Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. …”

An investigation of friction-based tendon sheath model appropriate for control purposes by Tjahjowidodo, Tegoeh, Lau, Michael Wai Shing, Phee, Soo Jay, Do, T. N.

“…A new dynamic friction model that allows accurate description of friction lag and hysteresis behavior in two regimes, i.e. presliding and sliding regimes, for a sheath in arbitrary configuration such as helical and spatial shape has been developed. …”
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Asymptotic analysis of deep residual networks by Cont, R, Rossier, A, Xu, R

“…We first show the existence of scaling regimes for trained weights markedly different from those implicitly assumed in the neural ODE literature. …”

Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…Incorporating core strength training into regular regimens can improve athletes' overall strength, endurance, balance, control, and prevent injuries. …”
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Deliberation in the Russian state Duma: from a seat of discussion to a tool of autocracy, 1996-2021 by James, N

“…Why do legislators continue to engage in parliamentary floor activities under authoritarian regimes when policy decisions and voting outcomes are often predetermined before reaching the debate stage? …”

The four worlds of ‘welfare reality’ – social risks and outcomes in Europe by Ferragina, E, Seeleib-Kaiser, M, Spreckelsen, T

“…After three decades of welfare state crisis, change and transformation can we still speak of welfare state regimes when looking at their outcomes? The analysis of outcomes provides a picture of ‘the real worlds of welfare’ and is of considerable importance to understanding political legitimacy across countries. …”

Spontaneous Symmetry Breaking in a Polariton and Photon Laser by Ohadi, H., Kammann, E., Liew, Timothy Chi Hin, Lagoudakis, K. G., Kavokin, A. V., Lagoudakis, P. G.

“…We report on the simultaneous observation of spontaneous symmetry breaking and long-range spatial coherence both in the strong- and the weak-coupling regime in a semiconductor microcavity. Under pulsed excitation, the formation of a stochastic order parameter is observed in polariton and photon lasing regimes. …”
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A model of intonational phonology of Singapore Malay by Diyana Hamzah

“…Taking into consideration the influence of segmental structure and information structure on the intonational contour, this study aims to develop a more comprehensive model of the intonational phonology of Singapore Malay within the Autosegmental-Metrical framework. …”
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From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease by Stefani, A, Antelmi, E, Arnaldi, D, Arnulf, I, During, E, Högl, B, Hu, MMT, Iranzo, A, Luke, R, Peever, J, Postuma, RB, Videnovic, A, Gan-Or, Z

“…RBD pathophysiology is not fully clarified yet, but clinical and basic science suggest that ɑ-syn pathology begins in the lower brainstem where REM atonia circuits are located, including the sublaterodorsal tegmental/subcoeruleus nucleus and the ventral medulla, then propagates rostrally to brain regions such as the substantia nigra, limbic system, cortex. …”

Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…No randomised trials have compared these regimens and high cure rates may be achievable with shorter durations of therapy.…”

Speech enhancement using auditory-based spectral amplitude estimators by Sekar Sathiya Narayanan.

“…The proposed estimator is applied to the noisy speech signal to obtain the enhanced speech signal and the objective measures of speech quality such as the segmental SNR (SNRseg) and the log-likelihood-ratio (LLR) are obtained. …”
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Forces on oscillating uniform and tapered cylinders in a crossflow by Hover, F. S., Techet, A. H., Triantafyllou, M.S.

“…Calculation of the cross-correlation coefficient between forces at the two ends of the uniform cylinder reveals five distinct regimes as a function of the nominal reduced velocity Vrn: two regimes, for low and high values of Vrn, and far away from the value of VrS corresponding to the Strouhal frequency, show small correlation; two regimes immediately adjacent to, but excluding, VrS show strong correlation, close to 1; surprisingly, there is a regime containing the Strouhal frequency, within which correlation is low. …”
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Characterization of artemisinin resistance in plasmodium falciparum by Rocamora, Frances Maureen C.

“…In order to better understand the Artemisinin resistance phenotype, we developed Artemisinin-resistant parasite lines derived from two isogenic clones (6A and 11C) of the 3D7 strain of Plasmodium falciparum using a selection regimen that mimics how parasites interact with the drug in infected patients. …”
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What does sounding Singaporean mean? by Tan, Charmaine Li Min

“…While there is no single prototype for sounding Singaporean, it is clear that our local accent differs from other Englishes from the segmental level.…”
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Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…Developing in vitro drug combination study is essential for the development of new and effective combination regimens. In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. …”
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Using Sequenom to identify KRAS mutations in an Asian cohort of ovarian mucinous cancer by Tiong, Wen Ning

“…While there are distinct differences between mucinous epithelial ovarian cancer (mEOC) and the other subtypes of EOC, a standard treatment regimen is followed for all EOC histotypes. KRAS mutations have been observed to occur in relatively high frequencies of 50-60% in mEOC but not in other subtypes of EOC in at least three clinical studies. …”
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Development of a powermeter for a bicycle – I by Pillarisetty Venkata Pranav

“…More than just being a mode of transportation, bicycling has caught on as a competitive sport in many parts of the world and as an exercise regimen by a sizeable fraction of the global population. …”
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First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

“…Two of the reported trials (GOG-111 and the Intergroup trial) provide clear evidence that cisplatin combined with paclitaxel is a more effective regimen than one using the same dose of cisplatin combined with cyclophosphamide. …”

Criteria for Crack Formation and Air Invasion in Drying Colloidal Suspensions by Lilin, Paul, Bischofberger, Irmgard

“…We show that the pressure inside the deposit controls both the onset of crack formation and the onset of air invasion. Two distinct regimes of air invasion occur, which we can account for using the same model that further provides a quantitative criterion for the crossover between the two regimes.…”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity and mortality through inducing broad tissue damage triggering infections, graft vs. host disease, infertility, and secondary cancers. …”
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