Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. …”

An investigation of friction-based tendon sheath model appropriate for control purposes by Tjahjowidodo, Tegoeh, Lau, Michael Wai Shing, Phee, Soo Jay, Do, T. N.

“…A new dynamic friction model that allows accurate description of friction lag and hysteresis behavior in two regimes, i.e. presliding and sliding regimes, for a sheath in arbitrary configuration such as helical and spatial shape has been developed. …”
Get full text
Get full text

Asymptotic analysis of deep residual networks by Cont, R, Rossier, A, Xu, R

“…We first show the existence of scaling regimes for trained weights markedly different from those implicitly assumed in the neural ODE literature. …”

Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…Incorporating core strength training into regular regimens can improve athletes' overall strength, endurance, balance, control, and prevent injuries. …”
Get full text

Deliberation in the Russian state Duma: from a seat of discussion to a tool of autocracy, 1996-2021 by James, N

“…Why do legislators continue to engage in parliamentary floor activities under authoritarian regimes when policy decisions and voting outcomes are often predetermined before reaching the debate stage? …”

The four worlds of ‘welfare reality’ – social risks and outcomes in Europe by Ferragina, E, Seeleib-Kaiser, M, Spreckelsen, T

“…After three decades of welfare state crisis, change and transformation can we still speak of welfare state regimes when looking at their outcomes? The analysis of outcomes provides a picture of ‘the real worlds of welfare’ and is of considerable importance to understanding political legitimacy across countries. …”

Spontaneous Symmetry Breaking in a Polariton and Photon Laser by Ohadi, H., Kammann, E., Liew, Timothy Chi Hin, Lagoudakis, K. G., Kavokin, A. V., Lagoudakis, P. G.

“…We report on the simultaneous observation of spontaneous symmetry breaking and long-range spatial coherence both in the strong- and the weak-coupling regime in a semiconductor microcavity. Under pulsed excitation, the formation of a stochastic order parameter is observed in polariton and photon lasing regimes. …”
Get full text
Get full text

Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…No randomised trials have compared these regimens and high cure rates may be achievable with shorter durations of therapy.…”

The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…The first-line treatment of metastatic colorectal cancer (mCRC) is frequently based on combination chemotherapeutic regimens, where 5-fluorouracil is either associated with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX). …”

Forces on oscillating uniform and tapered cylinders in a crossflow by Hover, F. S., Techet, A. H., Triantafyllou, M.S.

“…Calculation of the cross-correlation coefficient between forces at the two ends of the uniform cylinder reveals five distinct regimes as a function of the nominal reduced velocity Vrn: two regimes, for low and high values of Vrn, and far away from the value of VrS corresponding to the Strouhal frequency, show small correlation; two regimes immediately adjacent to, but excluding, VrS show strong correlation, close to 1; surprisingly, there is a regime containing the Strouhal frequency, within which correlation is low. …”
Get full text

Characterization of artemisinin resistance in plasmodium falciparum by Rocamora, Frances Maureen C.

“…In order to better understand the Artemisinin resistance phenotype, we developed Artemisinin-resistant parasite lines derived from two isogenic clones (6A and 11C) of the 3D7 strain of Plasmodium falciparum using a selection regimen that mimics how parasites interact with the drug in infected patients. …”
Get full text

Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…Developing in vitro drug combination study is essential for the development of new and effective combination regimens. In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. …”
Get full text

Using Sequenom to identify KRAS mutations in an Asian cohort of ovarian mucinous cancer by Tiong, Wen Ning

“…While there are distinct differences between mucinous epithelial ovarian cancer (mEOC) and the other subtypes of EOC, a standard treatment regimen is followed for all EOC histotypes. KRAS mutations have been observed to occur in relatively high frequencies of 50-60% in mEOC but not in other subtypes of EOC in at least three clinical studies. …”
Get full text

Development of a powermeter for a bicycle – I by Pillarisetty Venkata Pranav

“…More than just being a mode of transportation, bicycling has caught on as a competitive sport in many parts of the world and as an exercise regimen by a sizeable fraction of the global population. …”
Get full text

First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

“…Two of the reported trials (GOG-111 and the Intergroup trial) provide clear evidence that cisplatin combined with paclitaxel is a more effective regimen than one using the same dose of cisplatin combined with cyclophosphamide. …”

Criteria for Crack Formation and Air Invasion in Drying Colloidal Suspensions by Lilin, Paul, Bischofberger, Irmgard

“…We show that the pressure inside the deposit controls both the onset of crack formation and the onset of air invasion. Two distinct regimes of air invasion occur, which we can account for using the same model that further provides a quantitative criterion for the crossover between the two regimes.…”
Get full text

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity and mortality through inducing broad tissue damage triggering infections, graft vs. host disease, infertility, and secondary cancers. …”
Get full text

A comparative analysis of missing data imputation techniques on sedimentation data by Loh, Wing Son, Ling, Lloyd, Chin, Ren Jie, Lai, Sai Hin, Loo, Kar Kuan, Seah, Choon Sen

“…A comparative analysis on the missing fine sediment data imputation performance was made based on four different techniques, namely the k-Nearest Neighbourhood (k-NN), Support Vector Regression (SVR), Multiple Regression (MR), and Artificial Neural Network (ANN), under the single imputation (SI) and multiple imputation (MI) regimes. Across different missing data proportions (10%-50%), the ANN demonstrated optimal results with consistent performance metrics recorded over both SI and MI regimes. …”
Get full text

Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
Get full text

Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats by Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam

“…The present study has shown that, despite the significant differences in some of the drug pharmacokinetic parameters between sheep and goats for the i.v. route, identical intravenous and intramuscular dosage regimens of tylosin may be recommended for the two species.…”
Get full text