A scalable variational inference approach for increased mixed-model association power by Loya, H, Kalantzis, G, Cooper, F, Palamara, PF

“…We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. …”

Development of a counter-UAV system by Tang, Wen Yue

“…Upon testing, the firing pin mechanism was found to be unable to reliably puncture the CO2 canister, even after improvements. …”
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Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains by Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer-van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, Matthews, Paul M.

“…To delineate the pathological correlations of distinct lipid species, we conducted a comprehensive characterization of both spatially localized and global differences in brain lipid composition in AppNL-G-F mice with spatial and bulk mass spectrometry lipidomic profiling, using human amyloid-expressing (h-Aβ) and WT mouse brains controls. …”
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Enhanced restoration of visual code after targeting ON bipolar cells compared to retinal ganglion cells with optogenetic therapy by Rogers, J, Hughes, S, Ebrahimi, A, Allen, A, Storchi, R, Lindner, M, Peirson, S, Badea, T, Hankins, M, Lucas, R

“…Our data show that, while both approaches restore visual responses with impressive fidelity, ON BC targeting produces a richer visual code closer to that of wild-type mice. …”

Strong immune responses and robust protection following a novel protein in adjuvant tuberculosis vaccine candidate by Korompis, M, De Voss, CJ, Li, S, Richard, A, Almujri, SS, Ateere, A, Frank, G, Lemoine, C, McShane, H, Stylianou, E

“…Vaccinated mice had enriched lung parenchymal antigen-specific CD4 + CXCR3 + KLRG1− T cells previously associated with TB protection. …”

Lessons from a retrospective look at India’s upstream sector by Elango, P

Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

“…Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell-selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. …”
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Dengue death rate higher among women than men in Bangladesh by Roney, Miah, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Given the atypical seasonality of the epidemic and the sudden spike in cases early on, it is noteworthy that mosquito and potential hotspot densities were at an all-time high throughout the previous years.…”
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Design and development of extreme learning machine symposium web portal by Chiang, Yu Hui.

“…In recent years, it has been observed that there is a spike in interest in the development of web based conference management systems. …”
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Mean-field approximation for networks with synchrony-driven adaptive coupling by Fennelly, N, Neff, A, Lambiotte, R, Keane, A, Byrne, A

“…In place of the less tractable spike-timing-dependent plasticity, we employ recently validated phase-difference-dependent plasticity rules, which adjust coupling strengths based on the relative phases of θ-neuron oscillators. …”

中朝古代桃花源文学比较研究 = A comparative study of peach blossom literature in ancient China and Korea by 蔡佳敏 Cai, Jiamin

“…This peach blossom imagery develops from Tao Yuan Ming's portrayal of a peach blossom in his famous poetry "The Peach Colony" ("Tao Hua Yuan Shi with Ji"). …”
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Sympathetic-neuron-derived neuropeptide Y (NPY) regulates adipose tissue immunometabolic homeostasis by Zhu, Y

“…This defect is replicated in conditional knockout (cKO) mice with NPY specifically abrogated from sympathetic neurons. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…The results show that Hif-1α protein and HIF targets were upregulated in left ventricular tissue of α-MHC719/+ mice. Cardiomyocyte-specific abolishment of Hif-1a blunted the disease phenotype, as evidenced by decreased left ventricular wall thickness, reduced myocardial fibrosis, disordered SRX/DRX state and ROS production. cHif1aKO induced normalization of pro-hypertrophic and pro-fibrotic left ventricular remodeling signaling evidenced on whole transcriptome and proteomics analysis in α-MHC719/+ mice. …”

Cross-modal size-contrast illusion : acoustic increases in intensity and bandwidth modulate haptic representation of object size by Uesaki, Maiko, Ashida, Hiroshi, Kitaoka, Akiyoshi, Pasqualotto, Achille

“…In this study, a series of images each comprising a pair of pine-tree figures were translated into auditory modality using sensory substitution software. …”
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Structural performance of recycled aggregate concrete-filled stainless steel tube columns by Tan, Chia Wei

“…The experiment involved 12 RACFSST columns tested under pin-ended condition, as well as material tests and initial global geometric imperfection measurements. …”
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Design and 3D printing of reconfigurable structures by Teo, Ee Hian

“…The structure is made up of single modular units being repeatedly fixed together, this leads to the structure to isolate single modular units that are damaged, allowing it to be easily pin-pointed and replaced by fabricating another similar single unit, this cut cost as the structure can be salvaged by replacing a single unit instead of the whole structure.…”
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Tie the knot - a step by step wedding planner by Alex Arvin S Susaipillai

“…The creation comprises essential management tools such as wedding checklist, reminders, budget tracker, guestlist, online electronic invitation and RSVP system with SMS function, seating plan, calendar function, vendor list, pin board, wedding day scheduler and chat function…”
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Self-quenched semiconducting polymer nanoparticles for amplified in vivo photoacoustic imaging by Xie, Chen, Upputuri, Paul Kumar, Zhen, Xu, Pramanik, Manojit, Pu, Kanyi

“…By virtue of the targeting capability of cyclic-RGD, the amplified SPN can effectively delineate tumor in living mice and increase the PA intensity of tumor by 4.7-fold after systemic administration. …”
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Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis by Ma, J

“…</p> <p>By monitoring the spontaneous tumour formation in mice, it was found that a lack of FIH expression does not profoundly affect the lifespan but accelerates the development of low-grade B cell lymphomas. …”

MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress by Rodrigues, B, Leitão, RA, Santos, M, Trofimov, A, Silva, M, Inácio, ÂS, Abreu, M, Nobre, RJ, Costa, J, Cardoso, AL, Milosevic, I, Peça, J, Oliveiros, B, Pereira de Almeida, L, Pinheiro, PS, Carvalho, AL

“…Additionally, viral overexpression of miR-186-5p in the PFC of naïve mice induces anxiety- and depressive-like behaviours. …”