A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53 by Wong, Jin Huei, Alfatah, Mohammad, Sin, Mei Fang, Sim, Hong May, Verma, Chandra Shekhar, Lane, David P., Arumugam, Prakash

“…In addition, we identified a conserved segment in the core DNA-binding domain of p53 that facilitates stable interaction with Mdm2 in yeast cells and in vitro. …”
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Human detection and tracking in surveillance videos by Wang, Bing

“…The thesis aims to improve the state-of-the-art performance in human detection and tracking by studying the human detectors, extended tracking of track segments (tracklets) generated from short term tracking of detection responses. …”
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Factors Influencing Students Intention to Choose Career of Halal Food Industry in Malaysia using Theory of Planned Behavior by Abu Bakar, Nashirah, Rosbi, Sofian, Haji Hashim, Hydzulkifli, Che Arshad, Noraziah

“…The halal food industry is a market segment involved with food items and beverages that are strictly prepared according to rules underlined by the Islamic dietary law. …”
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Relationship between synoptic scale meteorology, aircraft parameters, and observable contrails by Barbosa, Maria Paula

“…All algorithms rely on the use of "similarity measures" which we define as the differences in distance, heading, and altitude between a contrail and flight line segment candidates. We define two-dimensional (2D) algorithms as those that use only distance and heading difference measures and the ones that additionally include altitude as three-dimensional (3D) algorithms. …”
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Rail transit OD matrix estimation and journey time reliability metrics using automated fare data by Chan, Joanne, S.M. Massachusetts Institute of Technology

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Analysis and design of curved steel beam member in elevation using Eurocode 3 by Yandarmadi, Kelvin

“…In the first part of the study, the obtained result based on the formula produced from the equilibrium equation is compared with the design software analysis and multiple numbers of linear segments hand calculation with similar dimension and load acting on the beam member. …”
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Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…In addition, mutagenesis and structural studies unveiled an allosteric site, termed the 'DEK' (encompassing the key structural elements DFG motif, Glu315 on the αC helix, and kinase inhibitory segment), crucial in modulating kinase activity.</p> <p>To gain a deeper understanding of the action mechanism underlying PAK1 small molecule activators, fluorescence resonance energy transfer (FRET), superresolution single molecular imaging, and mass photometry were applied to illustrate the conformational changes and alterations in PAK1 dimerization upon the binding of small molecule activators. …”

Localization and motion planning of mobile robots by Dai, Yunxiang

“…Afterward, a novel reference path segment generation and switching mechanism are proposed to bridge the perception with the low-level controller. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…The MtRel NTD in the presence of TGS domain showed almost similar synthetic activity as of MtRel NTD and approximately 3 fold higher than that of MtRel showing auto-inhibition by rest of the C-terminus MtRel segment. The MtRel ACT structure was determined as a dimer and the oligomeric state was further confirmed using SAXS. …”
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Associations between health literacy and health care utilization and mortality in patients with coexisting diabetes and end-stage renal disease : a prospective cohort study by Griva, Konstantina, Loong, Russel K. L., Nandakumar, Mooppil, Rajeswari, Moothathamby, Khoo, Eric Y. H., Lee, Vanessa Y. W., Kang, Augustine W. C., Osborne, Richard H., Brini, Stefano, Newman, Stanton P.

“…Patients with diabetes (DM) comprise the fastest growing segment of patients with end-stage renal disease (ESRD). …”
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Sustaining antimicrobial stewardship in a high-antibiotic resistance setting by Ng, Tat Ming, Heng, Shi Thong, Chua, Boon Hou, Ang, Li Wei, Tan, Sock Hoon, Tay, Hui Lin, Yap, Min Yi, Quek, Jason, Teng, Christine B., Young, Barnaby Edward, Lin, Ray, Ang, Brenda, Lee, Tau Hong, Lye, David C.

“…Design, Setting, and Participants: This cohort study used an interrupted time series with segmented regression analysis of data from January 2007 to December 2018. …”
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Low-power high-performance SAR ADC with redundancy and digital error-correction by Sharma, Sunny

“…The demands for data converters have soared in the last decade with the boom in consumer electronics, smart devices, autonomous vehicles, and automotive segments. The current trend among Nyquist-rate data converters, for example successive approximation register (SAR) analog-to-digital converters (ADC), tends towards high speeds and medium-to-high resolution. …”
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Visualization of engine design, simulation and optimization by Wang, Yan Chao

“…Starting from a new distance function and neighborhood relationship between sites, we divide the space by axis-aligned segments. Then a sweepline+skyline based heuristic algorithm is proposed to allocate the partitioned spaces to form an orthogonal Voronoi diagram with orthogonal rectangles. …”
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Synthesizing photorealistic images with deep generative learning by Zheng, Chuanxia

“…To achieve this goal, a new pipeline is presented that interleaves the two tasks of instance segmentation and scene completion through multiple iterations, solving for objects in a layer-by-layer manner. …”
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Discrete differential geometry driven methods for architectural geometry by Yao, Sidan

“…We then trace integral curves with a rounding strategy to encourage them to go through mesh vertices, which can effectively reduce the number of short segments. Finally, we partition the triangle mesh along the integral curves to extract the quadrilateral patches. …”
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Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification by Chan, Hung, Li, Qing, Wang, Xiansong, Liu, Wing Yingzhi, Hu, Wei, Zeng, Judeng, Xie, Chuan, Kwong, Thomas Ngai Yeung, Ho, Idy Hiu Ting, Liu, Xiaodong, Chen, Huarong, Yu, Jun, Ko, Ho, Chan, Raphael Chiu Yeung, Ip, Margaret, Gin, Tony, Cheng, Alfred Sze Lok, Zhang, Lin, Chan, Matthew Tak Vai, Wong, Sunny Hei, Wu, William Ka Kei

“…In mice, gavage with TcdB-hyperproducing C. difficile or injection of TcdB into ligated colon segments caused prominent MITF downregulation in macrophages. …”
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Mechanically durable and damage resilient dielectric elastomer actuators by Tan, Matthew Wei Ming

“…By tuning hard-to-soft segment ratios and molecular weights of polydiols, carboxyl polyurethanes (PULM0) attained large mechanical toughness (96.5 MJ m-3) and puncture resistance. …”
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Genetic and molecular characterisation of non-tissue culture adapted influenza B viruses detected in Singapore between 2004-2009 by Muhammad Raihan Jumat

“…Only one specimen had both these gene segments from the Yamagata lineage. This finding has resulted in us determining several vaccine mismatches over the six years in focus. …”
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Studies on the assessment of abdominal aortic aneurysm rupture risk by Canchi, Tejas

“…This was done using a combination of in-house segmentation codes and commercial finite element analysis (FEA) software. …”
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Tracking and detecting objects in image sequence by Wang, Li

“…Then, a so-called “split-merge” approach is proposed to over-segment a foreground region into subregions and then cluster them into a number of object regions by using the proposed boundary based similarity metric. …”
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