Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…The accuracy was further supported by the correlation between WTC-based test results and patients' clinical responses in a separate validation study, where the neoadjuvant treatment regimens of 15 BC patients were mimicked. Collectively, the WTC model allows us to accomplish personalized drug testing within 10 d, even for small-sized tumors, highlighting its potential for individualized BC therapy. …”
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Antiretroviral therapy optimisation without genotype resistance testing : a perspective on treatment history based models by Prosperi, Mattia C. F., Sloot, Peter M. A., van de Vijver, David A. M. C., Rosen-Zvi, Michal, Altmann, André, Zazzi, Maurizio, Schülter, Eugen, Struck, Daniel, Di Giambenedetto, Simona, Kaiser, Rolf, Vandamme, Anne-Mieke, Sönnerborg, Anders

“…Sensitivity analyses, carried out on a data subset that included antiretroviral regimens commonly used in low to middle income countries, confirmed our findings. …”
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Simulated training on interventional diagnostic device by Chiang, Patricia Wei Yin.

“…Catheter-heart-wall interaction is modeled through geometrical intersections between heart-wall plane and catheter segment and iterative adjustments progressing from the pivot to the catheter tip. …”
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Human face recognition using line edge information by Gao, Yong Sheng.

“…LEM and the proposed generic Line Segment Hausdorff Distance measure provide a new way for face coding and recognition.…”
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Exploring human computation via interactive online application by Lee, Ming Hua.

“…Subsequently, these tags will help to segment an arbitrary image into appropriate sub-images, each depicting an object with meaningful labels. …”
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The Red Box Project : a campaign to engage Singaporean youth in total defence by Kam, Collin Siu Leong, Lai, Jared Yi Qiang, Lim, Xuan'an

“…Beyond achieving the output objectives in terms of the quantity of donations collected and volunteers recruited, the Project provides a strong case study for the examination of the potential and effectiveness of youth-oriented causes as a tool for reaching the youth segment with a government message. We discuss the results of our campaign and subsequently the insights that these results provide into the state of understanding,appreciation and internalization of Total Defence among Singaporean youth. …”
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Optimization of petrochemical supply chain by Foo, Dan Yu Yao.

“…There is limited research on optimizing the maritime transportation segment of the supply chain. There is even lesser literature on the overall optimization of the petrochemical supply chain with considerations to the interaction between refineries and transportation providers. …”
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Analysis and future outlook of tanker sector in intra-asia shipping by Ng, Alvin Yong Han

“…Of the 4 major energy commodities traded, crude oil and oil products are classified under the tanker market segment due to their mode of transportation. The aim of this report is to analyze the current trade patterns in the tanker market followed by identifying the future opportunities, threats and uncertainties of intra-Asia tanker shipping. …”
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Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex by Diao, X, Shang, Q, Guo, M, Huang, Y, Zhang, M, Chen, X, Liang, Y, Sun, X, Zhou, F, Zhuang, J, Liu, S, Vogel, CFA, Rastinejad, F, Wu, D

“…Our findings further reveal the structural underpinnings of a ligand-driven activation mechanism, whereby a segment of the AHR protein undergoes a structural transition from chaperone engagement to ARNT heterodimer stabilization, to generate the transcriptionally competent assembly. …”

Characterization and identification of Oya virus, a Simbu serogroup virus of the genus Bunyavirus, isolated from a pig suspected of Nipah virus infection by Kono, Y., Yusnita, Y., Mohd Ali, A. R., Maizan, M., Sharifah, S. H., Fauzia, O., Kubo, M., Aziz, A. J.

“…The sequence data of the product revealed that the partial gene of Oya virus S-RNA segment had 65-70% homology with published cDNA sequences of Simbu serogroup viruses. …”

Decentralized Administration and Minority Accommodation in Sri Lanka: Analyzing Status, Issues, Challenges and Prospects by Yusoff, Moharnrnad Agus, Sarjoon, Athambawa, Asrinaldi, Asrinaldi, Mohd. Zain, Zawiyah

“…One of the major objectives of decentralization is to facilitate the administrative machinery of a government to deliver public services efficiently and effectively to all segment of public, including the minority groups living within a state. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…Background: While the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore. …”
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Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

“…ART containing zidovudine was associated with increased risk of very preterm birth (1.59; 1.01-2.49), small for gestational age (1.33; 1.03-1.70), very small for gestational age (1.63; 1.25-2.13), stillbirth (2.23; 1.10-4.55), and neonatal death (1.65; 1.08-2.52), compared to ART not containing zidovudine. For ART regimens also containing either lamivudine or emtricitabine, zidovudine was associated with increased risk of very preterm birth (1.62; 1.04-2.52), small for gestational age (1.52; 1.28-1.82), very small for gestational age (1.68; 1.36-2.06), stillbirth (2.19; 1.03-4.67), and neonatal death (1.65; 1.08- 2.52), compared to ART containing tenofovir disoproxil fumarate. …”

Dynamic scan chains : a novel architecture to lower the cost of VLSI test by Sitchinava, Nodari S. (Nodari Shalva), 1981-

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Segregation in carbon steels by Liong, Wei Hao.

“…The occurrence of an optimum temperature at which the segregation centerline is removed and the minimal loss of strength is discussed. In the concluding segment, a general overview of analysis is given and possible recommendations are proposed as well.…”
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Studies of bioactivity of proteins encapsulated in liposomes by Ho, Amelia May Teng.

“…The eye has a unique structure with barriers which pose challenges for drug delivery, especially to the posterior segment of the eye. As such, drug delivery systems such as liposomes have recently been investigated. …”
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Efficient feedforward categorization of objects and human postures with address-event image sensors by Chen, Shoushun, Akselrod, Polina, Zhao, Bo, Carrasco, Jose Antonio Perez, Linares-Barranco, Bernabe, Culurciello, Eugenio

“…The detected line features are organized into vectorial segments. After feature extraction, a modified line segment Hausdorff-distance classifier combined with on-the-fly cluster-based size and position invariant categorization. …”
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The geometry and matching of lines and curves over multiple views by Schmid, C, Zisserman, A

“…<br> A set of algorithms are then described for automatically matching individual line segments and curves between images. The algorithms use both photometric information and the multiple view geometric relationships. …”

Mechanism of traffic jams at speed bottlenecks by Quek, Wei Liang, Chew, Lock Yue

“…In this paper, the interactions between traffic flow and road topology will be studied, particularly the relationship between a sharp bend in a road segment and traffic jams. As suggested by Sugiyama[1], when car density exceeds a critical density, the fluctuations in the speed of each car will lead to greater fluctuations in speed of the cars behind it. …”
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Characterization of single amino acid substitutions in the β2 integrin subunit of patients with leukocyte adhesion deficiency (LAD)-1 by Guan, Siyu, Tan, Suet-Mien, Li, Yan, Torres, Jaume, Uzel, Gulbu, Xiang, Liming, Law, S.K. Alex

“…Integrins with the β2-G150D mutation fail to bind ligands, possibly due to the failure of the α1 segment of the βI domain to assume an α-helical structure. …”
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