The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…The first-line treatment of metastatic colorectal cancer (mCRC) is frequently based on combination chemotherapeutic regimens, where 5-fluorouracil is either associated with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX). …”

The prevention and management of chronic kidney disease among patients with metabolic syndrome by Zhu, D, Judge, PK, Wanner, C, Haynes, R, Herrington, WG

“…In addition, statin-based regimens lower low-density lipoprotein cholesterol and reduce the risk of atherosclerotic disease (with no clinically meaningful effect on kidney outcomes). …”

Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML by Risueño, A, See, WL, Bluemmert, I, de Botton, S, DiNardo, CD, Fathi, AT, Schuh, AC, Montesinos, P, Vyas, P, Prebet, T, Gandhi, A, Hasan, M

“…We recently reported results from the phase 3 IDHENTIFY trial (NCT02577406) showing improved response rates and event-free survival with enasidenib monotherapy compared with conventional care regimens (CCR) in heavily pretreated, older patients with late-stage R/R AML bearing IDH2 mutations. …”

Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

“…Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar.…”
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Psychosocial predictors of self-reported medical adherence in patients with heart failure over 6 months : an examination of the influences of depression, self-efficacy, social supp... by Shen, Biing-Jiun, Maeda, Uta

“…Background Poor adherence to medical regimens is a serious problem that interferes with heart failure (HF) patients’ disease management and contributes to poor clinical outcomes. …”
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Clostridium difficile bacteriophage finding under normal and iron-limited conditions for the isolation of potential siderophore receptor-specific phages by Lim, Edsel Yong Xun

“…Phage therapy, known for its specificity of action, has emerged as a promising candidate for combating CDI, offering the potential to circumvent gut microbiome dysbiosis associated with conventional antibiotic regimens. However, research on Clostridium difficile (C. difficile) phage hunting has been relatively limited. …”
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Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

“…Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combination of antibiotics, with clarithromycin being the cornerstone of NTM treatments.…”
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Novel viral vector vaccines for tropical infections by Rampling, T

“…Two studies evaluate the safety, efficacy and immunogenicity of a combination vaccination regimen containing the leading pre- erythrocytic <em>P. falciparum</em> malaria vaccine RTS,S/AS01B and the liver stage, viral vector heterologous prime-boost regimen of ChAd63 ME-TRAP and MVA ME-TRAP. …”

Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques by Okorie, Nnaemeka, Ibe, Onyekachi Ewa, Okekpa, Simon Imakwu, Nwakpa, Anthony Chukwudi, Agom, Dansy Daniel, Pauline, Iyke-Ogbo, Adaeze, Obi Laura, Mmesomachi, Uche Bethel, Nyirahafashimana, Valentine, Obi, Ihuoma A.

“…Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. …”
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Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…The accuracy was further supported by the correlation between WTC-based test results and patients' clinical responses in a separate validation study, where the neoadjuvant treatment regimens of 15 BC patients were mimicked. Collectively, the WTC model allows us to accomplish personalized drug testing within 10 d, even for small-sized tumors, highlighting its potential for individualized BC therapy. …”
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Antiretroviral therapy optimisation without genotype resistance testing : a perspective on treatment history based models by Prosperi, Mattia C. F., Sloot, Peter M. A., van de Vijver, David A. M. C., Rosen-Zvi, Michal, Altmann, André, Zazzi, Maurizio, Schülter, Eugen, Struck, Daniel, Di Giambenedetto, Simona, Kaiser, Rolf, Vandamme, Anne-Mieke, Sönnerborg, Anders

“…Sensitivity analyses, carried out on a data subset that included antiretroviral regimens commonly used in low to middle income countries, confirmed our findings. …”
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The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines by McLean, Gary R., Kamil, Jeremy, Lee, Benhur, Moore, Penny, Schulz, Thomas F., Muik, Alexander, Sahin, Ugur, Tureci, Ozlem, Pather, Shanti

“…Although data on the effectiveness of the primary regimen against omicron (B.1.1.529) are limited, booster programs using mRNA vaccines have been shown to restore protection against infection and symptomatic disease (regardless of the vaccine used for the primary regimen) and maintain high effectiveness against hospitalization. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…Background: While the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore. …”
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Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

“…ART containing zidovudine was associated with increased risk of very preterm birth (1.59; 1.01-2.49), small for gestational age (1.33; 1.03-1.70), very small for gestational age (1.63; 1.25-2.13), stillbirth (2.23; 1.10-4.55), and neonatal death (1.65; 1.08-2.52), compared to ART not containing zidovudine. For ART regimens also containing either lamivudine or emtricitabine, zidovudine was associated with increased risk of very preterm birth (1.62; 1.04-2.52), small for gestational age (1.52; 1.28-1.82), very small for gestational age (1.68; 1.36-2.06), stillbirth (2.19; 1.03-4.67), and neonatal death (1.65; 1.08- 2.52), compared to ART containing tenofovir disoproxil fumarate. …”

Role of different dendritic cell subsets in vivo by Abdul Rashid Mohammad Muzaki

“…In a dextran sodium sulphate (DSS) model of colonic inflammation, ablation of CD103+ CD11b- colonic DCs resulted in exacerbated colitis, while ablation of colonic CD103+ CD11b+ DCs resulted in resistance to colitis when subjected to the same DSS regiment. Hence our results highlight the opposing roles of these two distinct colonic DC subsets in controlling DSS-induced colonic inflammation. …”
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Phonological analysis of syllabic changes of Arabic loan verbs by Muhaimin Syaqiq Mawaridi, Abdul Azim Mohamad Isa, Lutfi Hassan

“…The reduction of syllable segments refers to a segmental reduction in the first, second or third syllable. …”
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Smuggling of Migrants in Malaysia: The Case Study of Illegal Immigrants in the Northern Region by Ajis, Mohd Na'eim, Ahmad Zakuan, Ummu Atiyah, Mohd. Zain, Zawiyah, Keling, Mohamad Faisol

“…Relevant authorities like Malaysian Maritime Enforcement Agency, Malaysia Immigration Department and Border Ranger Regiment, are being interviewed. Findings reveal that the activities of migrant smuggling are occurring in the Northern Region of the Peninsular Malaysia. …”
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Behaviour of joints in tunnel linings by Alevey, Niall Mac, Ashraf Mohamed Hefny

“…Precast concrete tunnel segments are used extensively to construct tunnel linings. …”
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Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study by Greggio, J, Malamateniou, C, Baruteau, KP, Reyes-Aldasoro, CC, Huckstep, OJ, Francis, JM, Williamson, W, Leeson, P, Lewandowski, AJ, Lapidaire, W

“…In contrast, preterm females showed higher odds of a group 4a variant (circles with one or more accessory segments, without any absent segments) in comparison to their full-term counterparts (p = 0.020). …”

The dietetic practice of prescribing amino acid-based formulas in paediatrics patients without cow’s milk allergy: a single centre retrospective study by O’Connor, Graeme, Mansell, Melissa

“…Data were collected on demographics, anthropometrics, feed regimens, gastrointestinal symptoms, proton pump inhibitor use and serum phosphate concentration Results: 203 children were prescribed an AAF during the data collection period, of these, 154 of 203 (76%) patients had no allergies. …”
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