PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. Results The PPARβ/δ agonist GW501516 prevented lipid-induced ER stress in mouse and human myotubes and in skeletal muscle of mice fed a high-fat diet. …”
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Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…Notably, when the IB-treated mice were subsequently re-challenged with CT26 cells, the immune mediated-response prevented the establishment of a second tumor in the mice. …”
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Hybrid biometric authentication for automatic teller machine by Arokiasamy, Steven R., Tomal, Md Raihanul Islam, Moorthy, Kohbalan, Mohd Daud, Kauthar

“…Unlike traditional password or PIN-based methods, biometric authentication uses unique physical characteristics, such as fingerprints, to verify identity. …”
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Security enhancement for domain name system in the internet by Narayanan Arjun

“…Domain Name System (DNS) can be referred as the spine of today’s Internet world. This system is completely responsible for providing an architecture that helps in resolving millions of domain names existing throughout the world to a unique IP address, enabling the users to access the domains from anywhere on the planet. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Chapter 4 focuses on the site-specific glycosylation occupancy, and N- and O-glycan structures attached to virion derived SARS-CoV-2 spike glycoproteins. This glycan signature was compared to a stabilised prefusion trimeric spike, to a monomeric subunit of spike (S1) and to an antigen of a non-stabilised vaccine candidate, revealing subunit shedding of the S1 glycoprotein for the vaccine candidate. …”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. …”

Design of a dual band planar inverted-F antenna for GMS/DCS mobile handset by Fang, Jun

“…This project involved the study of size miniaturization of microstrip antenna techniques: shorting pin and shorting wall, loading, shorted spiral printed antenna and stacked shorted patch antenna are fully discussed.…”
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Study on the wear characteristics of aluminium metal matrix composite with 15% Al2O3 and 20% Al2O3 by Chua, Swu Chun.

“…The objective of this dissertation was to study the wear characteristics and behaviour of aluminium metal matrix composite materials (MMCs), namely Duralcan 286 and Duralcan 284 as a pin material when mated against three types of dics materials.…”
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OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy by Zeng, Yong, Gao, Shasha, Li, Yichao, Marangoni, Dario, De Silva, Tharindu, Wong, Wai T., Chew, Emily Y., Sun, Xun, Li, Tiansen, Sieving, Paul A., Qian, Haohua

“…Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. …”
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Microcrystalline Tyrosine (MCT®): a depot adjuvant in licensed allergy immunotherapy offers new opportunities in malaria by Cabral-Miranda, G, Heath, MD, Gomes, AC, Mohsen, MO, Montoya-Diaz, E, Salman, AM, Atcheson, E, Skinner, MA, Kramer, MF, Reyes-Sandoval, A, Bachmann, MF

“…Both MCT and Alum strongly increased immunogenicity of CSP compared to PBS in both C57BL/6 and BALB/c mice. Challenge studies in mice using a chimeric <em>P. bergei</em> expressing CSP of <em>P. vivax</em> demonstrated clinically improved symptoms of malaria with CSP formulated in both MCT and Alum; protection was, however, more pronounced if CSP was formulated in MCT. …”

Design of an exoskeleton for lifting by Lim, Ernest Zhen Xuan

“…Lower back injuries, caused by muscle strain around the lumber spine, are common in work involving manual labour. …”
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Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination by das Neves, SP, Delivanoglou, N, Ren, Y, Cucuzza, CS, Makuch, M, Almeida, F, Sanchez, G, Barber, MJ, Rego, S, Schrader, R, Faroqi, AH, Thomas, J-L, McLean, PJ, Oliveira, TG, Irani, SR, Piehl, F, Da Mesquita, S

“…Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in mature oligodendrocyte numbers and specific lipid species in the brain. …”

Multiscale topological indices for the quantitative prediction of SARS CoV-2 binding affinity change upon mutations by Bi, Jialin, Wee, JunJie, Liu, Xiang, Qu, Cunquan, Wang, Guanghui, Xia, Kelin

“…Biologically, protein-protein interactions between SARS-CoV-2 surface spike (S) protein and human ACE2 protein are the key mechanism behind the COVID-19 disease. …”
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Chromatin laser imaging reveals abnormal nuclear changes for early cancer detection by Chen, Yu-Cheng, Chen, Qiushu, Tan, Xiaotain, Chen, Grace, Bergin, Ingrid, Muhammad Nadeem Aslam, Fan, Xudong

“…By imaging the lasing emissions from chromatins, we discovered that, despite the absence of observable lesions, polyps, or tumors under stereoscope, high-fat mice exhibited significantly lower lasing thresholds than low-fat mice. …”
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The critical role of IL-23 receptor positive T cells in the pathogenesis of anterior uveitis associated with spondyloarthropathy by Hedley, R

“…</p> <p>Recently, systemic overexpression of IL-23 in mice has shown the accumulation of a small number of γδ T cells proximal to the anterior uvea. …”

Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…Results: We found significantly lower fold change in serum binding IgA responses against BA.1, BA.5 and EG.5.1 spike in the bivalent booster group, compared with the monovalent (WT) booster group, following vaccination. …”
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Towards a computer that functions like the human brain by Lee, Seow Wei

“…Spike-Timing-Dependent Plasticity and unsupervised learning in the network is researched in this report. …”
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Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling by Vinaiphat, Arada, Pazhanchamy, Kalailingam, JebaMercy, Gnanasekaran, Ngan, SoFong Cam, Leow, Melvin Khee-Shing, Ho, Hee Hwa, Gao, Yong-Gui, Lim, Kah-Leong, Richards, A. Mark, de Kleijn, Dominique P. V., Chen, Christopher P., Kalaria, Raj N., Liu, Jian, O'Leary, Deborah D., McCarthy, Neil E., Sze, Siu Kwan

“…Altered protein expression in hypertensive compared to normal mice was characterized by liquid chromatography tandem mass spectrometry. …”
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Experimental and numerical investigations of hot-rolled stainless steel channel section columns susceptible to flexural buckling by Li, Shuai, Zhang, Lulu, Liang, Yating, Zhao, Ou

“…A thorough testing and numerical modelling programme has been conducted to investigate the minor-axis flexural buckling behaviour and resistances of pin-ended hot-rolled stainless steel channel section columns. …”
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Modeling the proactive driving behavior of connected vehicles : a cell-based simulation approach by Zhu, Feng, Ukkusuri, Satish V.

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