Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy by Goh, Wei Jiang, Lee, Choon Keong, Zou, Shui, Woon, Esther, Czarny, Bertrand, Pastorin, Giorgia

“…Here, we report a systematic approach pertaining to various loading methods of the chemotherapeutic drug doxorubicin into our CDNs and examine the differential cellular uptake of drug-loaded CDNs in cancerous (HeLa) and healthy (HEK293) cell lines. Lastly, we proved that the addition of doxorubicin-loaded CDNs to the HeLa and HEK293 co-cultures showed a clear discrimination toward cancer cells at the cellular level. …”
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Strontium isoscape of sub-Saharan Africa allows tracing origins of victims of the transatlantic slave trade by Wang, X, Bocksberger, G, Arandjelovic, M, Agbor, A, Angedakin, S, Aubert, F, Ayimisin, EA, Bailey, E, Barubiyo, D, Bessone, M, Bobe, R, Bonnet, M, Boucher, R, Brazzola, G, Brewer, S, Lee, KC, Carvalho, S, Chancellor, R, Cipoletta, C, Cohen, H, Copeland, SR, Corogenes, K, Costa, AM, Coupland, C, Neil, E

“…We demonstrate the efficacy of this Sr isoscape, in combination with other lines of evidence, to trace the African roots of individuals from historic slavery contexts, particularly those with highly radiogenic 87Sr/86Sr ratios uncommon in the African Diaspora. …”

Bitcoins in the Malaysian Economy by Miraz, Mahadi Hasan, Mohd Sharif, Kamal Imran, Hassan, Mohamad Ghozali, Ismail, Mohd Azril, Ahmad Mahyadin@Mahidin, Fariza

“…This study focused on individual facts and details, such as articles, reviews, forums, Malaysians brochure, business lines, and research reports. The study relies on secondary data. …”
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Development of differential optical absorption spectroscopy (DOAS) system for hazardous methane gas detection in the near infrared region by Khandaker, Sayma, Hasan, Md Mahmudul, Nurulain Nadhirah, Shaipizaman, Mohd Amir Shahlan, Mohd Aspar, Hadi, Manap

“…An in-depth examination of the absorption lines was conducted to determine the optimal wavelength for measurement. …”
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Hackathons as Participatory Design: Iterating Feminist Utopias by Hope, Alexis, D'Ignazio, Catherine, Hoy, Josephine, Michelson, Rebecca, Roberts, Jennifer, Krontiris, Kate, Zuckerman, Ethan

“…Key to our re-imagining of conventional innovation structures is a focus on experience design, where joy and play serve as key strategies to help people and institutions build relationships across lines of difference. We conclude with a discussion of design principles applicable not only to designers of events, but to social movement researchers and HCI scholars trying to address oppression through the design of technologies and socio-technical systems.…”
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Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors by Wang, Xuesong, Ray, Rashmi, Kratochvil, Sven, Melzi, Eleonora, Lin, Ying‐Cing, Giguere, Sophie, Xu, Liling, Warner, John, Cheon, Diane, Liguori, Alessia, Groschel, Bettina, Phelps, Nicole

“…We validate this technology with the rapid generation of three BCR KI lines expressing native human precursors, instead of computationally inferred germline sequences, to HIV broadly neutralizing antibodies. …”
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Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells by Wang, Ruoxi W., Viganò, Sonia, Ben-David, Uri, Amon, Angelika, Santaguida, Stefano

“…Inactivating NF‐κB abolishes NK cell‐mediated clearance of untransformed aneuploid cells. In cancer cell lines, NF‐κB upregulation also correlates with the degree of aneuploidy. …”
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How information about historic carbon emissions affects support for climate aid: evidence from a survey experiment by Charnysh, Volha, Kalow, Jared, Lieberman, Evan, Walk, Erin

“…However, in democratic countries such as the United States, it remains uncertain whether such messages can affect public opinion, especially across partisan lines. We conducted a pre-registered survey from a national online pool (N = 5,002) with a built-in experiment to evaluate the effectiveness of alternative communications strategies associated with historic carbon emissions in increasing support for climate aid. …”
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A novel low-crosstalk driveline based on spoof surface plasmon polaritons by Zhao, Shumin, Zhang, Hao Chi, Liu, Liangliang, Zhao, Jiahao, Yang, Cheng

“…By using traditional drivelines, for example, microstrip lines, the distance between adjacent drivelines should be large enough to reduce the multichannel coupling effects. …”
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Fullwave modeling of coplanar-waveguide discontinuities for applications in filter design and metamaterial characterization by Gao, Jing

“…Coplanar waveguide (CPW) has been finding wide applications in microwave integrated circuit (MIC) and monolithic microwave integrated circuit (MMIC) due to several advantages it offers over microstrip lines. Typical discontinuities characteristics are an integral part of practical circuit design. …”
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New techniques for automated architectural reconstruction from photographs by Werner, T, Zisserman, A

“…Second, we develop and refine a technique for piecewise planar model fitting involving sweeping polygonal primitives, and assess the performance of this technique. Third, lines at infinity are constructed from image correspondences and used to sweep planes in the principal directions. …”

Integrative taxonomy clarifies the evolution of a cryptic primate clade by van Elst, T, Sgarlata, GM, Schüßler, D, Tiley, GP, Poelstra, JW, Scheumann, M, Blanco, MB, Aleixo-Pais, IG, Rina Evasoa, M, Ganzhorn, JU, Goodman, SM, Hasiniaina, AF, Hending, D, Hohenlohe, PA, Ibouroi, MT, Iribar, A, Jan, F, Kappeler, PM, Le Pors, B, Manzi, S, Olivieri, G, Rakotonanahary, AN, Rakotondranary, SJ, Rakotondravony, R

“…Here we illustrate best practices for clarifying cryptic diversification processes by presenting an integrative framework that leverages multiple lines of evidence and taxon-informed cut-offs for species delimitation, while placing special emphasis on identifying patterns of isolation by distance. …”

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines by Stanslas, Johnson, Hagan, Damien J., Ellis, Michael J., Turner, Claire, Carmichael, James, Ward, Wynne, Hammonds, Timothy R., Stevens, Malcolm F. G.

“…The novel water-soluble agent dihydroindolizino[7,6,5-kl]acridinium chloride 14 has inhibitory activity in a panel of non-small-cell lung and breast tumor cell lines exceeding that of m-AMSA. The salt inhibited the release of minicircle products of kDNA confirming that disorganization of topoisomerase II partly underlies the activity of the compound. …”

Cellular reporter for inflammation. by Yuhanis Abdullah Sunny.

“…Currently, there are commercial green fluorescent protein (GFP) assays available for in vitro cell lines only. There are no in vivo systems that can report NF-B activation in hematopoietic stem cells. …”
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Laser surface treatment of 50CrMo4 steel by Chew, Han Xin

“…The speed of laser is significance in affecting the width and depth of the laser treated lines. When the speed is too high, the change is not visible, thus, the hardness test cannot be done on the cross section area.…”
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Database and Application Programming Interface Development for Rotational Spectroscopy by Cheung, Jasmine So Yee

“…A database of spectroscopic data serves as the foundation of the automation pipeline for assigning spectral lines to species. While there are existing databases available for use, we developed our custom database, named SAAGAdb, and an application programming interface (API) to access the database to fulfill the needs of SAAGA. …”
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Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study by Top, Siden, Vessières, Anne, Leong, Weng Kee, Lee, Shirley Hui Zhi

“…In vitro evaluation of these new compounds showed that some are selectively active against estrogen receptor (ER)-independent MDA-MB-231 breast cancer cell lines relative to ER-dependent MCF-7 breast cancer cells, suggesting that the compounds have a different biological target specific to MDA-MB-231 cells. …”
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An iGlu receptor antagonist and its simultaneous use with an anticancer drug for cancer therapy by Luo, Zhong, Li, Peizhou, Tan, Si Yu, Ang, Chung Yen, Nguyen, Kim Truc, Zhao, Yanli

“…In vitro studies on B16F10 and NIH3T3 cell lines revealed that the iGlu receptor antagonist L1 exhibited therapeutic as well as targeting effects. …”
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Investigating the content and function of stress-induced extracellular vesicles in colorectal cancer by Mason, J

“…Therefore, my DPhil focussed on investigating the potential pro-tumorigenic properties of these “switched” EVs in CRC cell lines in vitro and also assessing the composition of EVs in CRC patient plasma.…”

Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes by Selvaraju, Thilaga Rati

“…In this study, the effects of vitamin E when supplemented before (pre-treatment) and after (post-treatment) glutamate insult were elucidated in neuronal and astrocyte cell lines. The neuroprotective effect of TRF and α-TCP were investigated. …”
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