Comparative systems biology analysis to study the mode of action of the isothiocyanate compound iberin on pseudomonas aeruginosa by Givskov, Michael, Nielsen, Thomas E., Tolker-Nielsen, Tim, Tan, Sean Yang-Yi, Liu, Yang, Chua, Song Lin, Vejborg, Rebecca Munk, Jakobsen, Tim Holm, Chew, Su Chuen, Li, Yingying, Yang, Liang

“…Taken together, the findings suggest that the mode of QS inhibition in iberin is through downregulation of the Gac/Rsm QS network, which in turn leads to the repression of QS-regulated virulence factors, such as pyoverdine, chitinase, and protease IV. …”
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Assessing mentoring : a scoping review of mentoring assessment tools in internal medicine between 1990 and 2019 by Ng, Yong Xiang, Koh, Zachary Yong Keat, Yap, Hong Wei, Tay, Kuang Teck, Tan, Xiu Hui, Ong, Yun Ting, Tan, Lorraine Hui En, Chin, Annelissa Mien Chew, Toh, Ying Pin, Shivananda, Sushma, Compton, Scott, Mason, Stephen, Kanesvaran, Ravindran, Krishna, Lalit

“…A ‘split approach’ saw research members adopting either Braun and Clarke’s approach to thematic analysis or directed content analysis to independently evaluate the data and improve validity and objectivity of the findings. Results: 9662 abstracts were identified, 187 full-text articles reviewed, and 54 full-text articles included. …”
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Maximizing dissimilarity in resting state detects heterogeneous subtypes in healthy population associated with high substance use and problems in antisocial personality by Kashyap, Rajan, Bhattacharjee, Sagarika, Yeo, Thomas B. T., Chen, Annabel Shen-Hsing

“…Gender differences were also significant. Altogether the findings suggested that subtypes exist even in healthy control population, and comparison studies (case vs. control) need to be mindful of it.…”
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Monolayer tungsten disulfide in photonic environment : angle-resolved weak and strong light-matter coupling by Zhang, Xuewen, Wu, Lishu, Wang, Xu, He, Silin, Hu, Hanwei, Shi, Guangchao, Zhang, Xingwang, Shang, Jingzhi, Yu, Ting

“…By embedding 1L-WS2 into a dielectric microcavity, strong exciton-photon coupling results in the formation of lower and upper polariton branches with an appreciable Rabi splitting of 34 meV at room temperature, where the observed blueshift of the lower polariton branch is indicative of the enhanced polariton-polariton scattering. Our findings highlight the effect of dielectric environment on angle-resolved optical response of exciton-photon interactions in a two-dimensional semiconductor, which is helpful to develop practical TMD-based architectures for photonic and polaritonic applications. …”
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Graphdiyne/graphene heterostructure: a universal 2D scaffold anchoring monodispersed transition-metal phthalocyanines for selective and durable CO₂ electroreduction by Gu, Huoliang, Zhong, Lixiang, Shi, Guoshuai, Li, Jiaqiang, Yu, Ke, Li, Jiong, Zhang, Shuo, Zhu, Chenyuan, Chen, Shaohua, Yang, Chunlei, Kong, Ya, Chen, Chen, Li, Shuzhou, Zhang, Jin, Zhang, Liming

“…The usage of the GDY/G heterostructure as a scaffold can be further extended to other organometallic complexes beyond CoPc. Our findings lend credence to the prospect of the GDY/G hybrid contributing to the design of single-molecule dispersed CO2R catalysts for sustainable energy conversion.…”
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Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation by Wu, Zhuoran, Setyawati, Magdiel Inggrid, Lim, Hong Kit, Ng, Kee Woei, Tay, Chor Yong

“…Transcriptome profiling, bioinformatics analysis and siRNA gene knockdown experiments revealed the nuclear factor erythroid 2-related factor 2 (Nrf2) as the key modulator of the ZnO NP-induced drug resistance. Our findings suggest that a ROS-inducing ENM can emerge as a nano-stressor, capable of regulating the chemosensitivity of colon cancer cells.…”
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Super-resolution imaging of photogenerated charges on CdS/g-C₃N₄ heterojunctions and its correlation with photoactivity by Wu, Shuyang, Lee, Jinn-Kye, Lim, Pei Chong, Xu, Rong, Zhang, Zhengyang

“…The photoactive species (i.e., e- and h+) were found to be preferentially distributed at the two end segments of CdS nanorods and the edge boundaries of g-C3N4. Therefore, our findings shed more light on the charge distribution and photocatalytic heterogeneity of composite materials at the nanoscale. …”
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Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.

“…Modulation of DNA methylation patterns in the cortex of AL CCH mice was re-modelled and signs of reversal was observed in IF CCH mice across all three timepoints. Conclusions: These findings provide an understanding of how IF may protect the brain against damage caused by CCH and show promise in offering potential beneficial effects in mitigating the neuropathology and cognitive deficits in VaD.…”
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Parent-infant affect synchrony during social and solo play by Kidby, Sayaka, Neale, Dave, Wass, Sam, Leong, Victoria

“…While our sample was small and from a homogeneous population (e.g. white, highly educated parents), limiting the implications of the findings, these results demonstrate that maternal active engagement in playful interaction with her infant affords, increases, and extends infant positive affect and parent-infant positive affect synchrony, providing insights into how the social context modulates infants' affective experiences. …”
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2D-3D perovskite memristor with low energy consumption and high stability for neural morphology calculation by Sun, Kaixuan, Wang, Qingrui, Zhou, Long, Wang, Jingjuan, Chang, Jingjing, Guo, Rui, Tay, Beng Kang, Yan, Xiaobing

“…Moreover, this perovskite-based artificial synapse has ultra-low power consumption due to the switchable p-i-n structure in organic-inorganic halide perovskites. Our finding highlights the immense application potential of the 2D-3D perovskite memristor in the future neuromorphic computing system.…”
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LKAW: a robust watermarking method based on large kernel convolution and adaptive weight assignment by Zhang, Xiaorui, Jiang, Rui, Sun, Wei, Song, Aiguo, Wei, Xindong, Meng, Ruohan

“…Robust watermarking requires finding invariant features under multiple attacks to ensure correct extraction. …”
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Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing by Zha, Kangkang, Xiong, Yuan, Zhang, Wenqian, Tan, Meijun, Hu, Weixian, Lin, Ze, Cheng, Peng, Lu, Li, Cai, Kaiyong, Mi, Bobin, Feng, Qian, Zhao, Yanli, Liu, Guohui

“…This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.…”
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Topography-incorporated adjoint-state surface wave Traveltime tomography: method and a case study in Hawaii by Hao, Shijie, Chen, Jing, Xu, Mijian, Tong, Ping

“…Additionally, our model reveals a high-velocity anomaly to the South of Hualalai's summit, which may be related to a buried rift zone. Our findings further demonstrate that including topography can lead to a correction of up to 0.8% in the shear wave velocity model of Hawaii, an island spanning approximately 100 km with volcanoes reaching elevations exceeding 4 km.…”
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Electrocatalytic reduction of simulated industrial CO2 and CO mixtures: revising chronoamperometry to enable selective gas mixture reduction via cyclic voltammetry by Chen, Wen Qian, Foo, Cyrus Jit Loong, Ge, Liya, Veksha, Andrei, Chan, Wei Ping, Shen, Yafei, Lisak, Grzegorz

“…Meanwhile, the results underscored the dependency of performance enhancement on the scan rate of cycling, revealing plausible correlations with mass transfer and electrode surface dynamics. Furthermore, the findings indicated that the selectivity towards HCOOH and C2H4 is closely related to the CO2/CO ratios of gas sources. …”
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Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…The relative fold change in serum binding IgA response was more skewed towards WT over variant (BA.1, BA.5 or EG.5.1) spike in previously infected bivalent-booster-vaccinees, as compared with previously infected monovalent-(WT)-booster-vaccinees. Conclusion: The findings suggest imprinting of antibody responses that is shaped by the first vaccination (WT spike). …”
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Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy by Zhu, Caigang, Chen, Shuo, Chui, Christopher Hoe-Kong, Tan, Bien-Keem, Liu, Quan

“…Meanwhile, several physiologically relevant parameters including hemoglobin oxygenation, total hemoglobin concentration, and redox ratio indicators estimated from diffuse reflectance and autofluorescence spectra show distinctively different trends over time for nonviable and viable skin. Conclusions: These findings will be helpful to clinicians for making a precise judgment on flap viability. …”
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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Ethnic differences in knowledge, attitudes, and practices related to dietary salt intake and association with hypertension in Malaysia: a multi-centre cross-sectional study by Chia, Yook Chin, Ching, Siew Mooi, Chew, Ming Tsuey, Devaraj, Navin Kumar, Oui, Jethro Ee Keat, Lim, Hooi Min, Chew, Bee Nah, Mohamed, Mohazmi, Ooi, Pei Boon, Cheng, Maong Hui, Beh, Hooi Chin, Chung, Felicia Fei-Lei

“…Those who were unaware of the difference between salt and sodium and who reported not reading salt labels had higher odds of having elevated blood pressure. These findings demonstrate that while there is a suboptimal translation of salt knowledge into practice in Malaysia, with significant differences in KAP observed between ethnic groups, the potential of improving health outcomes by improving the clarity and awareness of salt labels is substantial. …”

Xunzi's concern for yu (desire) and ritual approaches for its moral transformation by Zhou,Yalin

“…One’s pleasure-based liking is not merely painted by joy but a configuration of the more variable affective experiences, including the feeling of an 安 (security; at ease) and the feeling of comfort in fortunes and anxiety in misfortunes, and involves the higher and lower pleasures; and the potent force of wanting is normatively grounded in the general goal of living a truly happy life. …”
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Detection, characterisation and risk factor of Leptospira spp. among dogs and dog handlers by Goh, Soon Heng

“…The poor knowledge was likely due to the lower education level. Lack of knowledge in terms of clinical sign of the disease will be a challenge for disease management. …”
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