
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Journal Article -
172
Creating a visual music interface via emotion detection
Published 2010Get full text
Final Year Project (FYP) -
173
Investigating viral glycosylation pathways for drug and vaccine development
Published 2021“…Chapter 4 focuses on the site-specific glycosylation occupancy, and N- and O-glycan structures attached to virion derived SARS-CoV-2 spike glycoproteins. This glycan signature was compared to a stabilised prefusion trimeric spike, to a monomeric subunit of spike (S1) and to an antigen of a non-stabilised vaccine candidate, revealing subunit shedding of the S1 glycoprotein for the vaccine candidate. …”
Thesis -
174
Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability
Published 2023“…However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. …”
Journal article -
175
Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations
Published 2023“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
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Journal Article -
176
Single antenna power measurements based direction finding : an FRI solution
Published 2010Get full text
Final Year Project (FYP) -
177
Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1)
Published 2024“…Results: We found significantly lower fold change in serum binding IgA responses against BA.1, BA.5 and EG.5.1 spike in the bivalent booster group, compared with the monovalent (WT) booster group, following vaccination. …”
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Journal Article -
178
Towards a computer that functions like the human brain
Published 2022“…Spike-Timing-Dependent Plasticity and unsupervised learning in the network is researched in this report. …”
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Final Year Project (FYP) -
179
Synaptic CMOS transistor
Published 2020“…In this work, electrical measurements were conducted on commercial level TiN/HfO2 gated n-channel MOSFET transistor (with an equivalent oxide thickness of 1.7nm) to demonstrate that it can exhibit some critical synaptic characteristics of a biological synapse such as excitatory and inhibitory postsynaptic current (EPSC and IPSC), short-term plasticity (STP) and long-term potentiation (LTP), metaplasticity, and spike timing dependent plasticity (STDP). The mechanism behind the output characteristic of MOSFET to exhibit synaptic-like response is the charge trapping and de-trapping at defects in the oxide and oxide/semiconductor interface. …”
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Final Year Project (FYP) -
180
A scalable variational inference approach for increased mixed-model association power
Published 2025“…We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. …”
Journal article