SARS-CoV-2 evolution during treatment of chronic infection by Kemp, SA, Collier, DA, Datir, RP, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, IU, Roberts, DJ, Chandra, A, Temperton, N, Sharrocks, K, Blane, E, Modis, Y, Leigh, KE, Briggs, JAG, van Gils, MJ, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK

“…The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. …”

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St., Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Sequential immunization of mice with DNA-based VLPs (DNA-VLPs) elicits protective neutralizing antibodies to SARS-CoV-2 in a manner that depends on the valency of the antigen displayed and on T cell help. …”
Get full text

A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…The relationship between spike antibody isotype, IgG subclass, glycosylation and functional responses, and the relationship between these properties and protection, was explored. …”

Existence and Analysis of a Rotating Stall Inception Continuum & Development of Concept Questions in Fluid Dynamics by Cherry, Maranda F.

“…The divergence of stall inception from two-dimensionality is suggested as a distinguishing feature of spike type stall inception compared to modal type stall inception. …”
Get full text

Characterization of cell types and connectivity of the deep cerebellar nuclei by Lim, Zoe Hui

“…Taken together, our results indicate that direct projections from the cerebellum to hippocampus and hypothalamus exist in mice and we have begun to characterize the cells from which these connections may arise.…”
Get full text

Stress faced by executives in Singapore. by Par, Hwee Fong., Tan, Chin Ying., Thong, Hwei Ling.

Get full text

Challenges faced by women in the corporate world by Ang, Hui Jia, Sim, Jasmine Mei Yao, Yeo, Siew Hong

Get full text

Fabrication of heat sinks by Selective Laser Melting for convective heat transfer applications by Wong, Kin Keong, Ho, Jin Yao, Leong, Kai Choong, Wong, Teck Neng

“…Three heat sinks comprising pin fins of circular, rectangular-rounded and aerofoil geometries were fabricated by SLM from aluminium alloy AlSi10Mg powder. …”
Get full text

Comparative study of accounting standards between Singapore and the Peoples' Republic of China by Neo, Karn Nee, Siew, May San, Swi, Li Li

Get full text

Behavioural and biochemical abnormalities in a mouse model for Parkinson's disease. by Ten, Rachel Rui Xian.

“…There were no statistical differences in anxiety and depression-like behaviour between the non-transgenic and transgenic mice. These results were concomitant with good motor performance in both mice groups, though, contrary to published literature, motor deficits were not found in older (6 months old) mice. …”
Get full text

Convective boiling and condensation in enhanced tubes produced by selective laser melting by Tan, Choon Yong

“…The design of the four tubes are five long circumferential pin fins, eight short circumferential pin fins, twisted pin fins and a metallic foam structure. …”
Get full text

Interferon-γ- and glucocorticoid-mediated pathways synergize to enhance death of CD4(+) CD8(+) thymocytes during Salmonella enterica serovar Typhimurium infection by Deobagkar-Lele, M, Chacko, SK, Victor, ES, Kadthur, JC, Nandi, D

“…Upon infection, Ifnγ(-/-) mice display higher CFU and lower survival but more surviving thymocytes are recovered. …”

Serotonin transporter function and emotional behaviour by Lima, J

“…Moreover, 5-HTTKO mice exhibited superior aversive learning via augmented BLA function. …”

Roles of leucine-rich alpha-2-glycoprotein 1 in normal and diabetic wound healing by Liu, Chenghao

“…Western blot analysis shows reduced formation of neutrophil extracellular traps in the wounds of diabetic Lrg1-/- mice. Neutrophils isolated from Lrg1-/- mice are less susceptible to inducer of ΝΕΤs formation. …”
Get full text
Get full text

A two-dimensional co-rotational Timoshenko beam element with XFEM formulation by Xu, Jin, Lee, Chi King, Tan, Kang Hai

“…Pin connections and plastic hinges produce non-smooth displacement fields in beam structures. …”
Get full text
Get full text

Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y., Poh, Luting, Jo, Dong-Gyu, Herr, Deron R., Zhang, Shenpeng R., Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K. P., Chen, Christopher Li- Hsian, Drummond, Grant R., Lim, Kah-Leong, Sobey, Christopher G., Arumugam, Thiruma V.

“…However, BCAS-induced changes in hippocampal gene expression differed between young and aged mice. Specifically, transcriptomic analysis indicated that in comparison to young sham mice, many pathways altered by BCAS in young mice resembled those already present in sham aged mice. …”
Get full text

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping by Tir, S, Foster, RG, Peirson, SN

“…Home cage activity in C57BL/6J mice was recorded under a range of lighting conditions, along with circadian clock-deficient cryptochrome-deficient mice (Cry1−/−, Cry2−/− double knockout). …”

Study of heat transfer through micro-structured surfaces by Chin, Wei Hao

“…Each chip has a different microstructure in the form of very small and elongated pin-fins, which will in turn affect the critical heat flux of each component. …”
Get full text

Discovery of COVID-19 protein inhibitors in phenolic acids of azadirachta indica (neem) using docking and pharmacokinetics by Roney, Miah, Huq, AKM Moyeenul, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…The most attractive antiviral targets of SARS-CoV-2 are the spike protein and main protease (Mpro). In this work, sixteen phenolic acids of Azadirachta indica were docked into the active site of the spike protein and Mpro. …”
Get full text

B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination by Kotagiri, P, Mescia, F, Rae, WM, Bergamaschi, L, Tuong, ZK, Turner, L, Hunter, K, Gerber, PP, Hosmillo, M, Hess, C, Clatworthy, MR, Goodfellow, IG, Matheson, NJ, McKinney, EF, Wills, MR, Gupta, RK, Bradley, JR, Bashford-Rogers, RJM, Lyons, PA, Smith, KGC

“…Infection generates a broad distribution of SARS-CoV-2-specific clones predicted to target the spike protein, while a more focused response after vaccination mainly targets the spike's receptor-binding domain. …”