Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

“…Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combination of antibiotics, with clarithromycin being the cornerstone of NTM treatments.…”
Get full text

Fluid-fluid displacement in porous-media microfluidics by Qiu, Yu

“…We first develop a phase-field model to simulate two-phase flow with moving contact lines in the partial wetting regime. We construct a self-consistent formulation of fluid-solid surface energy which allows prescribing arbitrary static contact angles. …”
Get full text
Get full text

Modal phase-matched bound states in the continuum for enhancing third harmonic generation of deep ultraviolet emission by Abdelraouf, Omar A. M., Anthur, Aravind P., Wang, Renshaw Xiao, Wang, Qi Jie, Liu, Hong

“…However, NLOs are limited by their bulky size, inadequate transparency at the DUV regime, and stringent phase-matching requirements for harmonic generation. …”
Get full text

India-United states nuclear initiative : an assessment of dissent. by Megha Sarmah.

Get full text

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…In each regime, we determine the biological processes that may underpin positive and negative treatment outcomes and assess which treatment (RT, HT or RT + HT) and dosing regimen maximise the reduction in tumour burden. …”

Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…Children received either 10 μg RH5.1 at 0, 1, and 2 months (Children 10M) or 10 μg RH5.1 at 0, 1, and 6 months (delayed third dose regimen; Children 10D), and were recruited in parallel, followed by children who received the dose-escalation regimen (Children DFx) and children with higher malaria pre-exposure who also received the dose-escalation regimen (High Children DFx). …”

Rethinking the efficacy of the SEANWFZ treaty by Chew, Alvin

“…ASEAN needs to rethink the purpose of the Southeast Asia Nuclear Weapons-Free Zone as a regime for nuclear non-proliferation.…”
Get full text

Pushing the limits of quantifying complexity by Ho, Matthew Shu Hui

“…Then, we shift into the quantum regime to study the analogous counterpart of the classical epsilon machine, known better as the quantum epsilon machine. …”
Get full text

Hawking radiation of extended objects by Johnson, G, March-Russell, J

“…We find that in the low-momentum regime, the power emitted is exponentially suppressed for sufficiently large radiated objects, or sufficiently small black holes, though the temperature of emission is unchanged. …”

Characterizing Direct Product Testing via Coboundary Expansion by Bafna, Mitali, Minzer, Dor

Get full text

Dynamics of localized waves in one-dimensional random potentials : statistical theory of the coherent forward scattering peak by Lee, Kean Loon, Miniatura, Christian, Grémaud, Benoît

“…Going beyond the perturbative regime, we address here the long-time dynamics of the CFS peak in a one-dimensional random system and we relate this novel interference effect to the statistical properties of the eigenfunctions and eigenspectrum of the corresponding random Hamiltonian. …”
Get full text
Get full text

Confined jet impingement boiling in a chamber with staggered pillars by Qiu, Lu, Dubey, Swapnil, Choo, Fook Hoong, Duan, Fei

“…The reasonable agreements have been reached. Three different regimes are identified based on the captured images. …”
Get full text

High-intensity two-frequency photoassociation spectroscopy of a weakly bound molecular state : theory and experiment by Kon, W. Y., Aman, J. A., Hill, J. C., Killian, T. C., Hazzard, Kaden R. A.

“…We investigate two-frequency photoassociation of a weakly bound molecular state, focusing on a regime where the AC Stark shift is comparable to the halo-state energy. …”
Get full text
Get full text

Coherently tunable triangular trefoil phaseonium metamaterial by Soci, Cesare, Nguyen, Duc Minh, Ooi, Raymond C. H.

“…We find that, in the metallic regime, the phaseonium metamaterial structure supports extremely large transmission, with optical amplification at large enough intensity of the microwave thanks to strong surface plasmon coupling; while, in the dielectric regime without microwave excitation, the transmission bandwidth can be tuned by varying the control beam intensity. …”
Get full text
Get full text

Bacteria and archaea on Earth and their abundance in biofilms by Flemming, Hans-Curt, Wuertz, Stefan

“…Most bacteria and archaea on Earth (1.2 × 10³⁰ cells) exist in the 'big five' habitats: deep oceanic subsurface (4 × 10²⁹), upper oceanic sediment (5 × 10²⁸), deep continental subsurface (3 × 10²⁹), soil (3 × 10²⁹) and oceans (1 × 10²⁹). …”
Get full text

Stratigraphy and taphonomy of tubular microfossils in Terreneuvian rocks of the Soltanieh Formation, Soltanieh Mountains, Northern Iran by Etemad-Saeed, N, Anderson, RP, Tosca, NJ, Bergmann, KD, Knoll, AH

“…X-ray diffraction and SEM-EDS reveal that Soltanieh tubes were largely infilled by variable mixes of pyrite framboids (and their oxidation products), silica, and clay minerals. In contrast, the sediment matrix is dominated by K-Al-silicate with lesser amounts of an Al-oxide/(oxy)hydroxide phase. …”

1-in-3 vs. not-all-equal: dichotomy of a broken promise by Ciardo, L, Kozik, M, Krokhin, A, Nakajima, T-V, Živný, S

“…In the present work, we investigate this constraint satisfaction problem in a regime where the promise is weakened from either side by a rainbow-free structure, and establish a complexity dichotomy for the resulting class of computational problems.…”

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria by Dahal, P

“…For dihydroartemisinin-piperaquine (DP) regimen, a study with 42 day follow-up was estimated to miss 47% [95% CI: 19 – 90%] of the treatment failures in those who were adequately dosed. …”

Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Barrett, JR, Silk, SE, Mkindi, CG, Kwiatkowska, KM, Hou, MM, Lias, AM, Kalinga, WF, Mtaka, IM, McHugh, K, Bardelli, M, Davies, H, King, LDW, Edwards, NJ, Chauhan, VS, Mukherjee, P, Rwezaula, S, Chitnis, CE, Olotu, AI, Minassian, AM, Draper, SJ, Nielsen, CM

“…In contrast, the CD4+ and CD8+ T cell responses were impacted by vaccine platform but not dosing regimen and did not correlate with in vivo growth inhibition in a challenge model. …”

Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques by Okorie, Nnaemeka, Ibe, Onyekachi Ewa, Okekpa, Simon Imakwu, Nwakpa, Anthony Chukwudi, Agom, Dansy Daniel, Pauline, Iyke-Ogbo, Adaeze, Obi Laura, Mmesomachi, Uche Bethel, Nyirahafashimana, Valentine, Obi, Ihuoma A.

“…Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. …”
Get full text