Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection by Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne

“…Investigations using patient-derived lymphoblastoid cell line carrying heterozygous RAD51C L134S variant showed an impairment in RAD51 chromatin association and replication fork protection, suggestive of deleteriousness of this VUS variant. Overall, our findings provide more insights into molecular roles of RAD51C in replication fork integrity maintenance and in DSB repair.…”
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Use of functional magnetic resonance imaging to identify cortical loci for lower limb movements and their efficacy for individuals after stroke by Choi, Minseok, Kim, Hyun-Chul, Youn, Inchan, Lee, Song Joo, Lee, Jong-Hwan

“…Conclusions The cortical loci associated with lower limb movements in the PCL identified in healthy participants were validated using independent groups of healthy participants and individuals after stroke. Our findings suggest that these cortical loci may be beneficial for the neurorehabilitation of lower limb movement in individuals after stroke, such as in developing effective rehabilitation interventions guided by the LI scores obtained for neuronal activations calculated from the identified cortical loci across the paretic and non-paretic sides of the brain.…”
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Patient and Health Care Worker Perceptions of Communication and Ability to Identify Emotion When Wearing Standard and Transparent Masks by Chu, Jacqueline N., Collins, Joy E., Chen, Tina T., Chai, Peter R., Dadabhoy, Farah, Byrne, James D., Wentworth, Adam, DeAndrea-Lazarus, Ian A., Moreland, Christopher J., Wilson, Jaime A. B., Booth, Alicia, Ghenand, Omkar, Hur, Chin, Traverso, Giovanni

“…CONCLUSIONS AND RELEVANCE: The findings of this study suggest that transparent masks could help improve communication during the COVID-19 pandemic, particularly for individuals who are deaf and hard of hearing.…”
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Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…Sulfur–arene interactions appear to tune the reactivity of methionine residues in a manner consistent with rates of oxidation. These findings highlight an underappreciated role for methionine—to protect catalytic histidine residues—and indicate a means by which ptRNases remain functional in oxidatively challenging physiological environments. …”
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Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…This is the first study to examine the relationship between the multi-dimensional filial piety and the work-family interface among working caregivers of the elderly, with considerations of relationship quality and gender. Findings point to potential directions for future research and offer suggestions on how to aid working caregivers to optimize interactions between work and family domains. …”
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Metal-organic architectures driven by a multifunctional 6-aminouracil spacer : structures, noncovalent interactions, and conductivity by Purkayastha, Atanu, Dhar, Sourab, Mondal, Suvra Prakash, Franconetti, Antonio, Frontera, Antonio, Ganguly, Rakesh, Kirillov, Alexander M., Misra, Tarun Kumar

“…The computational study for molecular electrostatic potential (MEP) surface energies revealed an important finding, namely a decrease of the π-acidity of the uracil ring upon coordination and a consequent increase of the π-basicity of the phenyl-sulfonate ring, resulting in effective anti-parallel π–π stacking interactions in 1 and 2. …”
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Preliminary environmental risk consideration for small UAV ground risk mapping by Chung, Han Jie, Mohd Hasrizam Che Man, Sivakumar, Anush Kumar, Low, Kin Huat

“…The regions with high rainfall, increased bird population per site and strong signal interference can be extracted.These high-risk locations can be expected to be more hazardous for sUAVs to fly in. Findings for environmental risk-tiering and risk-mapping are preliminary and based on the available environmental data as identified in this study. …”
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Growth and physical properties of organic semiconducting single crystals by Tan, Ke Jie

“…Therefore, experimental studies aids in finding parameters responsible for the physical properties of materials. …”
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New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Additionally, expansion of the phytochemical-antibiotic interaction profiles were also carried out with various classes of antibiotics and phytochemicals to understand the interaction patterns by establishing a novel interaction network that provides a baseline to identify the mechanism of action of the phytochemicals and molecular mechanism of synergy. The above findings have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals). …”
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Improved life cycle assessment for desalination : handling the choices and uncertainties by Zhou, Jin

“…The system boundary and characterization approach was selected based on our previous findings. This work provided the environment profile of Singapore’s desalinations with improved reliability. …”
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Occurrence, human exposure and dynamics of phthalates in ACMV indoor environments : method development and field studies by Chen, Ailu

“…The increases are because of either resuspension of phthalates bound to settled dust or partitioning of gas-phase phthalates to the airborne particles. The findings also demonstrate that the gas fractions of the low-volatile phthalates decrease when the airborne particle concentrations increase.…”
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先秦思想中音乐与情感的关系 ：以《孟子》《庄子》“乐”（lè）与 “乐” （yuè）的运用为核心 = The relations between music and emotion in Pre-Qin thought : an analysis of the usage of ‘Lè’ and ‘Yuè’ in the Mencius and the Zh... by 何昱慧 Ho, Adeline Yu Hui

“…Understanding the relations between“乐” and Music and Emotions in Pre-Qin text are necessary in finding the underlying significance. On the other hand, it also helps in the analysis of ideology promoted to shape the society at that point of time, which is beneficial to the progress of research in the topic.…”
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Neuronal control of cardiac excitability in pro-hypertensive states by Larsen, H

“…</p> <p><b>Chapter 7</b> forms the concluding discussion that summarises the main findings of this thesis and attempt to place it in a clinical context, and highlights avenues of further research. …”

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Steinmetz, JD, Seeher, KM, Schiess, N, Bennett, DA, Maude, RJ, Newton, CRJ, Rodriguez, JAB

“…A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. <p><b>Findings</b></p> Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. …”

Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…</p> <br> <p><strong>Findings:</strong> We sequenced 731 genomes from isolates obtained during surveillance across the three sites between Oct 1, 2016, and Aug 31, 2019 (24 months in Dhaka and Kathmandu and 34 months in Blantyre). …”

Development and characterization of collagen type I and hyaluronic acid (HA) based interlaced scaffolds for tissue engineered heart valves (TEHVS) by Nazir, R

“…While evaluated against the criterion for tissue engineered heart valve (TEHV), S-3 and S-4 among interlaced scaffolds/compositions not only matched mechanically but also showed high degradation resistance which potentially made them as '<b>close-fit</b>' candidates. Findings from this thesis indicated that collagen/HA interlaced scaffolds have the potential to fill in the niche for designing an ideal TEHV. …”

The influence of pregnancy complications on fetal and neonatal cardiovascular development by Aye, C

“…As up to 8% of pregnancies are affected by hypertensive disorders of pregnancy and approximately 10% of all births are preterm, understanding the mechanisms behind these findings and their relevance to long term cardiovascular disease in this population is of great public health interest. …”

Relationship of sperm protamine content with bull breeding soundness evaluation and sperm DNA damage by Mohamed Abbad Alfadel, Fatima

“…Post hoc pairwise comparison showed an increased DNA damage in bulls with lower protamine values. The findings of this study concluded that sperm protamine can be used as a useful biomarker to predict semen quality and male potential fertility. …”
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Anti-leukaemic and chemotherapy supportive effects of berberis vulgaris l. Fruit crude extract on in vitro and in vivo models by Saedi, Tayebeh Azam

“…From the haematological finding, the total white blood cell (WBC) count in the cancer group was high. …”
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Implementation of occupational safety and health management system in reducing ergonomic risk among certified and uncertified automotive industry workers by Ikpegbu, Mavis Amarachi

“…The data generated was statistically analyzed using SPSS version 21.0 and the finding revealed that workers in OSH certified company had a significant lower score for back posture of 14.07±1.584 compared to the workers in uncertified company 15.49±1.566, also mean values of shoulder/arm posture,wrist/hand postures and neck posture among the workers of the OSH certified company were 15.95±2.219, 15.48±1.190 and 7.13±1.053 respectively, which was significantly lower compared to the workers of the uncertified automotive company, who scored 18.94±1.943, 16.29±1.123 and 7.82±0.574, respectively. …”
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