Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…These results provide evidence for 5FU-CaCO3np as a novel regimen against colon cancer. Combining 5FU-CaCO3np and TQ may offer a new perspective for colon cancer therapy.…”
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Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

“…Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combination of antibiotics, with clarithromycin being the cornerstone of NTM treatments.…”
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A study of crack propagation in microforming tools by Muhammad Shahid Shith.

“…This is carried out by using properties of AISI M2 as a reference tool steel material and ABAQUS/Standard 6.9 to run simulations. The project is segmented into four different phases. The first phase consisted of modeling a global model of the predetermined microforming die. …”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

Human anatomy in ancient Indian sculptures of Gandhara art illustrating the fasting Buddha by Abrahams, Peter, Mogali, Sreenivasulu Reddy

“…However, certain errors of anatomical knowledge including an extra number of ribs and a segmented sternum were noticed. Further, they also seemed to have some basic ideas about the physiological changes that occur during starving, as it is evident in the Buddha sculptures, which are skinny and emaciated.…”
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Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…In each regime, we determine the biological processes that may underpin positive and negative treatment outcomes and assess which treatment (RT, HT or RT + HT) and dosing regimen maximise the reduction in tumour burden. This work enables us to generate a set of hypotheses that may explain some of the widely varying tumour behaviours observed experimentally and clinically.…”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques by Okorie, Nnaemeka, Ibe, Onyekachi Ewa, Okekpa, Simon Imakwu, Nwakpa, Anthony Chukwudi, Agom, Dansy Daniel, Pauline, Iyke-Ogbo, Adaeze, Obi Laura, Mmesomachi, Uche Bethel, Nyirahafashimana, Valentine, Obi, Ihuoma A.

“…Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. …”
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Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA) by Tan, Bingyao, Chua, Jacqueline, Barathi, Veluchamy Amutha, Baskaran, Mani, Chan, Anita, Lin, Emily, Ang, Marcus, Klose, Gerd, Schmetterer, Leopold

“…The areas of non-perfusion, also called flow voids, were segmented with a structural, intensity adjusted, uneven illuminance-compensated algorithm and the new technique was compared to previously published methods. …”
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High-mass loading V3O7·H2O nanoarray for Zn-ion battery : new synthesis and two-stage ion intercalation chemistry by Chen, Duo, Lu, Menjie, Wang, Boran, Cheng, Hongfei, Yang, Hang, Cai, Dong, Han, Wei, Fan, Hong Jin

“…The stepwise and reversible intercalation process is manifested by different diffusion energy barriers and segmented electrochemical kinetics in various discharge depths. …”
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Advanced Reconstruction Techniques for CUORE: Searching Beyond the Standard Model with Cryogenic Calorimeters by Mayer, Daniel W.

“…This work establishes methods and analysis techniques to treat CUORE as a segmented detector in aggregate, with a focus towards identifying and reconstructing track-like signatures induced by high-energy through-going particles traversing the detector array. …”
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Building fabric improvement and heat pump deployment: a set of policy conundrums by Killip, G, Topouzi, M, Fawcett, T

“…</p> <br> <p>The paper examines building interventions through the concept of 'trigger points.' It evaluates a segmented market approach and proposes a policy framework that emphasises 'understanding first' as a strategy to facilitate informed decision-making, rather than imposing specific measures. …”

STandards for reporting interventions in clinical trials of tuina/massage (STRICTOTM): extending the CONSORT statement by Zhang, Xuan, Liang, Feng, Lau, Chung Tai, Chan, Jacky C. P., Wang, Nana, Deng, Jiashuai, Wang, Juan, Ma, Yanfang, Zhong, Linda Lidan, Zhao, Chen, Yao, Liang, Wu, Taixiang, Lyu, Aiping, Tian, Guihua, Shang, Hongcai, Miao, Jiangxia, Bian, Zhaoxiang

“…Results: A checklist of seven items (namely Tuina/Massage rationale, details of Tuina/Massage, intervention regimen, other components of the intervention, Tuina/Massage provider background, control or comparator interventions, and precaution measures), and 16 subitems were developed. …”
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Extremely versatile deformability beyond materiality : a new material platform through simple cutting for rugged batteries by Kim, Kee-Bum, Lee, Young-Joo, Costa, Avelino, Lee, Yu-Ki, Jang, Tae-Sik, Lee, Myoung-Gyu, Joo, Young-Chang, Oh, Kyu Hwan, Song, Juha, Choi, In-Suk

“…The hierarchy and number of segmentations are the key parameters of the deformation mechanism for auxetic cut shape-reconfigurable battery systems. …”
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Investigation of ion transport and electrochemical performance of fluorinated and lithiated gel polymer electrolytes for lithium ion batteries by Shubha Nageswaran

“…The effect of reduced ionic coupling, increased lithium ion dissociation and increased chain segmental motion on the ion transporting abilities of the P(VdF-co-HFP) GPE and PSSLi gel was systematically studied. …”
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A New Variational Method for Bias Correction and Its Applications to Rodent Brain Extraction by Chang, Huibin, Huang, Weimin, Wu, Chunlin, Huang, Su, Guan, Cuntai, Sekar, Sakthivel, Bhakoo, Kishore Kumar, Duan, Yuping

“…On the other hand, the results of brain extraction are compared against manually segmented gold standards, BET, BSE and 3-D PCNN based on a number of metrics. …”
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Controllable broadband multicolour single-mode polarized laser in a dye-assembled homoepitaxial MOF microcrystal by He, Huajun, Cui, Yuanjing, Li, Hongjun, Shao, Kai, Chen, Banglin, Qian, Guodong

“…Here, we demonstrate a single crystal with multiple segments based on the host-guest metal-organic framework ZJU-68 hierarchically hybridized with different dye molecules generating controllable single-mode green, red, and near-infrared lasing, with the lasing mode mechanism revealed by computational simulation. …”
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