Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…Children received either 10 μg RH5.1 at 0, 1, and 2 months (Children 10M) or 10 μg RH5.1 at 0, 1, and 6 months (delayed third dose regimen; Children 10D), and were recruited in parallel, followed by children who received the dose-escalation regimen (Children DFx) and children with higher malaria pre-exposure who also received the dose-escalation regimen (High Children DFx). …”

Bacteria and archaea on Earth and their abundance in biofilms by Flemming, Hans-Curt, Wuertz, Stefan

“…Most bacteria and archaea on Earth (1.2 × 10³⁰ cells) exist in the 'big five' habitats: deep oceanic subsurface (4 × 10²⁹), upper oceanic sediment (5 × 10²⁸), deep continental subsurface (3 × 10²⁹), soil (3 × 10²⁹) and oceans (1 × 10²⁹). …”
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Stratigraphy and taphonomy of tubular microfossils in Terreneuvian rocks of the Soltanieh Formation, Soltanieh Mountains, Northern Iran by Etemad-Saeed, N, Anderson, RP, Tosca, NJ, Bergmann, KD, Knoll, AH

“…X-ray diffraction and SEM-EDS reveal that Soltanieh tubes were largely infilled by variable mixes of pyrite framboids (and their oxidation products), silica, and clay minerals. In contrast, the sediment matrix is dominated by K-Al-silicate with lesser amounts of an Al-oxide/(oxy)hydroxide phase. …”

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria by Dahal, P

“…For dihydroartemisinin-piperaquine (DP) regimen, a study with 42 day follow-up was estimated to miss 47% [95% CI: 19 – 90%] of the treatment failures in those who were adequately dosed. …”

Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Barrett, JR, Silk, SE, Mkindi, CG, Kwiatkowska, KM, Hou, MM, Lias, AM, Kalinga, WF, Mtaka, IM, McHugh, K, Bardelli, M, Davies, H, King, LDW, Edwards, NJ, Chauhan, VS, Mukherjee, P, Rwezaula, S, Chitnis, CE, Olotu, AI, Minassian, AM, Draper, SJ, Nielsen, CM

“…In contrast, the CD4+ and CD8+ T cell responses were impacted by vaccine platform but not dosing regimen and did not correlate with in vivo growth inhibition in a challenge model. …”

Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques by Okorie, Nnaemeka, Ibe, Onyekachi Ewa, Okekpa, Simon Imakwu, Nwakpa, Anthony Chukwudi, Agom, Dansy Daniel, Pauline, Iyke-Ogbo, Adaeze, Obi Laura, Mmesomachi, Uche Bethel, Nyirahafashimana, Valentine, Obi, Ihuoma A.

“…Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. …”
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Urban site characterization using DAS dark fibers on the MIT campus in Cambridge, Massachusetts by Chang, Hilary, Nakata, Nori

“…The 1D site-response modeling for shear waves suggests that the fundamental resonance frequency is at 0.6 and 1 Hz, with a sediment-to-bedrock amplitude ratio of 6–7. This should be considered in building design to mitigate seismic hazards. …”
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The Influence of Root Geometry on Soil Cohesion and Anchoring Ability through Geologic Time by Colicci, Vittorio

“…Force laws were then derived to approximate the anchoring contributions of root weight, sediment weight, static friction, and shear strength. …”
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Data analysis of local scour around abutment in compound channel by Zhang, Ruixin

“…This model was built using the relative abutment length (L/yf), abutment aspect ratio (Lc/L), flow intensity (uf/uc), abutment shape factor (Ks), flow depth ratio (yf/ym), and relative sediment size (d50/ yf). Overall, comparisons of calculated and observed maximum equilibrium scour depths indicate that the formula is straightforward in composition and shows good credibility in the computation result.…”
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Ecocement for beach erosion control by Chua, Xue Ning

“…The experiment results had shown that EICP is feasible in cementation of the beach sand, thus reducing sediment transportation, and controlling erosion.…”
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Study of local site effects using microtremor survey method by Zhu, Cheng.

“…Additionally, empirical relations are proposed between fundamental frequency and sediment thickness for different shear-wave velocity ranges. …”
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Run-up related to onshore tsunami flows by Sim, Shawn Yisheng

“…Hence, based on the trim-line time series recorded, we provided a hypothetical sedimentation time that can be obtained using non-sediment laden flow tests.…”
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Metasomatism of the continental crust and its impact on surface uplift: insights from reactive‐transport modelling by Worthington, JR, Chin, EJ, Palin, RM

“…High-elevation, low-relief continental plateaus are major topographic features and profoundly influence atmospheric circulation, sediment transport and storage, and biodiversity. Although orogenic surface-uplift mechanisms for modern continental plateaus near known plate margins like Tibet are well-characterized, they cannot account for examples in intracontinental settings like the Colorado Plateau. …”

Geochemical and Sr–Nd–Hf isotopic evidence for Cenozoic partial melting of mantle beneath Natanz, Central Iran by Babazadeh, S, D'Antonio, M, Raeisi, D, Furman, T, Santosh, M, Di Renzo, V, Klötzli, U, Choi, SH, Ghalamghash, J, Cottle, JM, Palin, R

“…Combined modelling of trace element and isotopic data suggests that the most mafic Natanz magmas could have formed through ∼5% melting of a source comprising 99% depleted mantle +1% sediment, with the melts modified subsequently by ∼3% contamination by Cadomian upper crustal components. …”

Combining stratigraphy and tectonics to understand intermittent deposition on the outer rise offshore Sumatra, Indonesia by Tan, Li Ching

“…We present a robust method of estimating the ages of deep sea sediments at active margins by relating tectonic deformation of the sediments to a known deformation rate. …”
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Prediction of mean axial velocity of a free turbulent propeller jet by Hong, Jian-Hao, Yeh, Po-Hung, Chiew, Yee-Meng

“…Based on results of this study, the axial velocity profile calculated using the point-source method may be applied to investigate the scour and sediment resuspension induced by a propeller jet.…”
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Small scale 3D jet scour by Nuramirah Suyin Zaihan

“…Analysis of the compiled data points suggests that the scour hole geometry was influenced by the sediment size of the bed material (d50), the mean velocity of jet at culvert pipe outlet (Uo) and the tailwater depth (Ho). …”
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Petrogenesis of Permian high-Mg diorites in the northern margin of the North China Craton: Evidence of crust–mantle interaction by Li, M, Xu, X, Palin, RM

“…The Nd-Hf isotopic compositions of the high-Mg diorites are decoupled as a consequence of interactions between subducting sediment-derived fluids and mantle peridotite. In light of the above, we propose a two-stage process for the formation of the Xinhure high-Mg diorite, comprising (1) partial melting of enriched mantle peridotite followed by (2) interaction between mantle-derived high-Mg diorite melts and continental crust-derived melts. …”

Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

“…</p> <br> <p><strong>Interventions:</strong> ART regimes containing different NRTI drugs.</p> <br> <p><strong>Assessment of risk of bias:</strong> Newcastle-Ottawa Scale and GRADE.…”

Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…The accuracy was further supported by the correlation between WTC-based test results and patients' clinical responses in a separate validation study, where the neoadjuvant treatment regimens of 15 BC patients were mimicked. Collectively, the WTC model allows us to accomplish personalized drug testing within 10 d, even for small-sized tumors, highlighting its potential for individualized BC therapy. …”
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