Crosslinked microneedle patch to extract interstitial fluid for diagnosis by Kang, Rong Jie

“…In this study, we have successfully developed a hydrogel microneedle based on hyaluronic acid derivative (methylcrylate modified hyaluronic acid, MeHA) and demonstrated its superior mechanical strength; having approximate 8 times the strength required for penetration into the skin. It was successfully penetrated into porcine cadaver skin, as well as the skin of a live mouse. …”
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Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
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A two-stage automatic color thresholding technique by Pootheri, Shamna, Ellam, Daniel, Grübl, Thomas, Liu, Yang

“…The segmentation of skin cancer lesions will help doctors to automate skin cancer detection. …”
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Is clicking mechanism good for flapping wing micro aerial vehicle? by Chin, Yao Wei, Lau, Gih Keong

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Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…Results: We found significantly lower fold change in serum binding IgA responses against BA.1, BA.5 and EG.5.1 spike in the bivalent booster group, compared with the monovalent (WT) booster group, following vaccination. …”
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Towards a computer that functions like the human brain by Lee, Seow Wei

“…Spike-Timing-Dependent Plasticity and unsupervised learning in the network is researched in this report. …”
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Free vibration properties of beetle elytron plate: Composite material, stacked structure and boundary conditions by Song, Yiheng, Hao, Ning, Ruan, Sihan, He, Chaochao, Quanjin, Ma

“…The results indicate that 1) the ranking of structural parameters on the 1st order frequency from a strong to weak sequence is as follows: length-to-width ratio, core height-to-thickness ratio, foam density and skin thickness; for the 2nd order natural frequency: length-to-width ratio, skin thickness, foam density and core height-to-thickness ratio. 2) Generally, an increase in the length-to-width ratio will reduce the frequency of the BEP, and increases in the core height-to-thickness ratio and skin thickness will raise its frequency. …”
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What does acne genetics teach us about disease pathogenesis? by Common, J. E. A., Barker, J. N., van Steensel, Maurice A. M.

“…Background: Acne vulgaris is a highly prevalent inflammatory skin disorder with a complex pathogenesis, characterized by comedones, papules, pustules and nodules. …”
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Infection patterns of scabies and tinea between inland and resettled indigenous Negrito communities in peninsular Malaysia by Er, Yi Xian, Than, Leslie Thian Lung, Muslim, Azdayanti, Yap, Nan Jiun, Tee, Mian Zi, Abdull-Majid, Nurmanisha, Lee, Soo Ching, Shahrizal, Shezryna, Lim, Yvonne Ai Lian

“…Skin infections cause significant health burden and affect underserved communities such as the indigenous Negrito communities disproportionately. …”
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Experimental and numerical investigations of hot-rolled stainless steel channel section columns susceptible to flexural buckling by Li, Shuai, Zhang, Lulu, Liang, Yating, Zhao, Ou

“…A thorough testing and numerical modelling programme has been conducted to investigate the minor-axis flexural buckling behaviour and resistances of pin-ended hot-rolled stainless steel channel section columns. …”
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Measuring membrane capacitance during a depolarizing stimulus by Chen, Peng., Gillis, Kevin., Xue, Renhao., Pui, Tze Sian.

“…It is critical to resolve the highly dynamic kinetic steps along the molecular cascade of exocytosis in order to pin down the specific actions of regulatory molecules and eventually decipher this complex and fundamental process.…”
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Identification of proteins and genes as potential biomarkers in brown-marbled grouper (Epinephelus fuscoguttatus forsskal) resistance to Vibrio sp by Low, Chen Fei

“…Skin lesion specimens observed under the scanning electron microscope revealed disintegration of skin around the lesion, and presence of bacterial cells under high magnification of 6000X. …”
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Understanding the implications of engineered nanoparticle induced autophagy in human epidermal keratinocytes in vitro by Gautam, Archana, Rakshit, Moumita, Nguyen, Kim Truc, Kathawala, Mustafa Hussain, Nguyen, Luong Thi Hien, Tay, Chor Yong, Wong, Esther, Ng, Kee Woei

“…While toxicological risks of applying these materials are generally regarded as low due to minute levels of penetration across the skin, our understanding of the physiological influence of potential cell-nanoparticle interactions in the skin is limited. …”
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Effect of Z19n, a synthetic compound, on Cutibacterium acnes growth and biofilm by Choo, Ying

“…As a chronic inflammatory skin disease of the pilosebaceous units and one of the most common skin disorders in the world, acne has affected 88% of adolescents aged 13-19 in Singapore.[1] Treatment for acne is the use of antibiotics. …”
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Effects of various surface treatments on the storage life of guava (Psidium guajava L) at 10°C by Mohamed, Suhaila, Kyi, Khin Ma Ma, Yusof, Salmah

“…Paraffin treatment caused the skin to turn brown after 2 weeks storage. The ascorbic acid content was highest in control followed by clingwrapped guava. …”

Synaptic CMOS transistor by Chai, Zhen Hong

“…In this work, electrical measurements were conducted on commercial level TiN/HfO2 gated n-channel MOSFET transistor (with an equivalent oxide thickness of 1.7nm) to demonstrate that it can exhibit some critical synaptic characteristics of a biological synapse such as excitatory and inhibitory postsynaptic current (EPSC and IPSC), short-term plasticity (STP) and long-term potentiation (LTP), metaplasticity, and spike timing dependent plasticity (STDP). The mechanism behind the output characteristic of MOSFET to exhibit synaptic-like response is the charge trapping and de-trapping at defects in the oxide and oxide/semiconductor interface. …”
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A scalable variational inference approach for increased mixed-model association power by Loya, H, Kalantzis, G, Cooper, F, Palamara, PF

“…We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. …”

Development of a counter-UAV system by Tang, Wen Yue

“…Upon testing, the firing pin mechanism was found to be unable to reliably puncture the CO2 canister, even after improvements. …”
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Monitoring and alerting system for epilepsy patients by Amandis Singh Dhillon

“…The developed system makes uses of a galvanic skin response (GSR) sensor, heart rate sensor and the surrounding Pollutant Standard Index (PSI) to determine the stress level of the patient. …”
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Transmucosal insulin delivery by Muhammad Qadhin Ahmad

“…Most research on ultrasound-induced drug transport enhancement focus on the use of low-frequency ultrasound (<100 kHz) and skin tissue as the membrane of choice. However, the argument against using skin is its low passive permeability. …”
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