Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination by das Neves, SP, Delivanoglou, N, Ren, Y, Cucuzza, CS, Makuch, M, Almeida, F, Sanchez, G, Barber, MJ, Rego, S, Schrader, R, Faroqi, AH, Thomas, J-L, McLean, PJ, Oliveira, TG, Irani, SR, Piehl, F, Da Mesquita, S

“…Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in mature oligodendrocyte numbers and specific lipid species in the brain. …”

Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
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Chromatin laser imaging reveals abnormal nuclear changes for early cancer detection by Chen, Yu-Cheng, Chen, Qiushu, Tan, Xiaotain, Chen, Grace, Bergin, Ingrid, Muhammad Nadeem Aslam, Fan, Xudong

“…By imaging the lasing emissions from chromatins, we discovered that, despite the absence of observable lesions, polyps, or tumors under stereoscope, high-fat mice exhibited significantly lower lasing thresholds than low-fat mice. …”
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The critical role of IL-23 receptor positive T cells in the pathogenesis of anterior uveitis associated with spondyloarthropathy by Hedley, R

“…</p> <p>Recently, systemic overexpression of IL-23 in mice has shown the accumulation of a small number of γδ T cells proximal to the anterior uvea. …”

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…Results: We found significantly lower fold change in serum binding IgA responses against BA.1, BA.5 and EG.5.1 spike in the bivalent booster group, compared with the monovalent (WT) booster group, following vaccination. …”
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Towards a computer that functions like the human brain by Lee, Seow Wei

“…Spike-Timing-Dependent Plasticity and unsupervised learning in the network is researched in this report. …”
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Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling by Vinaiphat, Arada, Pazhanchamy, Kalailingam, JebaMercy, Gnanasekaran, Ngan, SoFong Cam, Leow, Melvin Khee-Shing, Ho, Hee Hwa, Gao, Yong-Gui, Lim, Kah-Leong, Richards, A. Mark, de Kleijn, Dominique P. V., Chen, Christopher P., Kalaria, Raj N., Liu, Jian, O'Leary, Deborah D., McCarthy, Neil E., Sze, Siu Kwan

“…Altered protein expression in hypertensive compared to normal mice was characterized by liquid chromatography tandem mass spectrometry. …”
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Experimental and numerical investigations of hot-rolled stainless steel channel section columns susceptible to flexural buckling by Li, Shuai, Zhang, Lulu, Liang, Yating, Zhao, Ou

“…A thorough testing and numerical modelling programme has been conducted to investigate the minor-axis flexural buckling behaviour and resistances of pin-ended hot-rolled stainless steel channel section columns. …”
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Modeling the proactive driving behavior of connected vehicles : a cell-based simulation approach by Zhu, Feng, Ukkusuri, Satish V.

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Functional characterization of orexin system by Chua, Peiling

“…Also, currently there is an absence of a good behavioral paradigm which mimics major depression so we hope to develop one by applying chronic stress through forced swimming test, together with clomipramine, to male wild-type mice. However, the results were not on par with our assumptions as we presumed that the mice will develop depression-like symptoms after 7 days of treatment and we also did not manage to generate the viral vectors. …”
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Focused array analysis of diabetic skin wound. by Ling, Wei Yin.

“…To understand the interplay among these players behind angiogenesis and discover possible therapeutic targets, a focused array approach employing real-time quantitative PCR technique was used to unravel the differential gene molecular profiles in the healing of chronic diabetic mice wounds compared to that of normal wounds. In vivo analyses using wildtype (+/+) and diabetic (ob/ob) mice wounds revealed many angiogenic factors and inflammatory mediators with altered gene expression patterns and levels leading to the chronic inflamed state of diabetic wounds. …”
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In vivo visualization of cells with fluorescent-labeled fab fragment. by Wee, Armanda Lixuan.

“…However, the current use of fluorescent reporter mice and fluorescent-labeled antibodies are accompanied with several limitations that restricts their usefulness for in vivo imaging. …”
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Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome by Alford, KA, Slender, A, Vanes, L, Li, Z, Fisher, EMC, Nizetic, D, Orkin, SH, Roberts, I, Tybulewicz, VLJ

“…We show that although Tc1 mice do not develop leukemia, they have macrocytic anemia and increased extramedullary hematopoiesis. …”

Wearable bio-adhesive metal detector array (BioMDA) for spinal implants

“…Accordingly, herein, we report on the development and engineering of a bio-adhesive metal detector array (BioMDA), a potential wearable solution for real-time, non-invasive positional analyses of osseous implants within the spine. The electromagnetic coupling mechanism and intimate interfacial adhesion enable the precise sensing of the metallic implants position without the use of radiation. …”
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Deep learning approach to cervical segmentation from routine CT images by Duan, Yiming

“…To address the sequential and location-dependent nature of bone segmen tation information, the dissertation proposes a pre-training model for location information, and combines 2.5D image input and labeled multi-channel coding to semantically segment 3D cervical spine CT images. This method can accu rately extract the information of bone joint location of slices and incorporate it into image features in the form of channels, which can improve the accuracy of multiple bone joint segmentation and classification. …”
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Measuring membrane capacitance during a depolarizing stimulus by Chen, Peng., Gillis, Kevin., Xue, Renhao., Pui, Tze Sian.

“…It is critical to resolve the highly dynamic kinetic steps along the molecular cascade of exocytosis in order to pin down the specific actions of regulatory molecules and eventually decipher this complex and fundamental process.…”
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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Increased Fgf21 expression was observed in liver of PPARβ/δ-null mice and in mouse primary hepatocytes when this receptor was knocked down by small interfering RNA (siRNA). …”
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The role of calcium dependent neurotransmission in axon path finding, myelination and maintenance of specified cortical projection neuron populations by Korrell, K

“…</p> <p>Together, the results indicate that neuronal activity has little effect on the onset of myelination but has effects on the g-ratio in deep cortical layer projection neurons in mice.</p>…”

The response of Pinus caribaea mor. var. Hondurensis seedlings to nitrogen, phosphorous and potassium fertilizers by Srivastava, P.B.L., Naruddin, Abang, Zainorin, B.Abang

“…For this purpose, seedlings were grown in plastic pots in soils collected from Bahau pine experimental area. These soils belong to Durian series and are generally poor in nutrients. …”
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Synaptic CMOS transistor by Chai, Zhen Hong

“…In this work, electrical measurements were conducted on commercial level TiN/HfO2 gated n-channel MOSFET transistor (with an equivalent oxide thickness of 1.7nm) to demonstrate that it can exhibit some critical synaptic characteristics of a biological synapse such as excitatory and inhibitory postsynaptic current (EPSC and IPSC), short-term plasticity (STP) and long-term potentiation (LTP), metaplasticity, and spike timing dependent plasticity (STDP). The mechanism behind the output characteristic of MOSFET to exhibit synaptic-like response is the charge trapping and de-trapping at defects in the oxide and oxide/semiconductor interface. …”
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