Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. However, HSCT regimens currently commonly utilize genotoxic chemotherapy and/or total body irradiation (TBI) conditioning which causes significant morbidity and mortality through inducing broad tissue damage triggering infections, graft vs. host disease, infertility, and secondary cancers. …”
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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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Characterisation of novel electroactive consortia from environmental samples enriched through potentiostatic growth by Doyle, Lucinda Elizabeth

“…Comparison revealed the enriched community from canal sediment was superior to that from the mangrove sediment in terms of electrogenic activity when evaluated by chronoamperometry, and was chosen for further characterisation. …”
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Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats by Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam

“…The present study has shown that, despite the significant differences in some of the drug pharmacokinetic parameters between sheep and goats for the i.v. route, identical intravenous and intramuscular dosage regimens of tylosin may be recommended for the two species.…”
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Droplet impact on superheated surfaces by Khavari, Mohammad

“…The former case is commonly referred to as the contact boiling regime, while the latter one is known as the Leidenfrost regime. …”
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Deliberation in the Russian state Duma: from a seat of discussion to a tool of autocracy, 1996-2021 by James, N

“…Why do legislators continue to engage in parliamentary floor activities under authoritarian regimes when policy decisions and voting outcomes are often predetermined before reaching the debate stage? …”

A systems biology approach to define SARS-CoV-2 correlates of protection in non-human primates by Brady, C

“…Novel predictors of protection included low peripheral intermediate monocyte prevalence during the vaccination regimen and low seasonal coronavirus IgG at baseline - parameters which also predicted high spike IgG titres post- vaccination. …”

In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

“…However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. …”
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Maxwell-type models for the effective thermal conductivity of a porous material with radiative transfer in the voids by Kiradjiev, KB, Halvorsen, SA, Van Gorder, RA, Howison, SD

“…In the high-temperature regime, radiative transfer within voids strongly influences the thermal conductivity of the bulk material. …”

Behind every domain there is a shift: adapting distortion-aware vision transformers for panoramic semantic segmentation by Zhang, J, Yang, K, Shi, H, ReiB, S, Peng, K, Ma, C, Fu, H, Torr, PHS, Wang, K, Stiefelhagen, R

“…Extensive experiments are conducted, which cover indoor and outdoor scenarios, and each of them is investigated with Pin2Pan and Syn2Real regimens. Trans4PASS+ achieves state-of-the-art performances on four domain adaptive panoramic semantic segmentation benchmarks. …”

Knowledge and practice regarding medication use among elderly with chronic diseases in Felda Tembangau 2, Kemayan, Pahang by Farid, Aina Natasha Mohd

“…The elderly population, defined as those aged 60 and above, faces unique challenges in managing chronic diseases due to physiological changes, limited access to healthcare information, and barriers in understanding and adhering to medication regimens. The aim of this study was to determine the levels of knowledge and practice regarding medication use among elderly with chronic diseases in FELDA Tembangau 2, Kemayan, Pahang and to explore the correlation between these two variables. …”
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Sequential phreatomagmatic eruptions during the lateral propagation of giant dyke swarms by Pryce, E, Cartwright, J, Kirkham, C, Phillips, D

“…Craters are flanked by a tephra apron comprising reworked chalky sediments. The well data allow us to exclude crater forming mechanisms based on collapse into a void, but are consistent with those linked to phreatomagmatic eruption. …”

Myanmar in Eu-Asean relations by Magnus Petersson

“…A rather skeptical view is emphasized on the ‘ASEAN Way’ in dealing with the military regime, and for the overall political dialogue with the European Union.…”
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Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
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Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Better understanding of the cellular pathways underlying this escape from antimitotic drug-induced cell death, known as mitotic slippage, is crucial for development of combinatorial therapies that can enhance existing treatment regimen in patients. Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
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Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

Topological effects on the magnetoconductivity in topological insulators by Sacksteder, Vincent E., Arnardottir, Kristin Bjorg, Kettemann, Stefan, Shelykh, Ivan A.

“…In this wrapped regime the magnetoconductivity's dependence on temperature, typically 1/T2 in 2-DEGs, disappears. …”
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Stress evolution of GaN/AlN heterostructure grown on 6H-SiC substrate by plasma assisted molecular beam epitaxy by Agrawal, Manvi, Ravikiran, Lingaparthi, Dharmarasu, Nethaji, Radhakrishnan, K., Karthikeyan, Giri Sadasivam, Zheng, Yuanjin

“…GaN/AlN structure is found to form buried cracks when AlN is grown in the intermediate growth regime(III/V∼1)and GaN is grown under N-rich growth regime (III/V<1). …”
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Assessment of novel pre-erythrocytic malaria vaccines in humans by Venkatraman, N

“…This trial showed that this regime was safe, well tolerated and did not result in any immunological interference. …”

The prevention and management of chronic kidney disease among patients with metabolic syndrome by Zhu, D, Judge, PK, Wanner, C, Haynes, R, Herrington, WG

“…In addition, statin-based regimens lower low-density lipoprotein cholesterol and reduce the risk of atherosclerotic disease (with no clinically meaningful effect on kidney outcomes). …”